A5034092432- Colorectal Cancer Surgical Treatments
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Surgical Simulation and Training
- Air Quality and Health Impacts
- Enhanced Recovery After Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Cytomegalovirus and herpesvirus research
- Anatomy and Medical Technology
- Endoplasmic Reticulum Stress and Disease
- Pediatric health and respiratory diseases
- Colorectal Cancer Screening and Detection
- Anorectal Disease Treatments and Outcomes
- Colorectal and Anal Carcinomas
- Gastrointestinal Tumor Research and Treatment
- Caveolin-1 and cellular processes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Epigenetics and DNA Methylation
- Plant Toxicity and Pharmacological Properties
- PARP inhibition in cancer therapy
- Cancer therapeutics and mechanisms
- Signaling Pathways in Disease
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
Capital Medical University
2025
Second Affiliated Hospital of Dalian Medical University
2021-2024
Dalian Medical University
2021-2024
Anhui Medical University
2013
Abstract The prevalence of non-obese nonalcoholic fatty liver disease (NAFLD) is increasing worldwide with unclear etiology and pathogenesis. Here, we show GP73, a Golgi protein upregulated in livers from patients variety diseases, exhibits Rab GTPase-activating (GAP) activity regulating ApoB export. Upon regular-diet feeding, liver-GP73-high mice display NAFLD phenotype, characterized by reduced body weight, intrahepatic lipid accumulation, gradual insulin resistance development, none which...
Laparoscopic total mesorectal excision (L-TME) is difficult to perform because of its technical shortcomings in cases anatomical condition. In such situations, robotic TME (R-TME) tends be the procedure choice. This study aimed compare R-TME and L-TME treatments for mid-low rectal cancer patients with conditions.This retrospective single-center examined data from 01/2019 02/2021 conditions. Perioperative data, short-term outcomes, 2-year oncologic outcomes were compared between groups.The...
Abstract Background Prolonged postoperative ileus (PPOI) is a common complication after colorectal surgery that increases patient discomfort, hospital stay, and financial burden. However, predictive tools to assess the risk of PPOI in patients undergoing laparoscopic low anterior resection have not been developed. Thus, purpose this study was develop nomogram predict for rectal cancer. Methods A total 548 consecutive who underwent midlow cancer at single tertiary medical center were...
Abstract Background As a phosphorylated protein, NOLC1 is mainly located in the nucleus and highly expressed variety of tumors, participating regulation cell proliferation aging. This study further investigated role colorectal cancer aiming to provide sufficient scientific evidence for clinical treatment cancer. Methods We used TCGA, GEO, TNMplot, GEPIA, other databases explore expression level patients, as well correlation between characteristics patients their expression, conducted...
The aim of the study was to compare outcomes robot-assisted (RAGD2) and laparoscopy-assisted gastrectomy with D2 lymphadenectomy (LAGD2) for patients gastric cancer.Relevant articles published up September 2020 were searched. weighted mean difference (WMD) used pool continuous variables, while risk ratio (RR) calculated dichotomous outcomes.RAGD2 required a longer operating time (WMD = 29.78, 95% confidence interval (CI): 15.97-43.59) had less operative blood loss -31.93, CI: -44.03 -19.83),...
Golgi protein 73 (GP73), also called membrane 1 (GOLM1), is a resident type II transmembrane and considered as serum marker for the detection of variety cancers. A recent work revealed role secreted GP73 in stimulating liver glucose production systemic homeostasis. Since exaggerated hepatic plays key pathogenesis diabetes mellitus (T1DM) 2 (T2DM), may thus represent potential therapeutic target treating diabetic patients with pathologically elevated levels. Here, this study, we found that...
Abstract Purpose The study aimed to analyze the clinical efficacy and safety of hand-sewn anastomosis for digestive tract with Da Vinci robot in rectal cancer surgery. Methods A retrospective was conducted collect data from 27 patients who underwent robotic radical surgery department gastrointestinal at Second Affiliated Hospital Dalian Medical University August 2019 February 2022. All received a manual suture reconstruction. After posterior wall sutured, anterior sutured continuously....
Abstract Liver metastasis is a common cause of death in colorectal cancer (CRC) patients, but epigenetic remodeling and metabolic reprogramming for CRC liver remain unclear. The study revealed that the Lyn/RUVBL1 complex highly expressed closely correlated with metastasis. On one hand, ATAC‐seq HiCut suggested regulates expression TRIB3 through POL II‐mediated chromatin conformation thus β‐catenin. This promotes proliferation migration β‐catenin‐mediated upregulation MMP9 VEGF. other...
