A5115589969- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune Response and Inflammation
- Sphingolipid Metabolism and Signaling
- Advanced Glycation End Products research
- Immune cells in cancer
- S100 Proteins and Annexins
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cytokine Signaling Pathways and Interactions
- RNA modifications and cancer
- Cardiac Ischemia and Reperfusion
- Tryptophan and brain disorders
- Advanced Algorithms and Applications
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Growth Hormone and Insulin-like Growth Factors
- Endoplasmic Reticulum Stress and Disease
- Gut microbiota and health
- Reproductive System and Pregnancy
- Complement system in diseases
- Signaling Pathways in Disease
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
Beihua University
2024-2025
Tianjin Huanhu Hospital
2025
Tianjin Medical University
2025
Nanjing Medical University
2024
Shangdong Agriculture and Engineering University
2024
Shanxi Medical University
2010-2024
First Hospital of Shanxi Medical University
2010-2024
University of Saskatchewan
2014-2024
Dalian Institute of Chemical Physics
2024
Chinese Academy of Sciences
2024
Abstract Inflammatory depression is a treatment-resistant subtype of depression. A causal role the gut microbiota as source low-grade inflammation remains unclear. Here, part an observational trial, we first analyze composition in stool, inflammatory factors and short-chain fatty acids (SCFAs) plasma, permeability markers intestinal mucosa patients with (ChiCTR1900025175). Gut exhibits higher Bacteroides lower Clostridium , increase SCFA-producing species abnormal butanoate metabolism. We...
Abstract Lymphocyte CD44 interactions with hyaluronan localized on the endothelium have been demonstrated to mediate rolling and regulate lymphocyte entry into sites of chronic inflammation. Because neutrophils also express CD44, we investigated role in multistep process neutrophil recruitment. CD44−/− wild-type control mice were intrascrotally injected neutrophil-activating chemokine, MIP-2, leukocyte kinetics cremasteric microcirculation 4 h subsequently using intravital microscopy....
The complement system is becoming increasingly recognized as a key participant in many neurodegenerative diseases of the brain. Complement-deficient animals exhibit reduced neuroinflammation.In present study, we administered intracerebroventricularly lipopolysaccharide (LPS) to mimic local infection brain and investigated role component C3 vasculature endothelial activation leukocyte recruitment. degree neutrophil infiltration was determined by esterase staining. Leukocyte-endothelial...
Interleukin-33 (IL-33) is increasingly being recognized as a key immunomodulatory cytokine in many neurological diseases.In the present study, wild-type (WT) and IL-33-/- mice received intracerebroventricular (i.c.v.) injection of lipopolysaccharide (LPS) to induce neuroinflammation. Intravital microscopy was employed examine leukocyte-endothelial interactions brain vasculature. The degree neutrophil infiltration determined by myeloperoxidase (MPO) staining. Real-time PCR western blotting...
TGF-β is a key profibrotic factor, but targeting to prevent fibrosis also abolishes its protective anti-inflammatory effects. Here, we investigated the hypothesis that can redirect signaling by preventing downstream interaction of β-catenin with T cell factor (TCF), thereby enhancing Foxo, transcription controls differentiation induced regulatory cells (iTregs), and thus, enhance effects In iTregs derived from EL4 treated recombinant human TGF-β1 (rhTGF-β1) in vitro, inhibition β-catenin/TCF...
A kochia biotype from McDonough County, Illinois, was suspected to be resistant both triazine and acetolactate synthase (ALS)-inhibiting herbicides. We performed greenhouse laboratory experiments confirm, quantify, determine the molecular basis of multiple herbicide resistance in this biotype. Whole-plant phytotoxicity assays confirmed that (atrazine), imidazolinone (imazethapyr), sulfonylurea (thifensulfuron chlorsulfuron) Relative a susceptible biotype, these herbicides ranged 500- >...
Methylglyoxal (MG) is a reactive dicarbonyl metabolite formed during glucose, protein and fatty acid metabolism. In hyperglycaemic conditions, increased MG level has been linked to the development of diabetes its vascular complications at macrovascular microvascular levels where inflammation plays role. To study mechanism MG-induced in vivo, we applied locally healthy mice used intravital microscopy investigate role endothelial cell adhesion molecules leucocyte recruitment cremasteric...
Abstract Background Insulin resistance is strongly associated with the development of type 2 diabetes and cardiovascular disease. However, underlying mechanisms linking insulin atherosclerosis have not been fully elucidated. Moreover, protective effect antihyperglycemic agent, metformin, understood. This study investigated effects metformin in balloon-injury induced stenosis resistant rats. Methods After 4 weeks high fructose diet, rats received balloon catheter injury on carotid arteries...
The non-receptor tyrosine kinase SRC is a key mediator of cellular protumorigenic signals. aberrantly over-expressed and activated in more than 80% colorectal cancer (CRC) patients, therefore regulation its stability activity essential. Here, we report significant down SNX10 (sorting nexin 10) human CRC tissues, which closely related to tumor differentiation, TNM stage, lymph node metastasis survival period. deficiency normal neoplastic epithelial cells promotes initiation progression mice....
SNX10 (sorting nexin 10) has been reported to play a critical role in regulating macrophage function and lipid metabolism.To investigate the precise of atherosclerotic diseases underlying mechanisms.SNX10 expression was compared between human healthy vessels carotid plaques. Myeloid cell-specific knockdown mice were crossed onto APOE-/- (apolipoprotein E) background atherogenesis (high-cholesterol diet-induced) monitored for 16 weeks. We found that increased lesions aortic specimens from...
Our previous study found that insulin-like growth factor binding protein-associated protein (IGFBPrP1) drives hepatic stellate cells (HSCs) activation, and IGFBPrP1 transforming β1 (TGFβ1) likely interact with each other to promote HSCs activation. TGFβ1 reportedly promotes autophagy contributes activation; however, the mechanism between in liver fibrogenesis is yet unknown. Moreover, long noncoding RNA (lncRNA) H19 participates regulation plays a crucial function fibrosis. To define...
It is well established that inhibition of glycogen synthase kinase (GSK)-3β in the young adult myocardium protects against ischemia-reperfusion (I/R) injury through mitochondrial permeability transition pore (mPTP) opening. Here, we investigated age-associated differences ability GSK-3β inhibitor [SB-216763 (SB)] to protect heart and modulate mPTP opening during I/R injury. Fischer 344 male rats were assigned from their respective or old age groups. Animals subjected 30 min ischemia...
This study focuses on the problems of poor control performance, synchronization performance and stability in multi-motor permanent magnet drive systems mining belt conveyors when a Proportional Integral Derivative (PID) controller is used to multi-motor. In this paper, system model for three-motor synchronous mine conveyor established. On basis, an Enhanced first-order Active Disturbance Rejection Controller (Efal_ADRC) designed based optimized nonlinear function. Additionally, weighted...
To improve the power output performance of high-power electrolytic plating equipment and enhance dynamic response disturbance resistance DC-DC converter, core component plating, a phase shifted full bridge converter predictive control strategy based on an improved nonlinear observer is proposed. Firstly, controller inner loop structure model algorithm constructed to capability current loop; Secondly, design estimate changes in electronic parameters external disturbances converter; Finally,...
To enhance the power output performance of high-power electrolytic plating equipment and improve dynamic response capability disturbance rejection ability DC-DC converter—a core component in systems—this study proposes a predictive control strategy for phase-shifted full-bridge converters based on an improved nonlinear observer. The implementation framework comprises three key technical components: Firstly, model (MPC)-based inner-loop controller architecture is constructed to optimize...