A5075542618- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Cardiovascular Health and Risk Factors
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Venous Thromboembolism Diagnosis and Management
- Healthcare Systems and Public Health
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Urban Green Space and Health
- BRCA gene mutations in cancer
- Genetic factors in colorectal cancer
- Genetic Associations and Epidemiology
- COVID-19 and healthcare impacts
- Cervical Cancer and HPV Research
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disease Mechanisms and Treatments
- Health disparities and outcomes
- Neurological Disorders and Treatments
- Alcohol Consumption and Health Effects
- Peripheral Artery Disease Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Multiple and Secondary Primary Cancers
University of Miami
2016-2025
Southern University of Science and Technology
2025
Zhejiang Chinese Medical University
2025
China Medical University
2024
Henan Provincial People's Hospital
2024
American Heart Association
2016-2023
University of South Florida
2016-2023
Baptist Health South Florida
2023
Florida International University
2017-2023
University of Puerto Rico System
2016-2018
Background— Evidence of the relationship cardiovascular health (CVH), defined by American Heart Association, and specific outcomes is lacking, particularly among Hispanics. This study sought to evaluate between number ideal CVH metrics risk, overall event subtype, in a multiethnic community-based prospective cohort. Methods Results— A total 2981 subjects (mean age, 69±10 years; 54% Caribbean Hispanic, 25% black, 21% white) free myocardial infarction stroke at baseline Northern Manhattan...
Overexpression of soluble urokinase receptor (suPAR) causes pathology in animal models similar to primary FSGS, and one recent study demonstrated elevated levels serum suPAR patients with the disease. Here, we analyzed circulating two cohorts children adults biopsy-proven FSGS: 70 from North America–based FSGS clinical trial (CT) 94 PodoNet, Europe-based consortium studying steroid-resistant nephrotic syndrome. Circulating were 84.3% 55.3% CT PodoNet cohorts, respectively, compared 6%...
We studied seven genes that reflect events relevant to antidepressant action at four sequential levels: (1) entry into the brain, (2) binding monoaminergic transporters, and (3) distal effects transcription level, resulting in (4) changes neurotrophin neuropeptide receptors. Those are ATP-binding cassette subfamily B member 1 (ABCB1), noradrenaline, dopamine, serotonin transporters (SLC6A2, SLC6A3 SLC6A4), cyclic AMP-responsive element protein (CREB1), corticotropin-releasing hormone...
Making a limb transiently ischemic has been shown to induce tolerance in distant organ. This phenomenon is known as remote preconditioning. We conducted Phase IB study of preconditioning determine the safety and feasibility increasing durations ischemia patients with subarachnoid hemorrhage.Patients aneurysmal hemorrhage underwent every 24 48 hours for 14 days. Limb consisted 3 5-minute inflations blood pressure cuff 200 mm Hg around followed by 5 minutes reperfusion. In lead-in phase, we...
Background The majority of Americans consume alcoholic beverages. Alcohol interacts negatively with numerous commonly prescribed medications. Yet, on a population level, little is known about use alcohol‐interactive ( AI ) prescription medications among drinkers. purpose our study was to determine the prevalence medication current drinkers in U.S. population. Methods Data were from National Health and Nutrition Examination Survey NHANES 1999 2010); 26,657 adults aged ≥20 years had data past...
Prior studies suggest that exposure to the natural environment may be important for optimal mental health. The present study examines association between block-level greenness (vegetative presence) and health outcomes, in a population-based sample of 249,405 U.S. Medicare beneficiaries aged ≥65 years living Miami-Dade County, Florida, USA, whose location did not change from 2010 2011. Multilevel analyses examined relationships greenness, as measured by mean Normalized Difference Vegetation...
Intra-arterial (IA) delivery of mesenchymal stem cells (MSCs) for acute ischemic stroke is attractive clinical translation. However, studies using rat model have demonstrated that IA MSCs can decrease middle cerebral artery (MCA) flow, which may limit its The goal this study to identify a dose (maximum tolerated dose; MTD) does not compromise MCA flow and evaluate efficacy optimal timing in reversible occlusion (rMCAo). We sought determine if there difference (1 h) versus sub-acute (24...
Background Nature exposures may be associated with reduced risk of heart disease. The present study examines the relationship between objective measures neighborhood greenness (vegetative presence) and 4 disease diagnoses (acute myocardial infarction, ischemic disease, failure, atrial fibrillation) in a population-based sample Medicare beneficiaries. Methods Results included 249 405 beneficiaries aged 65 years older whose location ( ZIP +4) Miami-Dade County, Florida, did not change from...
The Swedish Family-Cancer Database was used to analyze concordant (same site) and discordant (different second primary neoplasms in 633,964 cancer patients diagnosed from 1958 1996. Cases of malignant were extracted the if diagnosis date first differed by at least 1 month. expected numbers cancers obtained applying site-, sex-, age-, period-, residence- socioeconomic level-specific rates corresponding population appropriate person-years risk. standardized incidence ratio (SIRs) a taken be...