BACKGROUND The aim of this study was to investigate the involvement CMV infection in wheezing infants and association between CMV-DNA immunoglobulins (Igs). MATERIAL AND METHODS A total 243 3,000 parturients were enrolled study. randomly grouped receive blood HCMV-DNA tests (n=46) or urine (n=197). Furthermore, all participants had serum CMV-specific IgM IgG testing. Afterwards, 10 HCMV-IgG positive selected for simultaneous tests, 25 puerperants tests. RESULTS detection rate significantly...
Summary Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces new-onset diabetes and severe metabolic complications of pre-existing diabetes. The pathogenic mechanism underlying this is incompletely understood. Here, we provided evidence linking circulating GP73 with the exaggerated gluconeogenesis triggered by SARS-CoV-2 infection. We found that or glucotoxic condition increased cellular secretion GP73. Secreted trafficked to liver kidney stimulate through cAMP/PKA...
Objective To look for a reliable and convenient judgement criteria the screening of cytomegalovirus pneumonia in order to reduce misdiagnosis resulted mistherapy.Methods Process collected data on fifty-six forty-two common viruses induced asthmatic bronchitis cases by use discriminant analysis construct prediction model diagnosis result.Results Only three indexes including age,lymph count platelet were selected into via sift.The performance established showed as follows:sensitivity was...
Objective To summarize the clinical features and provide a clue for diagnosis of CMVP cases through analyzing epidemiologic feature laboratory test results.Methods 53 were collected by department pediatrics PLA 101 hospital from September 2010 to March 2012.The CMV-IgM、CMV-IgG、CMV-DNA specimens wcrc dctcctcd.Dcscriptive cpidcmiology was used analyze their feature.Correlation analysis relation between age onset pathogenesis.Results 92.4％ under 12 months.There is negative correlation...
Abstract Purpose The study aimed to analyze the clinical efficacy and safety of hand-sewn anastomosis for digestive tract with Da Vinci robot in rectal cancer surgery. Materials methods A retrospective was conducted collect data from 27 patients who underwent robotic radical surgery department gastrointestinal at Second Affiliated Hospital Dalian Medical University August 2019 February 2022. All received a manual suture reconstruction. After posterior wall sutured, anterior sutured...
Abstract Purpose Analysis of the clinical value postoperative circulating tumor DNA (ctDNA) within first month for resected colorectal cancer in a real-world. Methods In this longitudinal cohort study, 42 resectable CRC patients with stage I-III were enrolled and treated per standard care. Tumor tissues (n = 42) serial plasma samples 161) collected detected massively parallel sequencing to evaluate somatic variants. Recurrence monitoring during approximately 2 years follow-up period was...
Abstract Background The latest statistics indicate a gradual increase in the incidence of rectal cancer, with approximately 60–70% patients being diagnosed at an advanced stage. Presently, robot-assisted surgery is extensively performed numerous countries worldwide. To evaluate short-term efficacy and long-term outcomes Da Vinci robot middle low cancer. Methods A case series analysis was conducted on 235 cancer who were admitted to First Department Gastrointestinal Surgery, Second Affiliated...
Abstract Background : Prolonged postoperative ileus (PPOI) is a common complication after colorectal surgery that increases patient discomfort, hospital stay, and financial burden. However, predictive tools to assess the risk of PPOI in patients undergoing laparoscopic low anterior resection have not been developed. Thus, purpose this study was develop nomogram predict for rectal cancer. Methods A total 548 consecutive who underwent midlow cancer at single tertiary medical center were...
Objective The study examined the levels of exhaled nitric oxide (eNO) and maximum peak flow (PEF) as well correlation between both in children year 6 16 with bronchial asthma (asthma) chronic cough variant (CVA).Furthermore,the research diagnosis remedy value CVA.Methods eNO level was measured electrochemical photometry 23 cases diagnosed asthma,29 CVA 37 without atopic disease acute respiratory infection family history served control group.Results groups were significant higher than those...
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces new-onset diabetes and severe metabolic complications of pre-existing diabetes. The pathogenic mechanism underlying this is incompletely understood. Here, we provided evidence linking circulating GP73 with the exaggerated gluconeogenesis triggered by SARS-CoV-2 infection. We found that or glucotoxic conditions increased production secretion. Secreted then trafficked to liver kidney stimulate through...