A5101738661- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Animal Virus Infections Studies
- RNA Research and Splicing
- RNA modifications and cancer
- Osteoarthritis Treatment and Mechanisms
- Cancer, Hypoxia, and Metabolism
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- Viral gastroenteritis research and epidemiology
- Immune cells in cancer
- Sirtuins and Resveratrol in Medicine
- Histone Deacetylase Inhibitors Research
- interferon and immune responses
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Genomics and Rare Diseases
- Peroxisome Proliferator-Activated Receptors
- Chemotherapy-induced cardiotoxicity and mitigation
Jiangyin People's Hospital
2025
Nantong University
2025
Nanjing University
2013-2025
Fudan University Shanghai Cancer Center
2017-2025
Fujian Agriculture and Forestry University
2017-2025
Shanghai Medical College of Fudan University
2025
Shanghai Jiao Tong University
2011-2024
Shanghai First People's Hospital
2016-2024
State Key Laboratory of Genetic Engineering
2024
Huazhong University of Science and Technology
2019-2024
Trastuzumab resistance is leading cause of mortality in HER2-positive breast cancers, and the role TGF-β-induced epithelial-mesenchymal transition (EMT) trastuzumab well established, but involvement lncRNAs still unknown. Here, we generated trastuzumab-resistant cancer cells with increased invasiveness compared parental cells, observed robust consistently elevated TGF-β signaling these cells. We identified long noncoding RNA activated by (lnc-ATB) was most remarkably upregulated lncRNA TR...
Long noncoding RNAs (lncRNAs) play important roles in regulating the development and progression of many cancers. However, clinical significance specific lncRNAs context nasopharyngeal carcinoma (NPC) molecular mechanisms by which they regulate this form cancer remain largely unclear. In study we found that lncRNA PVT1 was upregulated NPC, patients upregulation associated with reduced survival. RNA sequencing revealed responsible for NPC cell proliferation controlling a hypoxia-related...
ABSTRACT Compared to fluorescence imaging, chemiluminescence imaging does not need external excitation light, and hence presents high depth signal‐to‐noise ratio without autofluorescence phototoxicity, making it a promising tool for biological detection analysis. However, the target‐specific activatable near‐infrared emission chemiluminescent probes still be developed precise diagnosis of diseases. In this paper, we synthesized four direct Schaap's chemiluminophores (AINCL, AIFCL, ABTCL,...
Aberrant SMAD3 activation has been implicated as a driving event in cancer metastasis, yet the underlying mechanisms are still elusive. Here, is identified nonhistone substrate of lysine acetyltransferase 6A (KAT6A). The acetylation at K20 and K117 by KAT6A promotes association with oncogenic chromatin modifier tripartite motif-containing 24 (TRIM24) disrupts interaction tumor suppressor TRIM33. This turn KAT6A-acetylated H3K23-mediated recruitment TRIM24-SMAD3 complex to thereby increases...
Analysis of extracellular vesicles (EV) is a promising noninvasive liquid biopsy approach for breast cancer detection, prognosis, and therapeutic monitoring. A comprehensive understanding the characteristics proteomic composition cancer-specific EVs from human samples required to realize potential this strategy. In study, we applied mass spectrometry-based, data-independent acquisition characterize serum derived patients with (n = 126) healthy donors 70) in discovery cohort validated...
Abstact Conventional therapies and novel molecular targeted against breast cancer have gained great advances over the past two decades. However, poor prognosis low survival rate are far from expectation for improvement, particularly in patients with triple negative (TNBC). Here, we found that lncRNA DANCR was significantly overregulated TNBC tissues cell lines compared normal or other type of cancer. Knockdown suppressed proliferation both vitro vivo. Further study underlying mechanisms...
Despite the development of adjuvant therapies, glioblastoma (GBM) patients remain incurable, thus justifying urgent need new therapies. CDK5 plays a critical role in GBM and is potential target for GBM. However, mechanism by which promotes tumorigenicity remains largely unknown. Here, we identify TRIM59 as substrate CDK5. EGFR-activated directly binds to phosphorylates TRIM59, ubiquitin ligase at serine 308, recruits PIN1 cis-trans isomerization leading binding importin α5 nuclear...
Glioblastoma (GBM) is the most lethal primary brain tumor in adults with a median survival of around 15 months.A potential treatment strategy involves targeting glioma stem-like cells (GSCs) that are able to initiate, maintain, and repopulate mass.Here, we identify ACT001, parthenolide derivative, GSCs through regulation adipocyte enhancer binding protein 1 (AEBP1) signaling.Methods: The effects ACT001 on cell normal human astrocytes (NHA) patient-derived were evaluated.RNA-Seq performed...
// Bo Yu 1, 2, * , Qiong Du Huan Li 2 Hong-Yue Liu Xuan Ye Bin Zhu Qing Zhai and Xin-Xiang 3 1 Department of Oncology, Shanghai Medical College, Fudan University, 200032, China Pharmacy, University Cancer Center, Colorectal Surgery, These authors contributed equally to this work Correspondence to: Zhai, email: zhaiqing63@126.com Li, lxx1149@163.com Keywords: colorectal carcinoma, exosome, CRNDE-p, miR-217 Received: March 01, 2017 Accepted: July 12, Published:...
Abstract Background According to the International Multidisciplinary Classification of Lung Adenocarcinoma (LAD) by Association for Study Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) in 2011, diagnosis LAD is changing from simple morphology into a comprehensive multidisciplinary classification. The aim this study detect expression Notch-1 and analyze its clinicopathological or prognostic significance different histological subtypes Adenocarcinomas (LADs)....
Abstract Background This present study aimed to investigate the correlation of long non‐coding RNA THRIL (lnc‐THRIL) with acute respiratory distress syndrome (ARDS) risk, disease severity, inflammation, and mortality in sepsis patients. Methods A total 109 patients admitted intensive care units were consecutively recruited, their blood samples collected. After admission, supervised screened daily identify occurrence ARDS. Clinical characteristics, routine laboratory testing, severity...
This study aims to assess whether dual anti-HER2 therapy with trastuzumab and pertuzumab increases early cardiac toxicity compared alone in breast cancer (BC) patients receiving postoperative radiation (RT). Consecutive operable BC RT or without between January 2017 September 2020 at seven tertiary hospitals China were retrospectively reviewed. Cardiac examinations included echocardiography, electrocardiogram (ECG), NT-proBNP, cTnI baseline before during the follow-up. The event is any...
Interspecific hybridization serves as a crucial strategy for innovating sugarcane germplasms. Currently, nearly all modern varieties that incorporate genetic material are derived from Saccharum spontaneum. The number of chromosomes in S. spontaneum ranges 40 to 128, contributing significantly the diversity its resources. However, mechanisms driving chromosome variation remain be fully elucidated. Here, oligonucleotide fluorescence situ (Oligo-FISH) was conducted identify individual and...
The objective of this study was to investigate whether skeletal muscle cystathionine γ-lyase (CTH) contributes high-fat diet (HFD)-induced metabolic disorders using