The study aimed at probing the possible role of human papillomavirus (HPV) infection in squamous cell carcinomas upper aerodigestive tract, with a special reference to tonsillar cancer. We used Swedish Family Cancer Database analyse second cancers tract women first diagnosed in-situ or invasive cervical First their husbands were also analysed. Standardized incidence ratios (SIRs) calculated for female and male cancers, adjusted age diagnosis, period, sex, socio-economic status residential...
Subclinical atherosclerotic plaque is an important marker of increased vascular risk. Identifying factors underlying the variability in burden carotid unexplained by traditional risk may help target novel preventive strategies.As a part substudy Northern Manhattan Study (NOMAS), 1790 stroke-free individuals (mean age, 69±9; 60% women; 61% Hispanic, 19% black, 18% white) were assessed for total area (TPA) using 2-dimensional ultrasound imaging. Multiple linear regression models constructed....
Background and Purpose— Carotid intima-media thickness (cIMT) was a widely accepted ultrasound marker of subclinical atherosclerosis in the past. Although traditional risk factors may explain ≈50% variance plaque burden, they not such high proportion IMT, especially when measured plaque-freel ocations. We aimed this study to identify individuals with cIMT unexplained by for future environmental genetic research. Methods— As part Northern Manhattan Study, 1790 stroke-free (mean age, 69±9...
Major depressive disorder (MDD) is the most common psychiatric and second overall cause of disability. Even though a significant amount variance in MDD phenotype explained by inheritance, specific genetic variants conferring susceptibility to explain only minimal proportion causality. Moreover, genome-wide association studies have identified two small-sized effect loci that reach significance. In this study, group Mexican-American patients with controls recruited for pharmacogenetic study...
Background The American Heart Association defined target levels for 7 cardiovascular health ( CVH ) factors: smoking, body mass index, physical activity, diet, blood pressure, cholesterol, and glucose. We hypothesized that a greater number of ideal metrics would be associated with less decline in cognitive performance our multiethnic population. Methods Results A subsample from the population‐based Northern Manhattan Study underwent repeated neuropsychological testing (mean interval 6±2...
Background and Purpose— Sex-specific disparities in stroke care including thrombolytic therapy early hospital admission are reported. In a large registry of Florida Puerto Rico hospitals participating the Get With The Guidelines—Stroke program, we sought to determine sex-specific differences ischemic performance metrics overall treatment. Methods— Around 51 317 (49% women) patients were included from 73 sites 2010 2014. Multivariable logistic regression with generalized estimating equations...
Migraine with aura is a risk factor for ischemic stroke. The goals of this study are to examine the association between migraine and subclinical cerebrovascular damage in race/ethnically diverse older population-based cohort study.In Northern Manhattan Study (NOMAS), we quantified brain infarctions white matter hyperintensity volumes among participants self-reported migraine, confirmed by International Classification Headache Disorders-2 criteria.Of 546 imaging data (41% men; mean age at...
The Swedish Family-Cancer Database was used to analyze familial relationships in mothers and daughters invasive situ cervical cancers from years 1958–1994, including a total of 125,000 14,000 cancers. In were diagnosed on average 10 earlier than Familial relative risks (FRRs) calculated separately for daughters, between 1.8 2.3 the 2 forms. only slightly modified by age onset, except at higher ages where there no risk; mothers, increased if more one daughter affected. Aggregation cases among...
<h3>Objective:</h3> To examine fibroblast growth factor 23 (FGF23) as a risk for incident stroke in racially/ethnically diverse population-based urban cohort. <h3>Methods:</h3> Stroke-free Northern Manhattan Study participants with FGF23 measurements (n = 2,525) were followed mean of 12 (±5) years to detect strokes. We used Cox proportional hazards models estimate the association baseline total, ischemic, and hemorrhagic stroke. <h3>Results:</h3> Median was 57 relative units (RU)/mL...
Objective: Premised on biological evidence from animal research, recent clinical studies have, for the most part, concluded that elevated blood alcohol concentration levels are independently associated with higher survival or decreased mortality in patients moderate to severe traumatic brain injury (TBI). This study aims provide some counterevidence this claim and further future investigations. Method: Incident data were drawn largest U.S. trauma registry, National Trauma Data Bank,...
Background and Purpose— Low serum albumin concentrations have been associated with increased stroke risk, but the underlying mechanisms are less well studied. We aimed to investigate association between levels ischemic etiologies in a large, population-based, multiethnic, prospective, cohort study. Methods— Participants from Northern Manhattan Study (NOMAS; n=2986; mean age, 69±10 years) free of at baseline were followed for incident (a median follow-up 12 years). Cox proportional hazard...
Sirtuins (SIRTs) and mitochondrial uncoupling proteins (UCPs) have been implicated in cardiovascular diseases through the control of reactive oxygen species production. This study sought to investigate association between genetic variants SIRT UCP genes carotid plaque.In a group 1018 stroke-free subjects from Northern Manhattan Study with high-definition ultrasonography genotyping, we investigated associations 85 single nucleotide polymorphisms (SNPs) 11 presence number plaques, evaluated...