A5001807969- Immune Cell Function and Interaction
- Pancreatitis Pathology and Treatment
- T-cell and B-cell Immunology
- Lipid metabolism and disorders
- CAR-T cell therapy research
- Pancreatic and Hepatic Oncology Research
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Phagocytosis and Immune Regulation
- Fibroblast Growth Factor Research
- Monoclonal and Polyclonal Antibodies Research
- Diabetes Management and Research
- Telomeres, Telomerase, and Senescence
- Adipose Tissue and Metabolism
- Cytomegalovirus and herpesvirus research
- Lymphoma Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Diabetes Management and Education
Yangzhou University
2016-2025
University of California, San Diego
2025
Children's Hospital of Fudan University
2025
Integrated Chinese Medicine (China)
2015-2024
Pancreas Centre (Canada)
2022
Northern Jiangsu People's Hospital
2022
Nantong University
2022
XinHua Hospital
2021
Shanghai Jiao Tong University
2021
Peking University
2021
Oxidative stress plays a crucial role in the pathogenesis of acute pancreatitis (AP). Isoliquiritigenin (ISL) is flavonoid monomer with confirmed antioxidant activity. However, specific effects ISL on AP have not been determined. In this study, we aimed to investigate protective effect using two mouse models. caerulein-induced mild (MAP) model, dynamic changes oxidative injury pancreatic tissue were observed after onset. We found that administration reduced serum amylase and lipase levels...
INTRODUCTION: To investigate whether increased intrapancreatic fat deposition (IPFD) heightens the risk of diseases exocrine and endocrine pancreas. METHODS: A prospective cohort study was conducted using data from UK Biobank. IPFD quantified MRI a deep learning–based framework called nnUNet. The prevalence fatty change pancreas (FP) determined sex- age-specific thresholds. Associations between pancreatic were assessed with multivariate Cox-proportional hazard model adjusted for age, sex,...
Pyroptosis is a lytic form of pro-inflammatory cell death characterised as caspase 1 dependent with canonical NLRP3 inflammasome-induced gasdermin D (GSDMD) activation. We aimed to investigate the role acinar pyroptotic in pancreatic injury and systemic inflammation AP.Pancreatic pathway activation upon toxin stimulation vitro vivo was investigated. Effects pharmacological (NLRP3 caspase-1 inhibitors), constitutive (Nlrp3-/- , Casp1-/- Gsdmd-/- ) conditional (Pdx1Cre Nlrp3Δ/Δ Pdx1Cre...
Cellular senescence (CS) is recognized as a critical driver of aging and age-related disorders. Recent studies have emphasized the roles ion channels key mediators CS. Nonetheless, regulatory mechanisms chloride intracellular (CLICs) during CS remain largely unexplored. In this study, we conducted RNA sequencing on bleomycin-induced senescent lung tissues from mice identified Clic3 most significantly upregulated CLIC member. Furthermore, our findings revealed that knockdown CLIC3 mitigated...
Formononetin is a kind of isoflavone compound and has been reported to possess anti-inflammatory properties. In this present study, we aimed explore the protective effects formononetin on dextran sulfate sodium- (DSS-) induced acute colitis. By intraperitoneal injection in mice, disease severity colitis was attenuated dose-dependent manner, mainly manifesting as relieved clinical symptoms colitis, mitigated colonic epithelial cell injury, upregulations tight junction proteins levels (ZO-1,...
Aim To explore the relationship between spiritual climate and transformational leadership, examine their impact on nurses perceived emotional exhaustion intentions to quit. Background Transformational leadership is known have a significant positive effect work environment job satisfaction. Additionally, promoting amongst staff can benefit workers by increasing self-worth. The two unknown. Methods Nurse clinicians from 2 sites in Jiangsu Province of China completed self-report questionnaires...
Irisin is a newly discovered myokine which links exercise to inflammation and inflammation-related diseases through macrophage regulation. However, the effect of irisin on activity related immune cells (such as neutrophils) has not been clearly described.The objective our study was explore neutrophil extracellular traps (NETs) formation.Phorbol-12-myristate-13-acetate (PMA) used construct classic model that observe formation NETs in vitro. We studied its regulation mechanism. Subsequently,...
