A5053605383- Osteoarthritis Treatment and Mechanisms
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Inflammatory mediators and NSAID effects
- HIV/AIDS drug development and treatment
- Knee injuries and reconstruction techniques
- Cell Adhesion Molecules Research
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Extracellular vesicles in disease
- Hippo pathway signaling and YAP/TAZ
- Immune cells in cancer
- Protease and Inhibitor Mechanisms
- Antimicrobial Resistance in Staphylococcus
- Medical Imaging and Pathology Studies
- Chemokine receptors and signaling
- Cytokine Signaling Pathways and Interactions
- Ubiquitin and proteasome pathways
- Congenital Diaphragmatic Hernia Studies
- Periodontal Regeneration and Treatments
- Sex work and related issues
- Infectious Diseases and Mycology
- Temporomandibular Joint Disorders
- Enterobacteriaceae and Cronobacter Research
- Adipose Tissue and Metabolism
Kunming Medical University
2025
University of Pennsylvania
2020-2024
Guangzhou University of Chinese Medicine
2024
First Affiliated Hospital of Jinan University
2016-2024
Jinan University
2013-2021
Institute of Microbiology
2014-2019
Tongji University
2012-2016
Shanghai Pulmonary Hospital
2005-2016
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2016
EGFR activation by overexpressing HBEGF in cartilage or intra-articular delivery of TGFα nanoparticles attenuates osteoarthritis development mice.
The engineered nanoparticles mitigate osteoarthritis progression.
Abstract The interplay between immune cells/macrophages and fibroblast‐like synoviocytes (FLSs) plays a pivotal role in initiating synovitis; however, their involvement metabolic disorders, including diabetic osteoarthritis (DOA), is largely unknown. In this study, single‐cell RNA sequencing (scRNA‐seq) employed to investigate the synovial cell composition of DOA. A significant enrichment activated macrophages within eight distinct clusters found DOA synovium. Moreover, it demonstrated that...
Osteoarthritis (OA) affects multiple tissues in the knee joint, including synovium and intra-articular adipose tissue (IAAT) that are attached to each other. However, whether these two share same progenitor cells hence function as a single unit joint homeostasis diseases is largely unknown. Single-cell transcriptomic profiling of infrapatellar fat pad (IFP), largest IAAT, from control OA mice revealed five mesenchymal clusters predicted (MPCs) common progenitors for other cells: synovial...
Chondrosarcoma, the second-most frequent primary bone malignancy, is generally more resistant to conventional chemotherapy and radiotherapy. Therefore, development of an effective adjuvant therapy necessary. Recently, targeting epigenetic regulator such as bromodomain extraterminal domain (BET) proteins has achieved great success. For instance, inhibitor JQ1 been shown inhibit growth several cancer cells both in vitro vivo. Herein, we demonstrated that significantly inhibited chondrosarcoma...
The objective of this study was to investigate the effect botulinum toxin type A (BTX-A)-induced quadriceps muscle atrophy on cartilage and subchondral bone in an otherwise intact rat joint model.The right established by intramuscular injection BTX-A. Twenty-four rats were divided randomly into 3 groups: BTX-A-treated 4-week group; 8-week control group injected with phosphate buffer saline observed for 8 weeks. Muscle level measured weighing histology examinations. Serum interleukin-1β...
Chondrosarcoma (CHS) is the second most common bone malignancy with limited therapeutic approaches. Our previous study has found that Yes associated protein 1 (YAP1) downregulated in CHS cells treated bromodomain and extraterminal domain (BET) inhibitor JQ1. However, precise role of YAP1 largely unknown. Herein, we expression was upregulated tissues, positively correlated its grading score. Loss inhibited proliferation induced cellular senescence, while mutants revealed YAP1/TEA family...
BACKGROUND: Stroke causes somatic dysfunction and psychological disorders, leading to poststroke depression (PSD). This study investigates mood alterations in PSD models via cerebellar intermittent theta burst stimulation (iTBS). METHODS: animal were developed using middle cerebral artery occlusion chronic unpredictable mild stress procedures. underwent iTBS with different pulse numbers. Neurological recovery was evaluated open-field test, sucrose preference forced swimming balance beam...
ABSTRACT Chondrosarcoma is the second most malignant bone tumor with poor prognosis and limited treatment options. Thus, development of more effective treatments has become urgent. Recently, natural compounds derived from medicinal plants have emerged as promising therapeutic options via targeting multiple key cellular molecules. Andrographolide (Andro) such a compound, which previously been shown to induce cell cycle arrest apoptosis in several human cancers. However, molecular mechanism...
ABSTRACT The uppermost superficial zone of articular cartilage is the first line defense against initiation osteoarthritis (OA). We previously used Col2-Cre to demonstrate that epidermal growth factor receptor (EGFR), a tyrosine kinase receptor, plays an essential role in maintaining chondrocytes during development. Here, we showed EGFR activity decreased as mice age. In mouse and human OA samples, was initially reduced at layer then resurged cell clusters within middle deep late OA. To...
Meniscal tears are associated with a high risk of osteoarthritis but currently have no disease-modifying therapies. Using Gli1 reporter line, we found that + cells contribute to the development meniscus horns from 2 weeks age. In adult mice, resided at superficial layer and expressed known mesenchymal progenitor markers. culture, meniscal possessed activities under control Hh signal. Meniscus injury anterior horn induced quick expansion Gli1-lineage cells. Normally, tissue healed slowly,...
The rapid spreading of HIV drug resistance is threatening the overall success free HAART in China. Much work has been done on drug-resistant mutations, however, most which were based subtype B. Due to different genetic background, subtypes difference would have an effect development already proved by more and studies. In China, main epidemic are CRF07_BC, CRF08_BC, Thai B CRF01_AE. depiction mutations those will be helpful for selection regimens Chinese. this study, distributions amino acids...
Abstract Type 2 diabetes mellitus (T2DM) is increasingly being recognized as an independent risk factor for the onset and progression of osteoarthritis (OA). Extensive studies have focused on contribution obesity (excessive mechanical stress), comorbidity frequently found in T2DM, to cartilage destruction during OA development. However, a little known about how diabetes‐related inflammation may affect local diabetic objective. In present study, we were able establish T2DM rat model using...
Shenzhen City is a rapidly growing area with large number of floating populations, thus making it difficult to control HIV. Serial cross-sectional studies are helpful for the prediction epidemiological tendency. In this study, two parallel were compared explore changes in HIV epidemiology Shenzhen, China.Two hundred and fifty newly reported HIV-positive cases randomly selected 2013 2015. Socio-demographical information was collected informed consent. Full-length gag partial pol genes...
ABSTRACT Posttraumatic osteoarthritis (PTOA) results in joint pain, loss of function, and impaired quality daily life patients with limited treatment options. We previously demonstrated that epidermal growth factor receptor (EGFR) signaling is essential for maintaining chondroprogenitors during articular cartilage development homeostasis. Here, we used a nonsurgical, loading-induced PTOA mouse model to investigate the protective action EGFR signaling. A single bout cyclic tibial loading at...