A5011060859- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Immune Cell Function and Interaction
- Acute Myeloid Leukemia Research
- Cell death mechanisms and regulation
- Chronic Myeloid Leukemia Treatments
- Kruppel-like factors research
- Phagocytosis and Immune Regulation
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Extracellular vesicles in disease
- Retinoids in leukemia and cellular processes
- Childhood Cancer Survivors' Quality of Life
- Calpain Protease Function and Regulation
- RNA Interference and Gene Delivery
Shanghai Jiao Tong University
2025
Shanghai First People's Hospital
2025
Albert Einstein College of Medicine
2019-2022
ORCID
2020
East China Normal University
2013-2016
Baylor College of Medicine
2013
Maintenance of energy homeostasis is essential for cell survival. Here, we report that the ATP- and ubiquitin-independent REGγ-proteasome system plays a role in maintaining survival during starvation via repressing rDNA transcription, major intracellular energy-consuming process. Mechanistically, limits cellular transcription consumption by targeting activator SirT7 degradation under normal conditions. Moreover, induces an AMPK-directed phosphorylation subsequent REGγ-dependent subcellular...
Abstract Autophagy malfunctioning occurs in multiple human disorders, making attractive the idea of chemically modulating it with therapeutic purposes. However, for many types autophagy, a clear understanding tissue-specific differences their activity and regulation is missing because lack methods to monitor these processes vivo. Chaperone-mediated autophagy (CMA) selective type that until now has only been studied vitro not tissue context at single cell resolution. Here, we develop...
Adipogenesis is a tightly orchestrated multistep process wherein preadipocytes differentiate into adipocytes. The most studied aspect of adipogenesis its transcriptional regulation through timely expression and silencing vast number genes. However, whether turnover key regulatory proteins per se controls remains largely understudied. Chaperone-mediated autophagy (CMA) selective form lysosomal protein degradation that, in response to diverse cues, remodels the proteome for purposes. We report...
Abstract Haematopoietic stem cells (HSCs) tightly regulate their quiescence, proliferation, and differentiation to generate blood during the entire lifetime. The mechanisms by which these critical activities are balanced still unclear. Here, we report that Ma crophage- E rythroblast A ttacher (MAEA, also known as EMP), a receptor thus far only identified in erythroblastic island, is membrane-associated E3 ubiquitin ligase subunit essential for HSC maintenance lymphoid potential. Maea highly...
Chaperone-mediated autophagy activity, essential in the cellular defense against proteotoxicity, declines with age, and preventing this decline experimental genetic models has proven beneficial. Here, we have identified mechanism of action selective chaperone-mediated activators previously developed by our group leveraged that information to generate orally bioavailable favorable brain exposure. activating molecules stabilize interaction between retinoic acid receptor alpha - a known...
Human sirtuin1 (SirT1), which is a member of the sirtuin family, plays an important role in wide range cellular processes. Here we demonstrate new strategy for photoelectrochemical assay SirT1 different cell lines based on semiconductor-polymer hybrid system consisting Au-polymer and TiO2-Au nanocomposites. (GC-HBAP) hybrids were synthesized from crosslinked hyperbranched azo-polymer gold colloids then used as immobilization platform antibody. Gold-doped TiO2 (TiO2-Au) nanocomposites...
Abstract Haematopoietic stem cells (HSCs) tightly regulate their quiescence, proliferation, and differentiation to generate blood during the entire lifetime. The mechanisms by which these critical activities are balanced still unclear. Here, we report that Macrophage-Erythroblast Attacher (MAEA, also known as EMP), a receptor thus far only identified in erythroblastic island1, is membrane-associated E3 ubiquitin ligase subunit essential for HSC maintenance lymphoid commitment. Maea highly...