Bile acids are altered and associated with prognosis in patients acute pancreatitis (AP). Here, we conduct targeted metabolomic analyses to detect bile changes during the (n = 326) recovery 133) phases of AP, as well healthy controls 60). Chenodeoxycholic acid (CDCA) decreases phase, increases is pancreatic necrosis. CDCA its derivative obeticholic exhibit a protective effect against acinar cell injury vitro necrosis murine models, RNA sequencing reveals that oxidative phosphorylation...
This study aims to identify the role that spiritual climate has in reducing burnout and intentions leave amongst clinical nurses.Both shortages high turnover of nurses are challenging problems worldwide. Enhancing can enhance teamwork, organisational commitment job satisfaction play a intention.A total 207 working at tertiary university hospital were included this cross-sectional, single-site study. Independent-samples t test ANOVA, Pearson correlation analysis hierarchical regression used...
Abstract: Nanoparticles can be loaded with exogenous DNA for the potential expression of cytokines immune-stimulatory function. NKG2D identifies major histocompatibility complex class I chain-related protein in human and retinoic acid early induced transcript-1 mouse, which acts as tumor-associated antigens. Biologic agents based on interleukin 21 (IL-21) have displayed antitumor activities through lymphocyte activation. The NKG2D–IL-21 fusion theoretically tumor cells moiety activates T...
Abstract Uncoupling protein 1 (UCP1) catalyzes the leak of protons across mitochondrial inner membrane for thermogenesis. Compromised NK cell activity is involved in occurrence nonalcoholic liver fibrosis. Here, decreased UCP1 cells was identified patients with advanced fatty disease. Although no obvious changes were observed physiologic −/− mice (8–10 weeks old), impaired bioactivity shown methionine–choline-diet (MCD)-fed and acerbation steatohepatitis (NASH) progress to Moreover,...
A large number of natural killer (NK) cells with high function are expected to generate especially in tumor adoptive immunotherapy. Here K562 were genetically modified co-express major histocompatibility complex class I chain-related protein (MICA), 4-1BB ligand, and IL-15, called K562-MICA-4-1BBL-IL-15. The not only promoted activation, proliferation, survival NK cells, but also enhanced cell cytotoxicity. In long-term culture tests, K562-MICA-4-1BBL-IL-15 stimulated expand mean 550 folds...
Danshen (Salvia miltiorrhiza Bunge) and its main active component Tanshinone IIA (TSA) are clinically used in China. However, the effects of TSA on acute pancreatitis (AP) potential mechanism have not been investigated. In this study, our objective was to investigate protective against AP via three classic mouse models. Mouse models were established by caerulein, sodium taurocholate, L-arginine, separately. Pancreatic pulmonary histopathological characteristics serum amylase lipase levels...
5-Fluorouracil (5-FU) is a common anti-tumor drug, but there no effective treatment for its side effect, intestinal mucositis. The inflammatory reaction of macrophages in mucosa induced by 5-FU an important cause In this study, we investigated the anti-inflammatory effects three short-chain fatty acids (SCFAs), including sodium acetate (NaAc), propionate (NaPc), and butyrate (NaB), on human mononuclear macrophage-derived THP-1 cells 5-FU. expressions intracellular ROS,...
// Dongling Teng 1, 2, * , Keyan Wu Yunyun Sun Min Zhang 2 Dan Wang Jian Tao Yin Weijuan Gong Yanbing Ding Weiming Xiao Guotao Lu and Weiqin Li 3 1 Department of Gastroenterology, Affiliated Hospital Yangzhou University, 225000, Jiangsu, China Laboratory Surgical Intensive Care Unit (SICU), General Surgery, Jinling Hospital, Medical School Nanjing 210002, These authors contributed equally to this work Correspondence to: Lu, email: Gtlu@yzu.edu.cn Xiao, wmxiao@yzu.edu.cn Keywords: acute...
Colistin resistance has emerged worldwide and been threatening the efficacy of one last-resort antimicrobials used for treatment multidrug resistant Gram-negative bacteria. While five colistin genes (mcr-1, mcr-2, mcr-3, mcr-4 mcr-5) have described, few data are available on prevalence mcr-genes other than mcr-1 in human samples. In this study, presence currently described (mcr 1–5) vaginal swabs women undergoing infertility evaluation was reported. Most samples were found to be positive...