A5010034064- Sarcoma Diagnosis and Treatment
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Digital Imaging for Blood Diseases
- Vascular Tumors and Angiosarcomas
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Soft tissue tumor case studies
- Lung Cancer Treatments and Mutations
- Cardiac tumors and thrombi
- Urologic and reproductive health conditions
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Bone Tumor Diagnosis and Treatments
- Tuberous Sclerosis Complex Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Jinan University
2015
Sun Yat-sen Memorial Hospital
2015
Red Cross Hospital
2015
Women & Infants Hospital of Rhode Island
2014
Brown University
2014
Sun Yat-sen University Cancer Center
2010
Shandong Tumor Hospital
2009
Shandong First Medical University
2009
Abstract The poor prognosis of malignant gliomas is largely attributed to their highly invasive nature. molecular mechanism underlying the invasiveness glioma cells, however, remains be elucidated. present study found that astrocyte elevated gene-1 (AEG-1) was upregulated in human cell lines and tissues compared with normal astrocytes brain tissues. AEG-1 265 296 (89.5%) sections, expression level significantly correlated clinicopathologic stages gliomas. Ectopic or short hairpin RNA...
Pathological examination is the gold standard for diagnosis of cancer. Common pathological examinations include hematoxylin-eosin (H&E) staining and immunohistochemistry (IHC). In some cases, it hard to make accurate diagnoses cancer by referring only H&E images. Whereas, IHC can further provide enough evidence process. Hence, generation virtual images from H&E-stained will be a good solution current accessibility issue, especially low-resource regions. However, existing approaches have...
Compared with the traditional single therapy, nanomedicine has promoted a multimodal combination treatment for various carcinomas, especially development of corresponding intelligent multifunctional biomaterials based on advanced DNA nanotechnology great potential in cancer therapy. Herein, we describe strategy to "backpack" aptamer PL1, which specifically binds PD-L1 and Pcsk9 siRNA well-defined tetrahedral nanoparticles (TDNs) via hybridization, collectively contributes effective therapy...
Bone osteogenic sarcoma has a poor prognosis as the exact cell of origin and signaling pathways underling tumor formation remain undefined. Here, we report an mouse model based on conditional knockout liver kinase b1 (Lkb1; also known Stk11) in Cathepsin K (Ctsk)-Cre expressing cells. Lineage tracing studies demonstrated that Ctsk-Cre could label population periosteal The cells functioned mesenchymal progenitors with regard to markers functional properties. LKB1 deficiency increased...
The present study was aimed at investigating the expression of metastasis-associated in colon cancer 1 (MACC1) nasopharyngeal carcinoma (NPC), its relationship with β-catenin, Met and clinicopathological features NPC, roles carcinogenesis NPC. Our results showed that MACC1 higher NPC cells tissues than normal chronic inflammation nasopharynx tissues, respectively. closely related to clinical stage (p = 0.005) N classification (p<0.05) Significant correlations between 0.003), β-catenin...
This study aimed to elucidate how miR-27a-3p modulates the Wnt/β-catenin signaling pathway promote colorectal cancer (CRC) progression. Our results showed that expression of was up-regulated in CRC and closely associated with histological differentiation, clinical stage, distant metastasis patients' survival. mimic suppressed apoptosis promoted proliferation, migration, invasion cells vitro vivo. Whereas inhibitor Furthermore, RXRα target gene CRC. negatively correlated tissues. The...
// Tiantian Zhen 1,* , Sujuan Dai Hui Li Yang Lili Kang 1 Huijuan Shi Fenfen Zhang Dongjie 2 Shirong Cai Yulong He Yingjie Liang and Anjia Han Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China Gastrointestinal Surgery, * These authors contributed equally to this work Correspondence: Han, email: Keywords : MACC1, β-catenin, colorectal cancer, carcinogenesis Received February 7, 2014 Accepted May 18, Published 20, Abstract Here we confirmed...
Osteosarcoma is a primary malignant bone tumor that has high potential to metastasize lungs. Little known about the mechanisms underlying dissemination of OS cancer cells We performed whole exome sequencing 13 tumors, with matched lung metastases and normal tissues. Phylogenetic analyses revealed metastatic tumors often harbor clones are nonexistent or rare in tumors. Spatially temporally separated were from parallel seeding events polyphyletic pattern. Loss TP53 RB1 among early during...
Having reviewed the data on 3,663 consecutive cases of primary lung carcinoma in southern China, we found that 32 could meet criteria for lymphoepithelioma-like (LELC) lung. To study relationship between pulmonary LELC and Epstein-Barr virus (EBV) infection, used situ hybridization immunohistochemistry techniques to detect EBV-encoded small nonpolyadenylated RNA (EBER), latent membrane protein 1 (LMP1), viral capsid antigen (VCA) 19 non-LELC carcinoma. Of cases, 30 (94%) showed EBER...
Inflammatory pseudotumour-like follicular dendritic cell (FDC) tumour is an extremely rare neoplasm. Herein, we report 10 cases of inflammatory FDC tumours in the abdomen and analyse their clinicopathological features.Seven patients were male, three female. The patients' age ranged from 28 years to 68 (mean age, 52.9 years; median 51.5 years). Grossly, was usually solitary, well circumscribed, solid, ranging 23 mm 233 greatest diameter. Microscopically, composed variable amounts spindle...
Aims To clarify claudin18.2 expression and its clinicopathological features in various cancers, especially lung adenocarcinoma. Methods Immunohistochemistry staining fluorescence situ hybridisation (FISH) were performed to detect CLDN18 gene rearrangement adenocarcinoma from different organs. Results The results showed that was found 68% (27 of 40) mucinous adenocarcinoma, 52% (16 31) cholangiocarcinoma, 2% (10 423) colorectal tissue microarray, 27% (6 22) 30% (3 10) cervical but not all 39...
Accurate diagnosis of cerebral tumors is crucial for effective clinical therapeutics and prognosis. However, limitations in brain biopsy tissues the scarcity pathologists specializing hinder comprehensive tests precise diagnosis. To address these challenges, we first established a tumor dataset 3,520 cases collected from multiple centers. We then proposed novel Hierarchically Optimized Multiple Instance Learning (HOMIL) method classifying six common types, glioma grading, predicting origin...
Epidemiological and clinical studies suggest that an increased intake of dietary selenium significantly reduces overall cancer risk, but the anticancer mechanism is not clear. In this study, we fed intestinal mouse model. Muc2/p21 double mutant mice with a selenium-enriched (sodium selenite) diet for 12 or 24 weeks, found sodium selenite inhibited tumor formation in these animals (p < 0.01), which was associated phosphorylation JNK1 suppression beta-catenin COX2. vitro showed promoted cell...
Abstract To investigate the astrocyte elevated gene‐1 (AEG‐1) expression and its relationship with clinicopathological features of colorectal carcinoma (CRC) β‐catenin signaling pathway. Real‐time PCR, Western blot, immunohistochemistry, immunofluorescence staining were performed to detect AEG‐1 in CRC cell lines, 8 pairs fresh adjacent nontumor tissues (ANT), 120 paraffin‐embedded specimens ANT tissues, 60 samples lymph node metastatic tissues. Scratch wound assay transwell matrix...
Remarkable strides in computational pathology have been made the task-agnostic foundation model that advances performance of a wide array downstream clinical tasks. Despite promising performance, there are still several challenges. First, prior works resorted to either vision-only or vision-captions data, disregarding invaluable reports and gene expression profiles which respectively offer distinct knowledge for versatile applications. Second, current progress FMs predominantly concentrates...