A5101863231- Pancreatitis Pathology and Treatment
- Cancer-related molecular mechanisms research
- Liver Disease Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Medical Research and Treatments
- Radioactive element chemistry and processing
- High-Temperature Coating Behaviors
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Nuclear Materials and Properties
- Diabetes and associated disorders
- Lung Cancer Treatments and Mutations
- Sphingolipid Metabolism and Signaling
- Regional Development and Environment
- Signaling Pathways in Disease
- Bone Metabolism and Diseases
- Shoulder and Clavicle Injuries
- Cytokine Signaling Pathways and Interactions
- Biochemical and Structural Characterization
- Pelvic and Acetabular Injuries
- Abdominal Trauma and Injuries
- Inflammatory Biomarkers in Disease Prognosis
- Lymphatic Disorders and Treatments
Shanghai University
2024
Shanghai Research Institute of Materials
2024
Hainan Medical University
2021-2024
Sun Yat-sen University
2012-2021
Fifth Affiliated Hospital of Sun Yat-sen University
2012-2021
82th Hospital of Pla
2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Sichuan University
2008-2015
West China Hospital of Sichuan University
2008-2010
Agostino Gemelli University Polyclinic
2008
To clarify the roles of organ failure and infection in outcome necrotizing pancreatitis.Results previous cohort studies that focused on acute pancreatitis are controversial.In this study, we collected medical records 447 patients with from January 2009 to June 2012. Data associated were analyzed.The overall mortality rate was 13% (58/447). Intervention performed 223 patients. Among these patients, 134 confirmed be infected necrosis by a positive culture. The 15% (13/89) sterile group 18%...
miR-218-5p is an extensively studied microRNA (miRNA) in prostate cancer (PCa). However, the clinical significance and biological role of bone metastasis PCa remain unclear.miR-218-5p expression was evaluated 38 metastatic 115 non-bone tissues serum samples. Clinical correlation with clinicopathological characteristics analyzed. The roles were investigated vitro by invasion migration assays. Bioinformatics analysis, real-time polymerase chain reaction, western blot, luciferase reporter assay...
Osteosarcoma is a primary malignant bone tumor that has high potential to metastasize lungs. Little known about the mechanisms underlying dissemination of OS cancer cells We performed whole exome sequencing 13 tumors, with matched lung metastases and normal tissues. Phylogenetic analyses revealed metastatic tumors often harbor clones are nonexistent or rare in tumors. Spatially temporally separated were from parallel seeding events polyphyletic pattern. Loss TP53 RB1 among early during...
Early treatment with AGD achieved a better clinical outcome in SAP patients.
This study aimed to conduct a single-center prospective trial of short-term continuous high-volume hemofiltration (HVHF) in patients with predicted severe acute pancreatitis (SAP).Patients Acute Physiology and Chronic Health Evaluation II scores greater than 15 on admission between January 2008 December 2010 were allocated receive either optimal standard therapy or 72 hours HVHF an alternate basis, beginning as soon possible after admission. Biomarkers clinical outcomes compared the 2...
Recent studies revealed that microRNAs (miRNAs) may play crucial roles in the responses and pathologic processes of spinal cord injury (SCI). This study aimed to investigate effect molecular basis miR-103 on LPS-induced injuries PC12 cells vitro SCI rats vivo.PC12 were exposed LPS induce cell mimic model SCI. The expression SOX2 altered by transient transfections. Cell viability apoptotic rate measured CCK-8 assay flow cytometry assay. Furthermore, Western blot analysis was performed detect...
Qing-Yi Decoction (QYD) has been used for severe acute pancreatitis (SAP) patients in China many years. There were two kinds of QYD: Num 1. QYD (QYD1) which is the response stage SAP and 2. (QYD2) second SAP. This study aims to evaluate therapeutic efficacy participants with In this prospective, randomized, double-blind, placebo-controlled trial, aged 18–70 years within first 7 days after onset typical abdominal pain (the definition was according 2007 Guidelines Management Severe Acute...
Paxilitaxel, a drug used in cancer chemoprevention and treatment, has shown promising anti‑cancer effects against broad spectrum of tumors. However, the effect paxilitaxel on osteoblasts remained to be elucidated. The aim present study was investigate anti‑tumor human osteosarcoma cells, underlying molecular mechanism as well resistance involved. results showed that not only induced apoptosis via mitochondrial pathway but also autophagy, which partially inhibited cell apoptosis. demonstrated...
Background: Lung cancer is the leading cause of cancer-related death, and adenocarcinoma most common type lung cancer. Although emerging evidence implicates role several aldehyde dehydrogenases in progression, expression clinical significance dehydrogenase 3B1 has never been studied. Materials: In our study, 250 cases was detected with immunohistochemistry, patients were further divided into subgroups different expression. Using real-time polymerase chain reaction, we investigated messenger...
Objective: To assess the effect of Traditional Chinese Medicine (TCM) nutrition treatment (Bushenhuoxue nutritional decoction) in overweight patients with polycystic ovary syndrome (PCOS). Methods: Retrospective analysis 96 PCOS who received our hospital from October 2020 to June 2022 was done. Among them, 46 routine drug and daily dietary intervention (control group), while 50 additional TCM support addition (observation group). Glucose lipid metabolism indicators hormone levels were...
BACKGROUND Osteoclast formation is closely related to the immune system. FTY720, a new immunosuppressive agent, has some functions in regulation. Its main active ingredients become FTY-720P vivo by phosphorylation modification. The objective of this study was determine effects FTY-720 with various concentrations on osteoclasts vitro. MATERIAL AND METHODS RAW264.7 cells and bone marrow-derived mononuclear phagocytes (BMMs) were treated RANKL obtain To investigate role osteoclast formation,...
Osteoporosis, a common skeletal disorder mainly affecting postmenopausal women, is characterized by the imbalance between osteogenesis and osteoclastogenesis. Circ_0134944 has been recently found to be upregulated in osteoporosis (PMOP) patients. However, its role remains unknown. Here we aimed explore of circ_0134944 reveal underlying mechanism. qRT-PCR was used determine expression circ_0134944, miR-127-5p, PDX1 SPHK1 blood mononuclear cells (BMCs) PMOP Bone marrow mesenchymal stem (BMSCs)...
The aim of this study was to establish a quality-control method for calcineurin subunit B (CNB) biological activity determinations. CNB enhances the p-nitrophenylphosphate (pNPP) dephosphorylating A Δ316 mutant (CNAΔ316). series concentrations were fitted four-parameter equation calculate corresponding pNPP maximum dephosphorylation rates. Values calculated based on references using parallel line method. then validated accuracy, precision, linearity, linear range, sensitivity, specificity,...