A5015880471- Pancreatic and Hepatic Oncology Research
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- RNA modifications and cancer
- Gallbladder and Bile Duct Disorders
- Gut microbiota and health
- Oral Health Pathology and Treatment
- Biliary and Gastrointestinal Fistulas
- Antibiotic Use and Resistance
- Cancer therapeutics and mechanisms
- Esophageal Cancer Research and Treatment
- Renal and related cancers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Telomeres, Telomerase, and Senescence
- Probiotics and Fermented Foods
- Autoimmune Bullous Skin Diseases
- Animal Genetics and Reproduction
- Inflammatory Bowel Disease
- Antimicrobial Resistance in Staphylococcus
- Nosocomial Infections in ICU
- Microbial Metabolites in Food Biotechnology
- Heme Oxygenase-1 and Carbon Monoxide
- Helicobacter pylori-related gastroenterology studies
- Plant-based Medicinal Research
Shanghai Changzheng Hospital
2021-2025
Heilongjiang Bayi Agricultural University
2024
Anhui Medical University
2018-2024
First Affiliated Hospital of Anhui Medical University
2024
First Affiliated Hospital of Kunming Medical University
2021
Kunming Medical University
2021
Massachusetts General Hospital
2019
Harvard University
2019
The First Affiliated Hospital, Sun Yat-sen University
2010-2018
Sun Yat-sen University
2010-2018
The adenosine diphosphate (ADP) receptor P2RY12 (purinergic P2Y, G protein coupled, 12) plays a critical role in platelet aggregation, and inhibitors are used clinically to prevent cardiac cerebral thrombotic events. Extracellular ADP has also been shown increase osteoclast (OC) activity, but the of OC biology is unknown. Here, we examined mouse function. Mice lacking P2ry12 had decreased activity were partially protected from age-associated bone loss. P2ry12-/- OCs exhibited intact...
Background: Growing evidence indicates that heme oxygenase-1 (HO-1) is up-regulated in malignancies and subsequently alters tumor aggressiveness various cancer-related factors, such as high glucose (HG) levels. HO-1 expression can be induced when concentrations are above 25 mM; however, the role of lung cancer patients with diabetes remains unknown. Therefore, this study we investigated promotion cell invasion metastasis-associated proteins by inducing up-regulation HG treatment A549 human...
To explore the mechanism of hypoglycemic effect BQP in type 2 diabetic mice induced by combination high-fat diet (HFD) and streptozotocin (STZ). Treatment with significantly ameliorated blood glucose lipid levels improved oxidative stress liver injury levels. The results intestinal flora study showed that concentration short-chain fatty acids (SCFAs) cecum contents group was higher than those mice. treatment microbial disorders feces, altered diversity flora, reduced Bacteroidota to...
Background MR enterography (MRE) is the primary modality for evaluating small bowel disease in pediatric Crohn's patients. Standard clinical practice includes imaging patients at diagnosis and during symptomatic recurrence. The role MRE surveillance of asymptomatic has not yet been established. Purpose To determine whether features are associated with Study Type Retrospective. Populations Pediatric who underwent while asymptomatic, defined by gastroenterologists using a physician global...
The purse string-stapled anastomotic technique is a method for minimally invasive oesophagectomy with intrathoracic anastomosis, in which string hand sewn without the necessity of specialized devices, such as OrVil and Endo-Stitch. Since this was first reported by our surgical team 2012, several measures operation have been refined. Furthermore, there are very few literature reports on major complications technique. This article studies Ivor Lewis explores methods prevention...
Our study investigated the significance of crosstalk between long noncoding RNAs (lncRNAs) and mRNAs in gastric cancer (GC). lncRNA mRNA expression profiling data 671 GC tumors 77 nontumorous tissues were retrieved from gene omnibus database: GSE54129, GSE13911, GSE19826, GSE79973, GSE15459 GSE66229. Differentially expressed analysis, RNA coexpression network construction, ontology (GO) Kyoto encyclopedia genes genomes (KEGG) enrichment analyses conducted this study. Using differentially...
To investigate the dynamic changes in high-resolution computed tomography (HRCT) findings of coronavirus disease 2019 (COVID-19) patients with different severities stages.We retrospectively collected clinical and imaging data 96 Yunnan Province, China, who were diagnosed COVID-19 between January 22 March 15, 2020. Based on severity, classified into four types: mild (n=15), moderate (n=59), severe (n=19), critical (n=3). hospital stay number (CT) scans, clinical/disease course was divided...
Background: The esophageal mixed neuroendocrine–non-neuroendocrine neoplasm (MiNEN) is an extremely rare but poor prognosis tumor. Objectives: This retrospective study aimed to analyze the clinical characteristics of MiNEN and investigate postoperative survival prognostic factors. Design: analyzed 69 patients diagnosed with at two major cancer centers in China from January 2000 December 2021. Methods: We assessed demographic data, tumor characteristics, treatment modalities, outcomes....
Objective To develop and validate an interactive nomogram to predict healthcare-associated infections (HCAIs) in the intensive care unit (ICU). Methods A multicenter retrospective study was conducted review 2017 data from six hospitals Guizhou Province, China. total of 1,782 ICU inpatients were divided into either a training set (n = 1,189) or validation 593). The patients’ demographic characteristics, basic clinical features previous admission, their need for bacterial culture during...
Objective: To investigate the roles of p38 mitogen-activated protein kinases (p38 MAPK) , extracellular regulated (ERK) and c-Jun N-tenninal (JNK) MAPK signaling pathway in Paraquat-induced epithelial to mesenchymal transition (EMT) type II alveolarepithelial cells. Methods: RLE-6NT cells were incubated with different concentrations PQ (0, 25, 50, 100μmol/L) for 6, 12 24 h. Cell morphology alteration was observed under phase-contrast microscopy. viability determined using an MTT assay....
Objective To compare the feasibility and safety of pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy. Methods A retrospective study was performed on 37 patients who underwent pancreaticoduodenectomy for duodenal carcinoma or pancreatic head tumors at First Hospital Sun Yat-sen University from April 2006 to December 2010.Pancreatic anastomosis carried out either using (n＝ 19) (n=18).The operative time,intraoperative bHood Hoss,postoperative Heak,mortaHity...
Objective To study the feasibility, safety and clinical effects of spleen splenic vessel-preserving distal pancreatectomy. Methods A retrospective was performed in 26 patients undergoing pancreatectomy for benign or low grade malignant disease with splenectomy (n = 13) preservation 13 ) at First Hospital Sun Yat-sen University Guangdong General from May 2002 to April 2009. Results All were successfully. There no statistically significant difference between two groups average operative...
Objective To investigate the effect of inhibiting human telomerase reverse transcriptase (hTERT) gene by small interfering RNA (siRNA) interference on proliferation gastric cancer SGC7901 cells.Methods The recombinant plasmids containing hTERT target sequences were transfected into cells LipofectamineTM 2000.The expression was detected FQ-polymerase chain reaction (PCR) quantitatively.The activity tested TRAP-PCR.The determined using methylthiazol tetrazolium (MTr) assay.Results After...