A5010498824- Gastric Cancer Management and Outcomes
- Enhanced Recovery After Surgery
- Esophageal and GI Pathology
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer Research and Treatments
- Cancer, Stress, Anesthesia, and Immune Response
- ZnO doping and properties
- Respiratory Support and Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Semiconductor materials and devices
- Cancer Mechanisms and Therapy
- Sarcoma Diagnosis and Treatment
- Estrogen and related hormone effects
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Metal and Thin Film Mechanics
- Cancer, Lipids, and Metabolism
- Colorectal Cancer Screening and Detection
- Nutrition and Health in Aging
Sun Yat-sen University
2014-2024
Jiangnan University
2022-2024
Wuxi Fourth People's Hospital
2022-2024
University of Kansas Medical Center
2024
Sun Yat-sen University Cancer Center
2020-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2022-2024
Key Laboratory of Guangdong Province
2022-2023
The First Affiliated Hospital, Sun Yat-sen University
2013-2023
Beijing Friendship Hospital
2020
Capital Medical University
2020
Berberine (BBR) is a compound originally identified in Chinese herbal medicine Huanglian (Coptis chinensis French). It improves glucose metabolism type 2 diabetic patients. The mechanisms involve activation of adenosine monophosphate activated protein kinase (AMPK) and improvement insulin sensitivity. However, it not clear if BBR reduces blood through other mechanism. In this study, we addressed issue by examining liver response to rats, which hyperglycemia was induced Sprague-Dawley rats...
The extracellular matrix (ECM) has been demonstrated to be dysregulated and crucial for malignant progression in gastric cancer (GC), but the mechanism is not well understood. Here, that discoidin domain receptor 1 (DDR1), a principal ECM receptor, recognized as key driver of GC reported. Mechanistically, DDR1 directly interacts with PAS hypoxia-inducible factor-1α (HIF-1α), suppresses its ubiquitination subsequently strengthens transcriptional regulation angiogenesis. Additionally,...
Few clinical studies or randomized trial results have reported the impact of fast-track surgery on human immunity. This study aimed to investigate and immune in colorectal cancer patients undergoing elective open surgery.A controlled was conducted from November 2008 January 2009 with a 1-month postdischarge follow-up. A total 70 carcinoma requiring resection were into two groups: group (35 cases) conventional care cases). All included underwent combined tracheal intubation general...
// Tiantian Zhen 1,* , Sujuan Dai Hui Li Yang Lili Kang 1 Huijuan Shi Fenfen Zhang Dongjie 2 Shirong Cai Yulong He Yingjie Liang and Anjia Han Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China Gastrointestinal Surgery, * These authors contributed equally to this work Correspondence: Han, email: Keywords : MACC1, β-catenin, colorectal cancer, carcinogenesis Received February 7, 2014 Accepted May 18, Published 20, Abstract Here we confirmed...
DJ-1 and PTEN have been shown to involve in multiple cell processes play an important role cancer development progression. However, their relationship with gastric carcinoma (GC) has not identified yet. The purpose of this study is clarify the phosphatase tensin homolog (PTEN) clinicopathological parameters prognosis GC.114 specimens were collected from GC patients expression tissue microarray was evaluated by immunohistochemical staining. Correlation between immunostainings parameters,...
Biomimetic nanoparticles represent a promising avenue for mitigating rapid clearance by the reticuloendothelial system (RES); however, current challenges include insufficient tumour targeting, suboptimal adhesion, and inadequate localized drug release within regions. These shortcomings contribute to persistent contests, such as recurrence pulmonary metastasis, even with advanced breast cancer therapies. Stimuli-sensitive can furbish membrane coated their efficiency against stated problems....
The role of estrogen receptor alpha (ERa), beta (ERb) and ERa36 signaling in hepatocellular carcinoma (HCC) is not fully addressed. In this study, three cohorts were included: (i) primary HCC patients (N = 76, cohort P), (ii) colorectal liver metastasis (mCRC) 32, S), (iii) from Cancer Genome Atlas (TCGA) 121). levels wtER36 measured their correlation with clinicopathologic features was determined. WtERa downregulated that upregulated tumor tissues both P TCGA data set. S. P, wtERa...
