A5100395167- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV Research and Treatment
- Cardiac Structural Anomalies and Repair
- HIV/AIDS drug development and treatment
- Cardiac Valve Diseases and Treatments
- HIV/AIDS Research and Interventions
- Long-Term Effects of COVID-19
- Antimicrobial Resistance in Staphylococcus
- Herpesvirus Infections and Treatments
- Bacillus and Francisella bacterial research
- Animal Virus Infections Studies
- Antifungal resistance and susceptibility
- Gut microbiota and health
- Bacterial biofilms and quorum sensing
- vaccines and immunoinformatics approaches
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral Infections and Vectors
- Monoclonal and Polyclonal Antibodies Research
- Adrenal Hormones and Disorders
- Virus-based gene therapy research
- Aortic Disease and Treatment Approaches
- Infectious Diseases and Tuberculosis
- Clostridium difficile and Clostridium perfringens research
- Acute Myocardial Infarction Research
National Institute of Allergy and Infectious Diseases
2019-2024
National Institutes of Health
2019-2024
Northwestern University
2024
Northern Jiangsu People's Hospital
2024
Qingdao University
2023
Wuhan Institute of Virology
2023
Affiliated Hospital of Qingdao University
2023
Institute of Microbiology
2013-2022
Aerospace Center Hospital
2022
Beijing VDJBio (China)
2021
Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects clinical treatments in SARS patients lacking. Here total 25 recovered were recruited 12 years after infection. Clinical questionnaire responses examination findings indicated that had experienced various diseases, including lung susceptibility infections, tumors, cardiovascular disorders, abnormal glucose metabolism. As compared...
Abstract In this study, we specifically addressed the connection between SARS-CoV-2 virus with host cholesterol metabolism. Plasma lipid profile was measured in 861 COVID-19 patients classified as mild (n=215), moderate (n=364), severe (n=217) or critical (n=65) and 1108 age- sex-matched healthy individuals. We showed that levels of both TG HDL-C were significantly lower disease than disease. After successful treatment, metabolism reestablished infection. The serum concentrations TC can be...
Background. Interferon is a marker of host antiviral immunity, which disordered in COVID-19 patients. ERV can affect the secretion interferon through cGAS-STING pathway. In this study, we explored whether IFN-I and HERV-K (HML-2) were activated patients there was an interaction between them. Methods. We collected blood samples from healthy controls. first detected expression gag, env, pol genes IFN-I-related people by qPCR, synchronously VERO cells infected with SARS-CoV-2. Then, chromosome...
Objectives Our objective was to determine the antibody and cytokine profiles in different COVID-19 patients. Methods patients with clinical classifications were enrolled this study. The level of IgG antibodies, IgA, IgM, IgE, subclasses targeting N S proteins tested using ELISA. Neutralizing titers determined by a toxin neutralization assay (TNA) live SARS-CoV-2. concentrations 8 cytokines, including IL-2, IL-4, IL-6, IL-10, CCL2, CXCL10, IFN-γ, TNF-α, measured Protein Sample Ella-Simple...
Background Assessing the prevalence of HIV-1 drug-resistance and mutation patterns associated with resistance in geographical regions implementing free antiretroviral therapy (ART) China is necessary for preventing spread resistant strains designing regimens subsequent therapies limited resources. Methods Plasma samples different cities/prefectures were collected at Yunnan Provincial Hospital Infectious Disease from January 2010 to December 2011. Genotyping drug-resistant individuals was...
Considering the current situation of novel coronavirus disease (COVID-19) epidemic control, it is highly likely that COVID-19 and influenza may coincide during approaching winter season. However, there no available tool can rapidly precisely distinguish between these two diseases in absence laboratory evidence specific pathogens.Laboratory-confirmed patients December 1, 2019 February 29, 2020, from Zhongnan Hospital Wuhan University (ZHWU) No.1 (WNH) located Wuhan, China, were included for...
Abstract Synthetic glucocorticoid dexamethasone is the first trial-proven drug that reduces COVID-19 mortality by suppressing immune system. In contrast, interferons are a crucial component of host antiviral immunity and can be directly suppressed glucocorticoids. To investigate whether therapeutic compensate glucocorticoids-induced loss immunity, we retrospectively analyzed cohort 387 PCR-confirmed patients with quasi-random exposure to conditional Among receiving glucocorticoids, early...
Non-sputum-based tests to accurately identify active tuberculosis (TB) disease and monitor response therapy are urgently needed. This study examined the biomarker capacity of a panel plasma proteins alone, in conjunction with previously identified miRNA signature, TB disease.The expression nine (IP-10, MCP-1, sTNFR1, RANTES, VEGF, IL-6, IL-10, TNF Eotaxin) was measured 100 control subjects patients, at diagnosis (treatment naïve) over course treatment (1-, 2- 6-month intervals). The...
Abstract Objectives The ‘treat-all’ strategy was implemented in Shenzhen, China 2016. effect of this extensive treatment on transmitted drug resistance (TDR) HIV is unclear. Methods TDR analysis performed, based the partial HIV-1 pol gene obtained from newly reported positive cases 2011 to 2019 China. molecular transmission networks were inferred analyse spread TDR. Logistic regression used identify potential risk factors with mutations (TDRMs) cluster. Results A total 12 320 sequences...
Our objective was to evaluate the long-term prognostic value of high-sensitivity cardiac troponin-I (hs-cTn-I) in idiopathic dilated cardiomyopathy (DCM). First, patients were divided into an end-event group (n = 55) and a non-end-event 67). Then, included subgroup analysis compare diagnostic brain natriuretic peptide (BNP) hs-cTn-I different populations. BNP concentrations higher group. The Cox regression indicated that high risk factor for poor prognosis. Receiver operating characteristic...
Objective Intraoperative surgical repair of acute type A aortic dissection, sometimes we would encounter special cases that failed to wean from CPB. In this study, aimed retrospectively analyze the indication, clinical experience and short midterm outcomes dissection concomitant CABG or ECMO support in patients who Methods total 532 consecutive underwent emergent surgery for TAAD a single institution between Jan 2018 2023. And categorized into group based on approach. Preoperative,...
Abstract Sulfobutyl ether‐beta‐cyclodextrin sodium salt contained in the marketed intravenous voriconazole injection as a solubilizer may cause harmful accumulations. This study aimed to evaluate safety, tolerability, and pharmacokinetics (PKs) of two formulations containing excipients from different manufacturers using increasing dose administrations healthy Chinese volunteers. A randomized, double‐blind, placebo‐controlled trial was conducted three cohorts with 42 Each cohort 14 volunteers...