A5100757995- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Lipid metabolism and disorders
- Organ Transplantation Techniques and Outcomes
- Xenotransplantation and immune response
- Liver physiology and pathology
- Viral gastroenteritis research and epidemiology
- Liver Disease Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tissue Engineering and Regenerative Medicine
- Diabetes and associated disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Gallbladder and Bile Duct Disorders
- Mesenchymal stem cell research
- Streptococcal Infections and Treatments
- Metastasis and carcinoma case studies
- Intestinal and Peritoneal Adhesions
- Effects and risks of endocrine disrupting chemicals
- Bone and Dental Protein Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Periodontal Regeneration and Treatments
- Plant Disease Resistance and Genetics
- Cancer, Hypoxia, and Metabolism
- Caveolin-1 and cellular processes
Yangzhou University
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Nanjing University
2010-2022
Southern Medical University
2022
Nanjing Medical University
2012-2022
Nanjing General Hospital of Nanjing Military Command
2015-2021
Eastern Hepatobiliary Surgery Hospital
2015
Second Military Medical University
2015
Nanjing Drum Tower Hospital
2008-2014
INTRODUCTION: To investigate whether increased intrapancreatic fat deposition (IPFD) heightens the risk of diseases exocrine and endocrine pancreas. METHODS: A prospective cohort study was conducted using data from UK Biobank. IPFD quantified MRI a deep learning–based framework called nnUNet. The prevalence fatty change pancreas (FP) determined sex- age-specific thresholds. Associations between pancreatic were assessed with multivariate Cox-proportional hazard model adjusted for age, sex,...
Objectives: Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is one of the most common etiologies (AP) worldwide. Compared to other etiologies, patients with HTG-AP may develop more severe AP, but previous studies yielded controversial conclusion due lack adequate adjustment for confounders. Therefore, this study aimed examine possibility and risk factors developing AP in HTG-AP. Methods: Data from an established diagnosis were collected January 2013 December 2023 using a...
The selection of scaffold materials and the optimization morphological mechanical properties are critical for successful bone tissue engineering. We fabricated porous scaffolds nano-sized zirconia using a replication technique. study aimed to explore relationship between porosity, pore size, strength, cell adhesion, proliferation in scaffolds. Macro- micro-structures compressive strength were comparatively tested. Beagle marrow stromal cells seeded onto evaluate seeding efficiency profile...
Twenty-three percent of patients are diagnosed with diabetes mellitus after the first episode acute pancreatitis. The incidence post-acute pancreatitis is significantly higher than that type 1 mellitus. Some studies have concluded all-cause mortality and worse prognosis higher. We predicted number recurrences would be associated incidences metabolic syndrome, abdominal obesity, mellitus.Patients admitted to our hospital for hypertriglyceridemic from 2013-2021 were selected a cross-sectional...
Acute pancreatitis (AP) is the most common pancreatic disease. Predicting severity of AP critical for making preventive decisions. However, performance existing scoring systems in predicting was not satisfactory. The purpose this study to develop predictive models using machine learning (ML) algorithms and explore important predictors that affected prediction results.The data 441 patients Department Gastroenterology our hospital were analyzed retrospectively. demographic data, blood routine...
Objective: Hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is an increasingly recognized cause of pancreatitis, particularly in China. This study aims to establish a multi-center prospective cohort investigate the prevalence, clinical features, recurrence risk, and complications HTG-AP, provide insights into its pathophysiology management. Methods: Chinese Pancreatitis Study Group (CHPSG) launched prospective, multicenter observational across 12 tertiary hospitals Adult patients...
// Shengqi Zang 1, * , Lei Zhu 2, Kefu Luo 3 Rui Mu 4 Feng Chen 1 Xiaocui Wei Xiaodong Yan Biyao Han Xiaolei Shi Qintao Wang 5 and Jin Department of Stomatology, Jinling Hospital, Medical School Nanjing University, Nanjing, Jiangsu 210002, P.R. China 2 Prosthodontics, The Fourth Military Xi'an, Shaanxi 710023, Urumqi General Hospital PLA, 830000, Southern Guangzhou, Guangdong 510515, Periodontics, These authors contributed equally to this work Correspondence to: Jin, email: ljin@nju.edu.cn...
Hypertriglyceridemia (HTG) is one of the most common etiologies acute pancreatitis (AP). Variants in five genes involved regulation plasma lipid metabolism, namely LPL, APOA5, APOC2, GPIHBP1 and LMF1, have been frequently reported to cause or predispose HTG. A Han Chinese patient with HTG-induced AP was assessed for genetic variants by Sanger sequencing entire coding flanking sequences above genes. The a 32-year-old man severe obesity (Body Mass Index = 35) heavy smoking (ten cigarettes per...
