A5100442625- Nanoplatforms for cancer theranostics
- Immune Response and Inflammation
- Nanoparticle-Based Drug Delivery
- Urinary Bladder and Prostate Research
- Neurological Disease Mechanisms and Treatments
- Cancer Immunotherapy and Biomarkers
- S100 Proteins and Annexins
- Geological and Geophysical Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Catalytic C–H Functionalization Methods
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Advanced biosensing and bioanalysis techniques
- Cytokine Signaling Pathways and Interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Immune Cell Function and Interaction
- Pelvic floor disorders treatments
- Anesthesia and Pain Management
- Peptidase Inhibition and Analysis
- Immunotherapy and Immune Responses
- Protease and Inhibitor Mechanisms
- Immune cells in cancer
University of Pittsburgh
2017-2025
Sichuan University
2019-2025
Sun Yat-sen University
2014-2025
Zhejiang Provincial People's Hospital
2019-2024
Women's Hospital, School of Medicine, Zhejiang University
2024
Hangzhou Medical College
2023-2024
Beijing Friendship Hospital
2024
Capital Medical University
2024
VA Pittsburgh Healthcare System
2023-2024
Geriatric Research Education and Clinical Center
2023-2024
Abstract Immune system molecules are expressed by neurons, yet their functions often unknown. We have identified IL-13 and its receptor IL-13Ra1 as neuronal, synaptic proteins in mouse, rat, human brains, whose engagement upregulates the phosphorylation of NMDAR AMPAR subunits and, turn, increases activity CREB-mediated transcription. demonstrate that increased is a hallmark traumatic brain injury (TBI) male mice well two distinct cohorts patients. also provide evidence upregulation protects...
Therapeutic approaches of combining conventional photodynamic therapy (PDT) with other adjuvant treatments to sensitize PDT represent an appealing strategy. Herein, a novel synergetic "nanobomb" strategy based on glutathione (GSH)-responsive biodegradation was proposed effectively destroy tumors expeditiously and accurately. This rationally constructed via the simultaneous encapsulation methylene blue (MB) l-arginine (L-Arg) into polyethylene glycol (PEG) modified mesoporous organosilicon...
Cancer diagnosis and treatment represent an urgent medical need given the rising cancer incidence over past few decades. theranostics, namely, combination of diagnostics therapeutics within a single agent, are being developed using various anticancer drug-, siRNA-, or inorganic materials-loaded nanocarriers. Herein, we demonstrate strategy encapsulating quantum dots, superparamagnetic Fe3O4 nanocrystals, doxorubicin (DOX) into biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) polymeric...
The long-term associations between dietary copper (Cu) and selenium (Se) intakes type 2 diabetes mellitus (T2DM) risk are unclear. We aimed to examine the prospective Cu Se T2DM in Chinese adults. A total of 14,711 adults from China Health Nutrition Survey (1997-2015) were included. Nutrient assessed by 3 consecutive 24 h recalls food-weighing methods. was identified a validated questionnaire laboratory examination. Cox regression models used for statistical analysis. 1040 cases diagnosed...
The use of low‐intensity pulsed ultrasound (LIPUS) for promoting fracture healing has been Food and Drug Administration (FDA)‐approved since 1994 due to largely its non‐thermal effects sound flow radiation force so on. Numerous clinical animal studies have shown that LIPUS can accelerate the fresh fractures, nonunions, delayed unions in pulse mode regardless devices or circumstantial factors. Rare show limitations treating fractures with intramedullary nail fixation low patient compliance....
We are extending the Cre/loxP site-specific recombination system to pigs, focussing on conditional and tissue-specific expression of oncogenic mutations model human cancers. Identifying location, pattern extent Cre in vivo is an important aspect this technology. Here we report pigs with a dual fluorochrome cassette under control strong CAG promoter that switches after Cre-recombination, from membrane-targeted tandem dimer Tomato green fluorescent protein. The reporter was placed at porcine...
Nanomedicine enabled cancer combination immunotherapy not only sufficiently activates the host immune system, but also reprograms immunosuppressive microenvironment, representing a new generation approach to treat cancer. Herein, we demonstrated targeted photo- and immune-active nanoplatform termed NLG919@HA-Ce6 simultaneously elicit efficient immunogenic cell death (ICD) using photosensitizer Ce6 modulate tryptophan metabolic pathway an indoleamine 2,3-dioxygenase (IDO) inhibitor NLG919 for...
Sepsis, a life-threatening condition whereby immune dysregulation develops, is one of the major causes death worldwide. To date, there still no clinically effective therapeutic method for sepsis. As natural product from traditional Chinese medicine, Shikonin has been demonstrated to have pleiotropic medical effects, including anti-tumor, anti-inflammation, and relieving PD-L1, as receptor PD-1, was also involved in exacerbating sepsis by inducing immunosuppression, but relationship between...
Cancer immunotherapy is a treatment method that activates or enhances the autoimmune response of body to fight tumor growth and metastasis, has fewer toxic side effects longer-lasting efficacy than radiotherapy chemotherapy, become an important means for clinical cancer. However, results from have shown most patients lack responsiveness cannot benefit this strategy. The microenvironment (TME) plays critical role in immunotherapy. TME typically prevents effective lymphocyte activation,...
The diffuse axonal damage in white matter and neuronal loss, along with excessive neuroinflammation, hinder long-term functional recovery after traumatic brain injury (TBI). MicroRNAs (miRs) are small noncoding RNAs that negatively regulate protein-coding target genes a posttranscriptional manner. Recent studies have shown loss of function the miR-15a/16-1 cluster reduced neurovascular improved ischemic stroke vascular dementia. However, role neurotrauma is poorly explored. Here, we report...