A5011071284- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- RNA Research and Splicing
- Circular RNAs in diseases
- Caveolin-1 and cellular processes
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Pediatric Urology and Nephrology Studies
- Kidney Stones and Urolithiasis Treatments
- Metabolism, Diabetes, and Cancer
- Cellular Mechanics and Interactions
- Phytoestrogen effects and research
- Bladder and Urothelial Cancer Treatments
- Urological Disorders and Treatments
- Cancer, Hypoxia, and Metabolism
- Visual perception and processing mechanisms
- Pancreatic function and diabetes
- Urinary Bladder and Prostate Research
- Diabetes Treatment and Management
- Minimally Invasive Surgical Techniques
- Nitric Oxide and Endothelin Effects
- Prostate Cancer Treatment and Research
- Ion Transport and Channel Regulation
Guangzhou Medical University
2017-2025
Wenzhou Medical University
2024-2025
University of Chinese Academy of Sciences
2025
Third Affiliated Hospital of Guangzhou Medical University
2021-2023
Lund Science (Sweden)
2019-2020
Lund University
2017-2018
Taiyuan University of Technology
2018
Biomechanics Institute of Valencia
2018
Air Force Medical University
2007-2015
Sun Yat-sen University
2010-2013
The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has become a global pandemic, but the factors influencing viral RNA shedding, which would help inform optimal control strategies, remain unclear.
Abstract Compelling evidence indicates that stress in utero, as manifested by low birth weight (LBW), increases the risk of metabolic syndrome adulthood. Singletons conceived assisted reproductive technology (ART) display a significant increase LBW and ART offspring have different profile starting at birth. Here, used mouse model, we found resulted reduced fetal placental overgrowth embryonic day 18.5 (E18.5). The placentae exhibited histomorphological alterations with defects layer...
Both lncRNAs and the N6-methyladenosine (m6A) modification are key regulators of tumorigenesis innate immunity. However, little is known about m6A their clinical immune relevance in bladder cancer. In this study, we identified m6A-related using Pearson correlation analysis The Cancer Genome Atlas (TCGA) IMvigor210 datasets. Next, univariate Cox regression was performed TCGA dataset to filter prognostic lncRNAs, which were further subjected least absolute shrinkage selection operator (LASSO)...
Abstract Hypertension is a dominating risk factor for cardiovascular disease. To characterize the genomic response to hypertension, we administered vehicle or angiotensin II mice and performed gene expression analyses. AngII treatment resulted in robust increase blood pressure altered of 235 genes aorta, including Gucy1a3 Gucy1b3 which encode subunits soluble guanylyl cyclase (sGC). Western blotting immunohistochemistry confirmed repression sGC associated with curtailed relaxation via...
MicroRNAs (miRNAs) are closely associated with cell proliferation, invasion and metastasis in various types of cancer, including prostate cancer. In this study, the role miR-429 regulation proliferation was investigated cancer cells. expression levels were measured IF11 IA8 lines normal epithelial tissues by quantitative polymerase chain reaction. mimics or an inhibitor then transfected into human lines. MTT fluorescence-activated sorting used to detect effect on proliferation. A luciferase...
Abstract Background The novel coronavirus disease 2019 (COVID-19) characterized by respiratory symptoms has become a global pandemic although factors influencing viral RNA clearance remained unclear to inform optimal isolation period and treatment strategies. Methods In this retrospective study, we included patients with confirmed COVID-19 admitted Guangzhou Eighth People’s Hospital from 20 th January 2020 15 March 2020. associations of clinical characteristics regimens on time were...
Abstract Background Prostate cancer (PCa) is one of the most common malignancies in men. YTHDF1 may play an important role promoting PCa progression, but there no reports to date on function PCa. Objective This study explored whether could regulate TRIM44 cells. Methods By querying TCGA database, we evaluated expression PCa, OS and DFS YTHDF1, correlation between We constructed vectors interfere with overexpress examine Differentially expressed mRNAs were identified by mRNA sequencing. The...
One of the most remarkable human cognitive abilities is “sense number,” that is, almost instantaneous perception numerosity information in visual environment. While mirrors primary sensory processing many aspects, little known whether and how influenced by selective attention to numerosity. Here, we investigated effects feature-based on using search paradigm adaptation paradigm, respectively. In experiment, participants identified presence a numerosity-defined outlier among an array...
