A5044529695- Circular RNAs in diseases
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Bone Metabolism and Diseases
- Shoulder and Clavicle Injuries
- Trauma Management and Diagnosis
- Shoulder Injury and Treatment
- Autophagy in Disease and Therapy
- Immune cells in cancer
- RNA modifications and cancer
Guangzhou University of Chinese Medicine
2021-2025
Circular RNA (CircRNA) plays a potential role in bone formation. We aimed to study the circRNAs expression profiles and their functions osteogenic differentiation of human marrow stromal cells (BMSCs). Firstly, we established BMSCs displaying increased mRNA marker (RUNX2, OPN, OCN), ALP activity protein expression, mineralized nodules formation, as well morphological alteration. Then, employed high-throughput sequencing analyze circRNA found that 3440 3893 non-induced induced groups,...
Abstract Background Circular RNAs (circRNAs) are a new type of stable noncoding RNA and have been proven to play crucial role in osteoporosis. This study explored the mechanism hsa_circ_0001485 osteogenic differentiation. Methods Kyoto Encyclopedia Genes Genomes (KEGG) analysis Gene Ontology (GO) enrichment were performed according previous sequencing data human bone marrow mesenchymal stem cells (BMSC) before after induction differentiation on differentially expressed circRNAs, screen out...
<title>Abstract</title> Synovitis is often associated with osteoarthritis (OA) and may even precede the onset of OA symptoms. Although targeting synovial inflammation has shown therapeutic promise in OA, synovium's heterogeneous composition, multiple cell types contributing to inflammatory response, indicates that focusing on a single population not provide most favorable results. This investigation employed scRNA-seq tissues from both human murine sources, revealing fibroblasts macrophages...