Abstract Background Hypertriglyceridemia (HTG) is a leading cause of acute pancreatitis. HTG can be caused by either primary (genetic) or secondary etiological factors, and there increasing appreciation the interplay between two kinds factors in causing severe HTG. Objectives The main aim this study was to identify genetic basis hypertriglyceridemia-induced pancreatitis (HTG-AP) Chinese family with three affected members (the proband, his mother older sister). Methods entire coding flanking...
AIM:To evaluate tracking of magnetically labeled mesenchymal stem cells (MSCs) after intraportal transplantation.METHODS: Mononuclear were isolated from bone marrow aspirates pigs by density gradient centrifugation, cultured and expanded, which, they incubated with super paramagnetic iron oxide (SPIO).Prussian blue staining was performed to highlight intracellular iron.To establish swine models acute liver injury, 0.5 g/kg D-galactosamine administrated 10 pigs, six which injected via their...
Variants in the lipoprotein lipase (LPL), apolipoprotein C-II (APOC2), A-V (APOA5), GPIHBP1 and LMF1 genes may cause severe hypertriglyceridemia (HTG), which is now second-leading aetiology of acute pancreatitis China. The patient his family were assessed for gene variants by Sanger sequencing exons exon-intron junctions LPL, GPIHBP1, APOA5, APOC2, genes. Post-heparin blood was collected LPL mass activity detection. had suffered from long-term recurrent abdominal pain over 30 years, since...
The etiology of hypertriglyceridemia (HTG) and acute pancreatitis (AP) is complex. Herein, we dissected the underlying in a patient with HTG AP. had 20-year history heavy alcohol consumption an 8-year mild HTG. He was hospitalized for alcohol-triggered AP, plasma triglyceride (TG) level up to 21.4 mmol/L. A temporary rise post-heparin LPL concentration (1.5–2.5 times controls) noted during early days AP whilst activity consistently low (50∼70% controls). His TG rapidly decreased normal...
Abstract Background Acute pancreatitis in pregnancy (APIP) is a life‐threatening disease for both mother and fetus. To date, only three patients with recurrent hypertriglyceridemia‐induced APIP (HTG‐APIP) have been reported to carry rare variants the lipoprotein lipase ( LPL ) gene, which encodes key enzyme responsible triglyceride (TG) metabolism. Coincidently, all harbored on alleles presented complete or severe deficiency. Methods The entire coding regions splice junctions of four other...
Severe acute pancreatitis (SAP) is characterized by high mortality rates and various complications, including skeletal muscle atrophy, which significantly exacerbates its outcomes. Despite clinical relevance, the mechanistic understanding of relationship between pancreas in SAP remains limited. Our study aimed to elucidate this "organ crosstalk" potential implications. We established an mouse model through pancreatic duct ligation (PDL) evaluated necrosis, myonectin expression levels....
Introduction The aim of our study is to explore the value serum glycosylated hemoglobin A1c (HbA1c) in disease severity and clinical outcomes acute pancreatitis (AP). Research design Methods Patients with AP were included from January 2013 December 2020, retrospectively, dividing into normal HbA1c level (N-HbA1c) group high (H-HbA1c) according criteria <6.5%. We compared patient characteristics, biochemical parameters, severity, patients two groups. Besides, we evaluated efficacy predict...
Background: Acute pancreatitis in pregnancy is a rare but highly life-threatening gestational and perinatal disease. Objective: This study aimed to identify the risk factors for fetal death acute severity. Methods: retrospective cohort enrolled patients with our center from January 1, 2012, August 2020, classified them according two clinical endpoints, outcome disease The groups were examined compared week, etiology, gravidity parity, complications pre- post-delivery, medical history....
Tissue regeneration is the preferred treatment for dentin and bone tissue defects. Dental pulp stem cells (DPSCs) have been extensively studied their use in regeneration, including of tissue. LIM mineralization protein-1 (LMP-1) an intracellular non-secretory protein that plays a positive regulatory role process. In this study, LMP-1-induced DPSCs model was used to explore effect LMP-1 on proliferation odonto/osteogenic differentiation DPSCs, as well underlying mechanisms. As indicated by...
Our previous report suggested that chitosan nanofiber scaffold may find application in bioartificial livers for it could enhance the function of hepatocytes. This study was focused on its microbiological safety, is, influence expression and infectivity porcine endogenous retrovirus (PERV) primary Freshly isolated hepatocytes were cultured with or without (defined as Exp group Ctr group) kidney 15 (PK15) cells positive control PK15 group). The supernatant removed substituted new culture media...
Objectives: to investigate the factors influencing transfer of porcine endogenous retroviruses (PERVs) across membrane in a new bioartificial liver (BAL). Methods: A BAL containing 2 circuits was constructed using plasma component separators with pore sizes 10 nm, 20 30 and 35 or filter size 500 nm. Cocultured cells hepatocytes mesenchymal stem single were incubated bioreactors, worked for 72 hours, supernatant samples internal external collected every 12 hours. PERV RNA, reverse...