A5090854351- Autophagy in Disease and Therapy
- Kruppel-like factors research
- Adsorption and biosorption for pollutant removal
- Sirtuins and Resveratrol in Medicine
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Advanced Photocatalysis Techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- TiO2 Photocatalysis and Solar Cells
- Catalytic Processes in Materials Science
- Caveolin-1 and cellular processes
- Microtubule and mitosis dynamics
- RNA Research and Splicing
- RNA modifications and cancer
- Heavy metals in environment
- Environmental remediation with nanomaterials
- Cancer, Lipids, and Metabolism
- Biochemical and Molecular Research
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- MicroRNA in disease regulation
- Extracellular vesicles in disease
Shanghai Jiao Tong University
2016-2025
Shanghai First People's Hospital
2016-2025
Shanghai Clinical Research Center
2021-2025
Northeastern University
2020-2024
Bridge University
2022
State Key Laboratory of Oncogene and Related Genes
2022
East China Normal University
2013-2016
Abstract Cuproptosis, caused by excessively high copper concentrations, is urgently exploited as a potential cancer therapeutic. However, the mechanisms underlying initiation, propagation, and ultimate execution of cuproptosis in tumors remain unknown. Here, we show that content significantly elevated gastric (GC), especially malignant tumors. Screening reveals METTL16, an atypical methyltransferase, critical mediator through m 6 A modification on FDX1 mRNA. Furthermore, stress promotes...
Cancer-associated fibroblasts (CAFs) are abundant stromal cells in the tumor microenvironment that promote cancer progression and relapse. However, heterogeneity regulatory roles of CAFs underlying chemoresistance remain largely unclear. Here, we performed a single-cell analysis using high-dimensional flow cytometry identified distinct senescence-like tetraspanin-8 (TSPAN8)
Abstract Mortality rates due to lung cancer are high worldwide. Although PD‐1 and PD‐L1 immune checkpoint inhibitors boost the survival of patients with non‐small‐cell (NSCLC), resistance often arises. The Warburg Effect, which causes lactate build‐up potential lysine‐lactylation (Kla), links dysfunction tumor metabolism. role non‐histone Kla in microenvironment immunotherapy remains be clarified. Here, global lactylome profiling metabolomic analyses samples from NSCLC is conducted. By...
Centrosome amplification is frequent in cancer, but the underlying mechanisms remain unclear. Here we report that disruption of Kruppel-like factor 14 (KLF14) gene mice causes centrosome amplification, aneuploidy and spontaneous tumorigenesis. Molecularly, KLF14 functions as a transcriptional repressor Plk4, polo-like kinase whose overexpression induces overduplication. Transient knockdown sufficient to induce Plk4-directed amplification. Clinically, transcription significantly...
Abstract Sepsis is a heterogeneous syndrome induced by dysregulated host response to infection. Glycolysis plays role in maintaining the immune function of macrophages, which crucial for severely septic patients. However, how pathways that link glycolysis and macrophages are regulated still largely unknown. Here, we provide evidence support KLF14, novel Krüppel-like transcription factor, regulation during sepsis. KLF14 deletion led significantly increased mortality lethal models murine...
Abstract Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells often display centrosome amplification. To maintain survival, achieve bipolar division by clustering supernumerary centrosomes. Targeting is therefore considered a promising therapeutic strategy. However, the regulatory mechanisms of remain unclear. Here we report that KIFC1, regulator, positively associated with recurrence. Under DNA damaging treatments, ATM ATR kinases phosphorylate KIFC1...
Maintenance of energy homeostasis is essential for cell survival. Here, we report that the ATP- and ubiquitin-independent REGγ-proteasome system plays a role in maintaining survival during starvation via repressing rDNA transcription, major intracellular energy-consuming process. Mechanistically, limits cellular transcription consumption by targeting activator SirT7 degradation under normal conditions. Moreover, induces an AMPK-directed phosphorylation subsequent REGγ-dependent subcellular...
Cardiac fibrosis is a primary phenotype of cardiac remodeling that contributes to dysfunction and heart failure. The expansion activation CD4+ T cells in the has been identified facilitate pathological dysfunction; however, underlying mechanisms remained not well clarified. Herein, we found exosomes derived from activated (CD4-activated Exos) evoked pro-fibrotic effects fibroblasts, their delivery into aggravated post-infarction. Mechanistically, miR-142-3p was enriched CD4-activated Exos...
Abstract 5-Fluorouracil (5-FU)-based chemotherapy is the first-line treatment for colorectal cancer (CRC) but hampered by chemoresistance. Despite its impact on patient survival, mechanism underlying chemoresistance against 5-FU remains poorly understood. Here, we identified serine hydroxymethyltransferase-2 (SHMT2) as a critical regulator of in CRC. SHMT2 inhibits autophagy binding cytosolic p53 instead metabolism. prevents degradation inhibiting and HDM2. Under treatment, depletion...
Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer mainly owing to its proclivity early metastasis and lack of effective targeted therapeutic drugs. Hence, understanding molecular mechanisms underlying invasion by PDAC imperative for improving patient outcomes. The present study identified that upregulation TSPAN8 expression in facilitates vivo vitro. We found SOX9 as a key transcriptional regulator response EGF stimulation. modulation was sufficient positively regulate...
SIRT2-mediated deacetylation of SMC1A promotes its phosphorylation and overcomes the oncogenic stress for tumor cell survival.
NAFLD is considered as the hepatic manifestation of metabolic syndrome, which includes insulin resistance, obesity and hyperlipidemia. NASH a progressive stage with severe steatosis, hepatocyte death, inflammation, fibrosis. Currently, no pharmacological interventions specifically tailored for are approved. Ovarian tumor domain, ubiquitin aldehyde binding 1 (OTUB1), founding member deubiquitinases, regulates many metabolism-associated signaling pathways. However, role OTUB1 in unclarified.
phage therapy is a promising approach for infections caused by drug-resistant bacteria; this study evaluated the impact of pre-exposure to particles on subsequent therapy. Mice were exposed intradermally (i.d.) Staphylococcus aureus wide-host-range JD007, member Myoviridae family. phage-specific antibodies detected using ELISA. infected with S. in same way establish dermal abscess model, and then efficacy mice pre-exposed JD007 was evaluated. could induce their specific IgM IgG. levels...
Hypopharyngeal squamous cell carcinoma (HSCC) is a highly aggressive malignancy that constitutes approximately 95% of all hypopharyngeal carcinomas, and it carries poor prognosis. The primary factor influencing the efficacy anti-cancer drugs for this type chemoresistance. Carnitine palmitoyltransferase 1A (CPT1A) has been associated with tumor progression in various cancers, including breast, gastric, lung, prostate cancer. inhibition or depletion CPT1A can lead to apoptosis, curbing cancer...