A5058029445- Pain Mechanisms and Treatments
- Wnt/β-catenin signaling in development and cancer
- Botulinum Toxin and Related Neurological Disorders
- HIV Research and Treatment
- Cytomegalovirus and herpesvirus research
- Nerve injury and regeneration
- HIV/AIDS drug development and treatment
- Connexins and lens biology
- Cancer-related Molecular Pathways
- Genetics and Neurodevelopmental Disorders
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Fibroblast Growth Factor Research
- Herpesvirus Infections and Treatments
- Immune Response and Inflammation
- Viral Infections and Immunology Research
- CRISPR and Genetic Engineering
- Cancer-related gene regulation
- Neuroscience of respiration and sleep
- Advanced biosensing and bioanalysis techniques
- Endoplasmic Reticulum Stress and Disease
- Peripheral Neuropathies and Disorders
- Anesthesia and Neurotoxicity Research
- SARS-CoV-2 detection and testing
- Functional Brain Connectivity Studies
Yonsei University
2025
Yale University
2024
University of Miami
2012-2024
Sichuan University
2024
Janelia Research Campus
2021
Howard Hughes Medical Institute
2021
Helix (United States)
2021
University at Buffalo, State University of New York
2011-2019
Chungbuk National University
2003-2013
Duke Medical Center
2009
Brain-derived neurotrophic factor (BDNF) is a well characterized neurotrophin that mediates wide variety of activities in the central nervous system, including neuronal differentiation, neuroprotection, and synaptic plasticity. The canonical Wnt signaling pathway critical regulator embryonic development homeostasis adult tissues. Our group others recently demonstrated induces BDNF expression neurons glia. However, precise relationship between pathways not understood. Here, we investigated...
Abstract Background The Wnt signaling pathway is a cellular communication that plays critical roles in development and disease. A major class of regulators the Dickkopf (Dkk) family secreted glycoproteins. Although biological properties 1 (Dkk1) 2 (Dkk2) are well characterized, little known about function related 3 (Dkk3) protein vivo or cell lines. We recently demonstrated Dkk3 transcripts upregulated during photoreceptor death mouse model retinal degeneration. In this study, we...
Wnt/β-catenin signaling is an essential pathway that regulates numerous cellular processes, including cell survival. The molecular mechanisms contributing to pro-survival Wnt are mostly unknown. Signal transducer and activator of transcription proteins (STATs) a well-described family factors. STAT3 induces expression anti-apoptotic genes in many tissues downstream mediator protective growth factors cytokines. In this study, we investigated whether mediated by STAT3. Wnt3a ligand activated...
Recent evidence has implicated innate immunity in regulating neuronal survival the brain during stroke and other neurodegenerations. Photoreceptors are specialized light-detecting neurons retina that essential for vision. In this study, we investigated role of receptor TLR4 photoreceptors. activation by lipopolysaccharide (LPS) significantly reduced cultured mouse photoreceptors exposed to oxidative stress. With respect mechanism, suppressed Wnt signaling, decreased phosphorylation LRP6,...
Mitochondria play an important role in many cellular and physiologic functions. are dynamic organelles, their fusion fission regulate signaling, development, mitochondrial homeostasis. The most common complaint of human immunodeficiency virus (HIV)-sensory neuropathy is pain on the soles patients with HIV, but exact molecular mechanisms HIV neuropathic not clear. In present study, we investigated dynamin-related protein 1 (Drp1, a GTPase that mediates fission) perineural coat glycoprotein...
The Wnt pathway is an essential signaling cascade that regulates multiple processes in developing and adult tissues, including differentiation, cellular survival, stem cell proliferation. authors recently demonstrated altered expression of genes during photoreceptor death rd1 mice, suggesting involvement for the disease process. In this study, investigated role retinal degeneration.The reporter mouse line Tcf-LacZ was crossed with degeneration beta-galactosidase used to localize death. To...