Aim: Altered long noncoding RNA (lncRNA) and mRNA is vital in the progression from Helicobacter pylori (H. pylori, HP) infection to gastric cancer (GC) mucosa-associated lymphoid tissue (MALT) lymphoma. Materials & methods: Five independent Gene Expression Omnibus datasets (GSE5081, GSE84433, GSE15459, GSE66229 GSE25638) were included our study. Results: Differentially expressed lncRNAs mRNAs both H. pylori-positive gastritis GC tissues identified. Using two cohorts, pylori-related DYNC1I1...
Gastric cancer is the third leading cause of death worldwide. In this study, we tried to clarify function KLF5 in gastric cancer. Copy number variation (CNV) and expression were interrogated public datasets. The clinical significance amplification gene evaluated. cell proliferation was studied lines organoids. We found that mainly occurred chromosome instable tumors (CIN) significantly associated with TP53 mutation. addition, higher correlated more locally invasive T stage. Next, a signature...
Although many studies have indicated that high-mobility group box 1 protein (HMGB1) is associated with oncogenesis and a worse prognosis, the prognostic value of HMGB1 in gastric cancer (GC) remains unclear. In present work, we aimed to evaluate role GC examined whether aberrant expression both vascular endothelial growth factor C (VEGF-C) increased malignant potential GC. A total 166 patients 32 normal subjects were enrolled. VEGF-C was detected by tissue microarrays (TMAs)...
BACKGROUND:Acute respiratory distress syndrome (ARDS) is a sudden and serious disease with increasing morbidity mortality rates. Phosphodiesterase 4 (PDE4) novel target for inflammatory disease, ibudilast (IBU), PDE4 inhibitor, inhibits response. Our study investigated the effect of IBU on pathogenesis neonatal ARDS underlying mechanism related to it. MATERIAL AND METHODS:Western blotting was performed analyze expression levels PDE4, CXCR4, SDF-1, CXCR5, CXCL1, cytokines, proteins cell...
<b>BACKGROUND AND PURPOSE:</b> The outcome for simultaneous revascularization of more than 1 supra-aortic arterial stenosis has not been evaluated because concerns regarding the increased risk additional procedures. We feasibility and safety concomitant multiple revascularizations (CMSAR). <b>MATERIALS METHODS:</b> retrospectively 50 consecutive patients who underwent CMSARs with angioplasty stent placement. study included a separate lesion group (LG) (<i>n</i> = 28), ipsilateral LG 17)...
Our study investigated the significance of crosstalk between long noncoding RNAs (lncRNAs) and mRNAs in gastric cancer (GC). lncRNA mRNA expression profiling data 671 GC tumors 77 nontumorous tissues were retrieved from gene omnibus database: GSE54129, GSE13911, GSE19826, GSE79973, GSE15459 GSE66229. Differentially expressed analysis, RNA coexpression network construction, ontology (GO) Kyoto encyclopedia genes genomes (KEGG) enrichment analyses conducted this study. Using differentially...
Aim: We performed a study to identify the role of microRNA in thymoma. Patients & methods: One hundred twenty-three thymoma patients with clinical information and miRNA expression data from The Cancer Genome Atlas were included study. Comprehensive bioinformatics analysis was integrated our analysis. Results conclusion: Seven miRNAs found be associated overall survival (p < 0.001). Another four disease-free Type C can distinguished nontype by miRNAs. Interestingly, seven showed both...
The platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte (NLR) have been found to be associated with prognosis in several solid tumours. However, the prognostic roles of PLR NLR gastrointestinal stromal tumours (GISTs) remain controversial. aim this meta-analysis was assess GISTs.We searched MEDLINE, EMBASE Cochrane Library for relevant articles. A systematic review performed calculate pooled hazard ratios (HRs) disease-free survival (DFS) overall (OS) by...