A5016688779- Sensor Technology and Measurement Systems
- RNA Interference and Gene Delivery
- Virus-based gene therapy research
- Pneumonia and Respiratory Infections
- SARS-CoV-2 and COVID-19 Research
- Advanced Computational Techniques and Applications
- Engineering and Test Systems
- Bacterial Infections and Vaccines
- Influenza Virus Research Studies
- Advanced biosensing and bioanalysis techniques
- Advanced Database Systems and Queries
- Advanced Sensor Technologies Research
- Respiratory viral infections research
- Fault Detection and Control Systems
- Embedded Systems Design Techniques
- Algorithms and Data Compression
- Plasma Diagnostics and Applications
- Semantic Web and Ontologies
- Wireless Communication Networks Research
- Power Line Communications and Noise
- CRISPR and Genetic Engineering
- Vaccine Coverage and Hesitancy
- Laser-induced spectroscopy and plasma
- Service-Oriented Architecture and Web Services
- COVID-19 epidemiological studies
Pfizer (United States)
2023-2025
The University of Adelaide
2021
Abcombi Biosciences (United States)
2015-2020
Health Economics and Outcomes Research (United Kingdom)
2019
University at Buffalo, State University of New York
2013-2016
Buffalo State University
2014
United States Air Force Research Laboratory
2007-2008
Edwards Air Force Base
1990-2006
59th Medical Wing
2005
U.S. Air Force Test Center
2005
A key end goal of gene delivery research is to develop clinically relevant vectors that can be used combat elusive diseases such as AIDS. Despite promising engineering strategies, efficiency and ultimately modulation efficacy nonviral have been hindered by numerous in vitro vivo barriers resulted subviral performance. In this perspective, we concentrate on the associated with two most common classes vectors, cationic-based lipids polymers. We present existing summarize current...
Abstract The US healthcare system is at a crossroads. With an aging population requiring more care and strained facing workforce shortages, capacity issues, fragmentation, innovative solutions policy reforms are needed. This paper aims to spark dialogue collaboration among stakeholders inspire action meet the needs of population. Through comprehensive analysis impact society, this work highlights urgency addressing issue importance restructuring be efficient, equitable, responsive.
Abstract In the past decade, RNA therapeutics have gone from being a promising concept to one of most exciting frontiers in healthcare and pharmaceuticals. The field is now entering what many call renaissance or “RNAissance” which fueled by advances genetic engineering delivery systems take on more ambitious development efforts. However, this occurring at an unprecedented pace, will require different way thinking if live up its full potential. Recognizing need, article provide...
Well-defined cationic polylactides (CPLAs) with tertiary amine groups were synthesized by thiol-ene click functionalization of an allyl-functionalized polylactide to yield polymers tunable charge densities. CPLAs have not previously been utilized in the context DNA delivery. Thus, plasmid (pDNA) encoding luciferase was delivered two physiologically distinct cell lines (macrophage and fibroblast) via formation CPLA/pDNA polyplexes electrostatic interaction. The formulated demonstrated high...
Well-defined chitosan nanocapsules (CSNCs) with tunable sizes were synthesized through the interfacial cross-linking of N-maleoyl-functionalized (MCS) in miniemulsions, and their application delivery doxorubicin (Dox) was investigated. MCS prepared by amidation reaction CS maleic anhydride water/DMSO at 65 °C for 20 h. Subsequently, thiol–ene conducted oil-in-water miniemulsions room temperature under UV irradiation 1 h, using as both a surfactant precursor polymer, 1,4-butanediol...
Abstract Amidst the backdrop of COVID-19 pandemic, vaccine innovation has garnered significant attention, but this field was already on cusp a groundbreaking renaissance. Propelling these advancements are scientific and technological breakthroughs, alongside growing understanding societal economic boons vaccines offer, particularly for non-pediatric populations like adults immunocompromised. In departure from previous decades where launches could be seamlessly integrated into existing...
Immunization strategies against commensal bacterial pathogens have long focused on eradicating asymptomatic carriage as well disease, resulting in changes the colonizing microflora with unknown future consequences. Additionally, current vaccines are not easily adaptable to sequence diversity and immune evasion. Here, we present a "smart" vaccine that leverages our understanding of disease transition from infection pneumococcus serving model organism. Using conserved surface proteins highly...
ABSTRACT Yersiniabactin (Ybt) is a mixed nonribosomal peptide-polyketide natural product natively produced by the pathogen Yersinia pestis . The compound enables iron scavenging capabilities upon host infection and biosynthesized peptide synthetase featuring polyketide synthase module. This pathway has been engineered for expression biosynthesis using Escherichia coli as heterologous host. In current work, biosynthetic process Ybt formation was improved through incorporation of dedicated...
Genetic vaccination is predicated on the underlying principle that diseases can be prevented by controlled introduction of genetic material encoding antigenic proteins from pathogenic organisms to elicit formation protective immune responses. Driving this process choice carrier responsible for navigating obstacles associated with gene delivery. In work, we expand upon a novel class hybrid biosynthetic delivery vectors are composed biomaterial outer coating and bacterial (Escherichia coli)...
A comprehensive design offers global pneumococcal vaccine coverage.
Abstract In chronic obstructive pulmonary disease (COPD) apoptotic bronchial epithelial cells are increased, and their phagocytosis by alveolar macrophages (AM) is decreased alongside bacterial phagocytosis. Epithelial cellular lipids, including those exposed on uncleared bodies, can become oxidized, may be recognized presented as non-self antigen presenting cells. CD1b a lipid-presenting protein, previously only described in dendritic We investigated whether upregulated COPD AM, lipid...
In an increasingly interconnected world, the threat of a devastating influenza pandemic looms large. Highly pathogenic avian A(H5N1), with its high case fatality rate and potential for adaptation in reservoirs, is prime candidate triggering such pandemic. We applied Viral Trait Assessment Pandemics (ViTAP) model, quantitative framework, to assess H5N1 strains currently circulating United States. Through systematic literature review structured expert elicitation involving virologists...
We modeled the impact of initiating one-dose influenza vaccination at 3 months vs 6 after declaration a pandemic over 1-year timeframe in US population. Three vaccine effectiveness (VE) and two severity levels were considered, using an epidemic curve based on typical seasonal epidemics. Vaccination from with high, moderate, or low would prevent ~95%, 84%, 38% deaths post-vaccination, respectively, compared 21%, 18%, 8%, respectively following months, irrespective severity. While not be...