A5042403471- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Venous Thromboembolism Diagnosis and Management
- Genetic Associations and Epidemiology
- Cardiac Ischemia and Reperfusion
- Cancer, Lipids, and Metabolism
- Cardiac Fibrosis and Remodeling
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- Ferroptosis and cancer prognosis
- Heart Failure Treatment and Management
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- IL-33, ST2, and ILC Pathways
- Antiplatelet Therapy and Cardiovascular Diseases
- Peptidase Inhibition and Analysis
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Intelligent Tutoring Systems and Adaptive Learning
- Healthcare and Venom Research
Shanghai Jiao Tong University
2016-2025
Shanghai First People's Hospital
2016-2025
Huazhong University of Science and Technology
2024
Tsinghua University
2024
Yale University
2020
Shanghai Changning Mental Health Center
2008
Chengdu University of Traditional Chinese Medicine
1990
This study investigated whether pretreatment with puerarin could alleviate myocardial ischemia/reperfusion (I/R) injury in a cardiomyocyte oxygen-glucose deprivation and reoxygenation (OGD/R) model mouse I/R model. For vitro experiments, H9C2 cells were divided into control, erastin, OGD/R, OGD/R + puerarin, ferrostatin (Fer)-1 groups. Parameters related to ferroptosis included levels of malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), ATP, reactive oxygen species (ROS), glutathione (GSH),...
Managing recurrent atrial flutter (AFL) following radiofrequency ablation (RFA) for fibrillation (AF) poses significant clinical challenges. We report an 82-year-old male with mirror-image dextrocardia who developed AFL post-AF ablation. During the redo procedure, vein of Marshall ethanol infusion (VOM-Et) was employed as initial intervention, successfully terminating mitral isthmus (MI)-dependent and transitioning into cavotricuspid (CTI)-dependent during infusion. Subsequent restored sinus...
Cardiac fibrosis is a primary phenotype of cardiac remodeling that contributes to dysfunction and heart failure. The expansion activation CD4+ T cells in the has been identified facilitate pathological dysfunction; however, underlying mechanisms remained not well clarified. Herein, we found exosomes derived from activated (CD4-activated Exos) evoked pro-fibrotic effects fibroblasts, their delivery into aggravated post-infarction. Mechanistically, miR-142-3p was enriched CD4-activated Exos...
Aims . We aimed to investigate whether LCZ696 protects against pathological cardiac hypertrophy by regulating the Sirt3/MnSOD pathway. Methods In vivo , we established a transverse aortic constriction animal model establish pressure overload-induced heart failure. Subsequently, mice were given oral gavage for 4 weeks. After that, underwent transthoracic echocardiography before they sacrificed. vitro introduced phenylephrine prime neonatal rat cardiomyocytes and small-interfering RNA knock...
Atrial fibrosis serves as an important contributor to atrial fibrillation (AF). Recent data have suggested that microRNA-30c (miR-30c) is involved in fibrotic remodelling and cancer development, but the specific role of miR-30c remains unclear. The purpose this study was investigate its underlying mechanisms through vivo vitro experiments. Our results indicate significantly down-regulated rat abdominal aortic constriction (AAC) model cellular induced by transforming growth factor-β1...
Emerging evidences indicate that SCN10A/NaV1.8 is associated with cardiac conduction and atrial fibrillation, but the exact role of NaV1.8 in electrophysiology remains poorly understood. The present study was designed to investigate effects blocking channels ganglionated plexi (GP) on modulating fibrillation inducibility canine model.Thirteen mongrel dogs were randomly enrolled. Right cervical vagus nerve stimulation (VNS) applied determine its sinus rate, ventricular rate during PR...
The present study aimed to evaluate the importance of cyanidin 3-glucoside (C3G) diabetic cardiomyopathy in rats. rats were induced with using streptozotocin and total triglyceride (TG) cholesterol (TC) determined. range myocardial enzymes such as aspartate aminotransferase (AST), creatine kinase (CK) lactate dehydrogenase (LD) also estimated, further, Immuno histochemical analysis western blot investigation determined for actual activity C3G. Results indicated that marker CK, LD AST...