Lung adenocarcinoma (LUAD) is a major subtype of lung cancer and one the deadliest cancers in humans. Dysregulation miRNA activity tumor-associated neutrophils (TANs) tumor microenvironment plays an important role occurrence development LUAD. In this study, miReact algorithm was used to analyze single-cell RNA sequencing data LUAD samples reveal profile characteristics TANs patients. The function miR-941 investigated vivo vitro. target gene underlying signaling pathway were predicted...
Nexilin, encoded by the NEXN gene, is expressed in striated muscle and localizes to Z-discs, influencing mechanical stability. We examined Nexilin/NEXN smooth cells (SMCs), addressed if Nexilin dense bodies bands whether it regulated actin-controlled coactivators from MRTF (MYOCD, MKL1, MKL2) YAP/TAZ (YAP1 WWTR1) families. expression SMCs was comparable that muscles. Immunofluorescence immunoelectron microscopy suggested bands. Correlations at mRNA level might be controlled actin...
Abstract Background Oncogenic metabolic reprogramming contributes to tumor growth and immune evasion. The intertumoral heterogeneity interaction of distinct pathways may determine patient outcomes. In this study, we aim the clinical immunological significance subtypes according expression levels genes related glycolysis cholesterol-synthesis in bladder cancer (BCa). Methods Based on median glycolytic cholesterogenic genes, patients were stratified into 4 (mixed, cholesterogenic, glycolytic,...
Myocardin (MYOCD) is a critical regulator of smooth muscle cell (SMC) differentiation, but its transcriptional targets remain to be exhaustively characterized, especially at the protein level. Here we leveraged human RNA and expression data identify novel potential MYOCD targets. Using correlation analyses found several that could confirm level, including SORBS1, SLMAP, SYNM, MCAM. We focused on which encodes intermediate filament synemin. SYNM rivalled myosin (MYH11) for SMC specificity was...
Excess intracellular reactive oxygen species (ROS) beyond a threshold can induce apoptosis in cancer cells. However, the signal pathways that augment proapoptotic function of ROS remain largely unknown. We previously identified tumor suppressor, alpha-tocopherol-associated protein (TAP), yet little is known regarding role TAP apoptotic signaling prostate cancer. Interestingly, we recently found exposure cells to hydrogen peroxide (H(2)O(2) ) resulted induced as well increased expression TAP....
Abstract Smooth muscle cells (SMCs) are characterized by a high degree of phenotypic plasticity. Contractile differentiation is governed myocardin‐related transcription factors (MRTFs), in particular myocardin (MYOCD), and when their drive lost, the become proliferative synthetic with an expanded endoplasmic reticulum (ER). ER responsible for assembly folding secreted proteins. When load on surpasses its capacity, three stress sensors (activating factor 6 [ATF6], inositol‐requiring enzyme 1α...
Background and Purpose: Laparoendoscopic single-site (LESS) surgery through the retroperitoneal approach has been seldom reported. We aimed to compare feasibility outcomes of LESS conventional laparoscopic via in management large, impacted ureteral stones. Patients Methods: From June 2010 May 2011, ureterolithotomy was performed 10 patients (the group). Another 15 who underwent group) by same surgeon were involved compared. The operative time, complications, surgical evaluated. Results: All...
Cavins belong to a family of proteins that contribute the formation caveolae, which are membrane organelles with functional roles in muscle and fat. Here, we investigate effect cavin-3 ablation on vascular urinary bladder structure function. Arteries bladders from mice lacking (knockout: KO) controls (wild type: WT) were examined. Our studies revealed loss resulted ∼40% reduction caveolae protein cavin-1 smooth muscle. Electron microscopy demonstrated was accompanied by abundance 40-45%...
The purpose of this study was to develop and test a method for measuring pressure in the upper urinary tract during ureteroscopic operations evaluate its efficacy clinical significance.A total 44 patients, each with ureteral calculus proximal segment, were enrolled group: 21 patients an acute 23 chronic obstruction. ureteroscope passed forward segment obstructed ureter immediately after broken intraluminal then transmitted along irrigant flow (0.9% sodium chloride).The mean pressures...