A5000814048- Neuroscience and Neuropharmacology Research
- Mesenchymal stem cell research
- Reconstructive Facial Surgery Techniques
- Nanoparticle-Based Drug Delivery
- Immune Response and Inflammation
- Reconstructive Surgery and Microvascular Techniques
- High Altitude and Hypoxia
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Cancer and Skin Lesions
- Inflammasome and immune disorders
- Extracellular vesicles in disease
- Facial Rejuvenation and Surgery Techniques
- Peanut Plant Research Studies
- Ear Surgery and Otitis Media
- Ion channel regulation and function
- Nerve injury and regeneration
- Traumatic Brain Injury and Neurovascular Disturbances
- Coconut Research and Applications
- Thermal Regulation in Medicine
- Facial Nerve Paralysis Treatment and Research
- Periodontal Regeneration and Treatments
- Traditional Chinese Medicine Studies
- Digital Imaging in Medicine
- Wound Healing and Treatments
Guangzhou Medical University
2025
Shandong Academy of Agricultural Sciences
2022
National Institute of Biological Sciences, Beijing
2021-2022
Beijing Normal University
2022
Chinese People's Liberation Army
2012-2020
Lanzhou Army General Hospital
2005-2020
Institute of Applied Ecology
2019
Chinese Academy of Sciences
2001-2019
Xiangya Hospital Central South University
2017-2018
Central South University
2017-2018
Centrosome amplification is frequent in cancer, but the underlying mechanisms remain unclear. Here we report that disruption of Kruppel-like factor 14 (KLF14) gene mice causes centrosome amplification, aneuploidy and spontaneous tumorigenesis. Molecularly, KLF14 functions as a transcriptional repressor Plk4, polo-like kinase whose overexpression induces overduplication. Transient knockdown sufficient to induce Plk4-directed amplification. Clinically, transcription significantly...
Stearoyl lysophosphatidylcholine (LPC) exerts protective effect during endotoxemia and in experimental sepsis, but the underlying mechanism is unclear. Here, we demonstrated that stearoyl LPC could block caspase-11-mediated macrophage pyroptosis. In vitro, significantly decreased caspase-11 activation pyroptosis induced by lipopolysaccharide (LPS) plus cholera toxin subunit B independent of receptor G2A. did not affect LPS uptake mouse peritoneal macrophages inhibit interaction between...
Lung adenocarcinoma (LUAD) is a major subtype of lung cancer and one the deadliest cancers in humans. Dysregulation miRNA activity tumor-associated neutrophils (TANs) tumor microenvironment plays an important role occurrence development LUAD. In this study, miReact algorithm was used to analyze single-cell RNA sequencing data LUAD samples reveal profile characteristics TANs patients. The function miR-941 investigated vivo vitro. target gene underlying signaling pathway were predicted...
The objective of this study was to investigate the pharmacokinetics and in vivo anti-tumor effect recombinant human tumor necrosis factor-α (rHuTNF-α) encapsulated poly(methoxypolyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate) (PEG-PHDCA) nanoparticles. Our experimental results showed that PEG-PHDCA nanoparticles could extend half-life rHuTNF-α 7.42 h obviously change protein biodistribution tissues, particular, increase accumulation tumor. Compared with PHDCA free rHuTNF-α,...
<b><i>Background:</i></b> Basic fibroblast growth factor (bFGF) has been increasingly investigated due to its neuroprotection in neurodegenerative disorders. Because there are still no cures for any of these disorders, it is crucial identify new therapeutic targets and screen potential drugs. The increased phosphorylation tau at Ser<sup>396</sup> leads intracellular accumulation, which forms neurofibrillary tangles Parkinson's disease (PD). In this study,...
Peanut is one of the most important cash crops with high quality oil, protein content, and many other nutritional elements, grown globally. Cultivated peanut (Arachis hypogaea L.) allotetraploid a narrow genetic base, its genetics molecular mechanisms controlling agronomic traits are poorly understood. Here, we report comprehensive genome variation map based on genotyping panel 178 cultivars using Axiom_Arachis2 SNP array, including 163 representative varieties different provinces in China,...
Mesenchymal stem cells (MSCs) can be isolated from numerous tissues and have the potential for self-renewal multidirectional differentiation. Evidence is accumulating which suggests that MSCs are also present in gingival tissue. This study aimed to evaluate feasibility of collecting, purifying, amplifying gingival-derived (GMSCs) canine gingiva obtain GMSC-derived exosomes (GMSC-exo). GMSCs were cultured; furthermore, cellular immunofluorescence demonstrated possess characteristic MSC...
The monotypic genus Leifia was previously considered to be a later synonym of Odonticium. With the morphological and phylogenetic evidence provided by an additional four East Asian specimens, we propose reinstate as independent in Hymenochaetales. morphologically differs from Odonticium its grandinioid hymenophore with hyphal strands, numerous thick-walled cystidia invaginated apical end narrowly basidia. phylogeny generated current data set ITS 28S regions indicates that forms sister clade...
The purpose of this study was to preliminarily assess a constant pressure and quantity fat granule injection device for minimal invasive properties in clinic. A retrospective controlled carried out, from October 2013 January 2015, on 76 female healthy patients aged between 26 53 years at the General Hospital Lanzhou Military Command, China. To achieve small volume, high thrust, precision requirements facial grafting, an integrated handheld controller motor design adopted, reducing volume...
Congenital enlargement of one or several digits the foot, known as macrodactyly, is a rare malformation. Macrodactyly impedes foot development and affects function gait. Here, we describe surgical technique used to correct macrodactyly in two pediatric patients. We performed amputation enlarged phalanx debulking soft tissues construct normal-sized digit. This precise involves simple plan that preserves metatarsus cuneiform does not result wide plantapedis. Both patients subsequently showed...
The aim of the present work was to investigate and assess merit PEGylated recombinant human tumor necrosis factor-α (rHuTNF-α) following our previous work. rHuTNF-α modified using activated polyethylene glycol (PEG), N-succinimidyl succinnate monomethoxy (SS-PEG). pharmacokinetics anti-tumor effect were investigated. experimental results showed that could obviously alter in vivo behavioral characteristics rHuTNF-α. Among synthesized PEG-rHuTNF-αs with different PEG molecules,...