Premature ventricular complex (PVC) with narrow QRS duration originating from proximal left anterior fascicle (LAF) is challenging for ablation. This study was performed to evaluate the safety and feasibility of ablation right coronary cusp (RCC) LAF-PVC investigate this PVC's characteristics.Mapping at RCC ventricle ECG analysis were in 20 patients LAF-PVC.The earliest activation site (EAS), Purkinje potential during both PVC sinus rhythm, localized LAF 8 (proximal group) nonproximal 12...
Crosstalk between fibroblasts and cardiomyocytes (CMs) plays a critical role in cardiac remodelling during heart failure (HF); however, the underlying molecular mechanisms remain obscure. Recently, secretory protein, Integrin beta-like 1 (ITGBL1) was revealed to have detrimental effects on several diseases, such as tumours, pulmonary fibrosis, hepatic fibrosis; whereas effect of ITGBL1 HF is unclear. The purpose this study evaluate its contribution volume overload-induced remodelling.In...
Mitral isthmus (MI) ablation is challenging. We hoped to close those conduction breakthrough sites (CBS) across the MI by elaborate mapping.After initial linear ablation, elaborately mapping large areas above and below line inside coronary sinus (CS) was sequentially performed identify CBS. The shortest distance from CBS measured. distant (D-CBS) identified as >5.0 mm away line. prospectively enrolled 177 consecutive patients. Bidirectional blockage obtained in 50 (28.2%) patients after...
Visuomotor imitation learning enables embodied agents to effectively acquire manipulation skills from video demonstrations and robot proprioception. However, as scene complexity visual distractions increase, existing methods that perform well in simple scenes tend degrade performance. To address this challenge, we introduce Imit Diff, a semanstic guided diffusion transformer with dual resolution fusion for learning. Our approach leverages prior knowledge vision language foundation models...
The influence of procedural arrhythmia termination on long-term single-procedure clinical outcome in patients with non-paroxysmal atrial fibrillation (AF) remains controversial.An individualized stepwise ablation strategy was used 200 consecutive AF who underwent first-time radiofrequency catheter ablation, pulmonary vein isolation and sinus rhythm (SR) restoration as the primary endpoints.SR restored by 94 patients, including 32 directly 62 intermediate tachycardia (AT). Cardioversion...
Background: Positive associations between inflammatory biomarkers and the risk of heart failure (HF) have been reported in conventional observational studies. However, causal effects on HF not fully elucidated. We conducted a Mendelian randomization (MR) study to examine possible etiological roles HF. Methods: Summary statistical data for single nucleotide polymorphisms (SNPs) C-reactive protein (CRP), fibrinogen, components interleukin-1 (IL-1)-interleukin-6 (IL-6) signaling pathway,...
Abstract The prevalence and antithrombotic treatment of atrial fibrillation (AF) in Chinese rural population is not well known. aim this study was to investigate the extent which prescribed for AF patients >60 years. We identified 828 from 36734 residents years Shanghai China. Our data indicated overall rate 2.3% East China 38.9% underwent therapy, including warfarin (5.9%), aspirin (29.6%), clopidogrel (2.9%) combined with (0.5%). Of enrolled subjects, 98.4% had CHA 2 DS -VASc score ≥1,...
China bears the biggest atrial fibrillation (AF) burden in world. However, little is known about incidence and predictors of AF. This study aimed to investigate current AF its electrocardiographic (ECG) general community individuals aged over 60 years China.This was a prospective cohort study, recruiting subjects who were underwent annual health checkups from April July 2015 four centers Songjiang District, Shanghai, China. The then followed up 2019 annually. Data on sociodemographic...
Abstract Abnormal cardiac fibrosis is the main pathological change of post-myocardial infarction (MI) heart failure. Although E3 ubiquitin ligase FBXL8 a key regulator in cell cycle, proliferation, and inflammation, its role post-MI ventricular failure remains unknown. was primarily expressed fibroblasts (CFs) remarkably decreased CFs treated by TGFβ subjected to MI. The echocardiography histology data suggested that adeno-associated viruses (AAV9)-mediated overexpression had improved...
Renal denervation (RD) was reported to reduce the susceptibility of atrial fibrillation (AF), but underlying mechanism has not been well understood. This study performed investigate effect RD on inducibility AF in a rabbit model for fibrosis and explore potential mechanisms. Thirty-five rabbits were randomly assigned into sham-operated group (n = 12), abdominal aortic constriction (AAC) 12) AAC with (AAC-RD) 11). The incidence induced by burst pacing atriums determined. Blood collected...