A5053985564- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Luminescence and Fluorescent Materials
- Polymer Surface Interaction Studies
- Dendrimers and Hyperbranched Polymers
- Photoacoustic and Ultrasonic Imaging
- Perovskite Materials and Applications
- Lanthanide and Transition Metal Complexes
- Gold and Silver Nanoparticles Synthesis and Applications
- Sulfur Compounds in Biology
- Luminescence Properties of Advanced Materials
- Advanced Polymer Synthesis and Characterization
- ZnO doping and properties
- Surgical Sutures and Adhesives
- Mesoporous Materials and Catalysis
- 2D Materials and Applications
- Supramolecular Chemistry and Complexes
- Graphene and Nanomaterials Applications
- MRI in cancer diagnosis
- Hydrogels: synthesis, properties, applications
- Advanced Photocatalysis Techniques
- Characterization and Applications of Magnetic Nanoparticles
- Advanced biosensing and bioanalysis techniques
- Transition Metal Oxide Nanomaterials
- Inorganic Chemistry and Materials
Nanjing University
2017-2025
Dalian Minzu University
2022-2025
State Council of the People's Republic of China
2019
Ningbo Institute of Industrial Technology
2015-2016
Chinese Academy of Sciences
2014-2016
Ningbo University
2015
ABSTRACT Compared to fluorescence imaging, chemiluminescence imaging does not need external excitation light, and hence presents high depth signal‐to‐noise ratio without autofluorescence phototoxicity, making it a promising tool for biological detection analysis. However, the target‐specific activatable near‐infrared emission chemiluminescent probes still be developed precise diagnosis of diseases. In this paper, we synthesized four direct Schaap's chemiluminophores (AINCL, AIFCL, ABTCL,...
The detection of circulating tumor cells (CTCs) in the blood cancer patients is crucial for early diagnosis, prognosis, evaluation treatment effect chemotherapy drugs, and choice options. In this study, we propose new surface-enhanced Raman scattering (SERS) nanoparticles direct CTCs blood. Under optimized experimental conditions, our SERS exhibit satisfying performances rabbit A good linear relationship obtained between intensity concentration range 5–500 cells/mL (R2 = 0.9935), which...
Magnetic resonance imaging (MRI), a sophisticated promising three-dimensional tomographic noninvasive diagnostic technique, has an intrinsic advantage in safety compared with radiotracer and optical modalities; however, MRI contrast agents are less sensitive than complexes used other techniques. Usually the clinically Gd-based MRI-T1 toxic; therefore, demand for nontoxic novel T1-weighted candidates ultrasensitive advanced functionality is very high. In this research, silica-coated...
Abstract Creation of new fluorophores is important for understanding the structure–property relationship, by which required optical properties are likely to be attained. Herein, through theory calculation, it found that furan‐modified thiadiazolo quinoxaline acting as an electron acceptor can endow donor–acceptor–donor (D–A–D) type second near‐infrared (NIR‐II) with longer emission wavelength than other quinoxaline‐based acceptors containing pyridine, pyrrole, thiophene, and phenyl groups,...
Layered bismuth oxyhalide nanomaterials have received much more interest as promising photocatalysts because of their unique layered structures and high photocatalytic performance, which can be used potential inorganic photosensitizers in tumor photodynamic therapy (PDT). In recent years, materials been widely PDT photothermal (PTT) photosensitizers. This investigation focuses on applying toward cancer PDT, an application that has never reported so far. The results our study indicate the...
Understanding structure-fluorescence correlation is very helpful for the design of fluorescent probes. In this paper, a donor-acceptor-donor (D-A-D) type NIR-II fluorophore with benzobisthiadiazole as acceptor and triphenyl amine donor, its three derivatives bearing respectively amino, tert-butyloxycarbonyl amino phenylazo groups in donor moieties, are synthesized. Their electronic structures optical properties investigated via theoretical experimental studies. It found that all types...
Multidrug resistance (MDR) of cancers is still a major challenge, and it very important to develop visualized nanoprobes for the diagnosis treatment drug resistant cancers. In this work, we developed multifunctional delivery system based on DOX-encapsulated NaYF4:Yb/Er@NaGdF4 yolk-shell nanostructures simultaneous dual-modal imaging enhanced chemotherapy in breast cancer. Using large pore volume nanostructure, had high loading efficiency excellent stability. Also, an vitro vivo toxicity...
Cylindrical polymer brushes with different lengths were synthesized and length effects on their biological properties obtained.
To enhance the water solubility of α-cyclodextrin (CD) polyrotaxanes (PRs) and achieve effective drug loading, we polymerized 2-hydroxyethyl methacrylate 2-tert-butoxy-N-(2-(methacryloyloxy)ethyl)-N,N-dimethyl-2-oxoethanaminium successively from a α-CD-PR-based macroinitiator by two-step ATRP followed cleaving tert-butyl ester groups, providing α-CD-PR-cored multiarm copolymer. The copolymer had reactive hydroxyl pendant groups in inner block arms, which were used to incorporate antitumor...
Although many types of second near-infrared (NIR-II) dyes have been developed, the NIR-II dye bearing a single reactive group, which is indispensable for specifically labeling nanomaterials or biofunctional molecules, still lacking. In this work, donor–acceptor–donor type named IR1032 an amino group was synthesized and used to covalently label cylindrical polymer brushes. The labeled brushes (named brushes1032) had densely grafted poly(ethylene glycol) (PEG) chains exhibited wormlike...
Abstract Specifically amplifying the emission signals of optical probes in tumors is an effective way to improve tumor‐imaging sensitivity and contrast. In this paper, first case dendron‐based fluorescence turn‐on mediated by a Förster resonance energy transfer (FRET) mechanism reported. Dendrons up fourth generation with hydrophilic oligo(ethylene glycol) scaffold are synthesized solid‐phase synthesis strategy, show precise defect‐free chemical structures. To construct probe, one Cy5.5...
Size is one of the crucial factors influencing biological properties nanomedicines. However, size control nanomaterials still very challenging, and effect on their worth studying. Herein, we present synthesis a series multiarm block copolymers with third-generation PAMAM (G3 PAMAM) as core. The were synthesized by ring-opening polymerization N-carboxyanhydride l-glutamic acid-5-tert-butylester [Glu(OtBu)-NCA] monomer amine-terminated initiator, followed poly(carboxybetaine) (PCB) via atom...
Fluorination has been widely applied to improving the properties of small-molecule drugs. However, relatively little is known about effects fluorination on drug delivery property nanomaterials. In this paper, we synthesized a fluoroalkane-modified cylindrical polymer brush (CPB) BCPB-F and an alkane-modified analogue BCPB-H. Doxorubicin (DOX) was used as model loaded onto CPBs through pH-responsive acylhydrazone linkage. High loading good water solubility were achieved. The in vitro vivo...
Correction for 'Layered bismuth oxyhalide nanomaterials highly efficient tumor photodynamic therapy' by Yu Xu, et al., Nanoscale, 2016, DOI: 10.1039/c5nr04540a.