The worldwide coronavirus disease 2019 pandemic has had devastating effects on health, healthcare infrastructure, social structure, and economics. One of the limiting factors in containing spread this virus been lack widespread availability fast, inexpensive, reliable methods for testing individuals. Frequent screening infected often asymptomatic people is a cornerstone management plans. Here, we introduce 2 pH-sensitive "LAMPshade" dyes as novel readouts an isothermal Reverse Transcriptase...
Abstract Hemophilia A (HA) is caused by mutations in coagulation factor VIII ( FVIII ). Genome editing conjunction with patient-derived induced pluripotent stem cells (iPSCs) a promising cell therapy strategy, as it replaces dysfunctional proteins resulting from genetic normal proteins. However, the low expression level and short half-life of still remain significant limiting factors efficacy these approaches HA. Here, we constructed functionally enhanced variant, F309S/E1984V-mutated B...
Visual hallucinations have haunted humanity for millennia. While our explanations these phenomena are now more soundly based in neuroscience, understanding of their provenance remains superficial. In particular, the role specific visual system disruptions generation unclear. We and others recently demonstrated that psychosis-spectrum illness can be engendered by over-weighting expectations during perception. Emerging evidence suggests this state affairs is also true other neuropsychiatric...
Emerging evidence suggests that hallucinations may arise because of an over-reliance on prior knowledge during perception. While best established in psychosis-spectrum illness, data also support the presence this abnormality other neuropsychiatric illnesses vary their association with disruption visual sensory circuits. In piece, we ask whether over-weighting expectations be conceived as a compensatory response to incoming noise. We make case hallucinogenesis across wide array disorders can...
Human immunodeficiency virus (HIV)-related painful sensory neuropathies primarily consist of the HIV infection-related distal polyneuropathy and antiretroviral toxic neuropathies. Pharmacotherapy provides only partial relief pain in patients with HIV/acquired immune deficiency syndrome because little is known about exact neuropathological mechanisms for HIV-associated neuropathic (NP). Hypofunction γ-aminobutyric acid (GABA) GABAergic inhibitory has been reported after peripheral nerve...
BACKGROUND: Chronic pain is one of the most common complaints in patients with human immunodeficiency virus (HIV)–associated sensory neuropathy. Ryanodine receptor (RyR) and mitochondrial oxidative stress are involved neuropathic induced by nerve injury. Here, we investigated role RyR superoxide repeated intrathecal HIV glycoprotein 120 (gp120) injection. METHODS: Recombinant gp120MN was intrathecally administered to induce pain. Mechanical threshold tested using von Frey filaments....
In the human immunodeficiency virus (HIV)-associated sensory neuropathy, neuropathic pain associated with use of nucleoside reverse transcriptase inhibitors (NRTIs) in patients HIV/acquired syndrome is clinically common. While evidence demonstrates that influenced by neuroinflammatory events include proinflammatory molecules, tumor necrosis factor-α (TNF-α), stromal cell-derived factor 1-α (SDF1-α), and C-X-C chemokine receptor type 4 (CXCR4), detailed mechanisms which NRTIs contribute to...
The symptoms of HIV-sensory neuropathy are dominated by neuropathic pain. Recent data show that repeated use opiates enhances the chronic pain states in HIV patients. Limited attention has so far been devoted to exploring exact pathogenesis painful disorder and opiate abuse vivo, for which there is no effective treatment. Bromodomain-containing protein 4 (Brd4) a member bromodomain extraterminal domain (BET) family functions as chromatin 'reader' binds acetylated lysines histones brain...
The most recent Ebola virus disease outbreak, from 2014 to 2016, resulted in approximately 28,000 individuals becoming infected, which led over 12,000 causalities worldwide. particularly high pathogenicity of the makes paramount identification and development promising lead compounds serve as inhibitors infection. To limit viral load, virus-host membrane fusion event can be targeted through inhibition class I glycoprotein Ebolavirus . In current work, several small-molecule that target GP2...