A5107658809- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Nutrition, Genetics, and Disease
- Colorectal Cancer Screening and Detection
- Pancreatitis Pathology and Treatment
- Lipid metabolism and disorders
- Pancreatic and Hepatic Oncology Research
- RNA Research and Splicing
- Photodynamic Therapy Research Studies
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Advanced Nanomaterials in Catalysis
- Chemokine receptors and signaling
- Circular RNAs in diseases
- Helicobacter pylori-related gastroenterology studies
- Molecular Communication and Nanonetworks
- Energy Efficiency and Management
- Cancer Cells and Metastasis
- Folate and B Vitamins Research
- Cervical and Thoracic Myelopathy
- Heat shock proteins research
Nanjing Medical University
2016-2025
Nanjing General Hospital of Nanjing Military Command
2016-2025
Suzhou Municipal Hospital
2025
Yangzhou University
2025
Hangzhou Normal University
2025
Nanjing University
2016-2024
Shanghai First People's Hospital
2020-2024
Shanghai Jiao Tong University
2020-2024
National Taiwan University Hospital
2024
National Yang Ming Chiao Tung University
2024
Abstract The demand for transporting coreactant to emitter and short lifetime of the radicals in electrochemiluminescence (ECL) emission inhibit greatly its application cytosensing microscopic imaging. Herein we designed a dual intramolecular electron transfer strategy tertiary amine conjugated polymer dots (TEA‐Pdots) develop coreactant‐embedded ECL mechanism microimaging system. TEA‐Pdots could produce at +1.2 V without need test solution. superstructure led unprecedented strength, which...
Taking advantage of cancer cells' endogenous characters, the responsive activation DNA nanomachines has achieved great success in tumor therapy. Combining with extra stimuli such as external light irradiation provided spatiotemporal control nanomachine activation. However, specific at cellular level is still challenging considering macroscopic-scale exposure area usual sources. logic gates located cell membrane contributed to specificity, but free diffusion input strands during operation...
Abstract Stimuli‐responsive photodynamic therapy (PDT) is a hot topic in precise medicine, but the low abundance of responsive trigger molecules early‐stage disease limits application. Here we designed an amplifier with multiple upconversion luminances to achieve near‐infrared photo‐switched cascade reaction triggered by specific microRNA and PDT cancers. This was composed photo‐caged DNA nanocombs nanoparticle (UCNP) sensitized IRDye 800CW. The nanocomb prepared assembling...
Endothelial cells (ECs) in the tumor microenvironment have been reported to play a more active role solid growth and metastatic dissemination than simply providing physical structure form conduits for blood flow; however, involvement of ECs process triple-negative breast cancer (TNBC) metastasis has not addressed. Here, we demonstrate that ECs—when mixed with TNBC cells—could increase cell potency. After treatment TGF-p induce endothelial-mesenchymal transition (EMT), could produce...
The development of electrochemiluminescence (ECL) emitters remains a great research interest in ECL analysis. Herein, luminol-doped polymer dots (L-Pdots) and diethylamine-coupled Pdots (N-Pdots) were synthesized to design both potential- color-resolved strategy. L-Pdots showed the maximum emission at 450 nm presence hydrogen peroxide +0.6 V, while N-Pdots was 675 under +1.0 V. This strategy conveniently used construct novel array imaging method for high-throughput detection two microRNAs...
The F box protein Skp2 is oncogenic. and Skp2B, an isoform of are overexpressed in breast cancer. However, little known regarding the mechanism by which Skp2B promotes occurrence development Here, we determined expression clinical outcomes cancer samples cell lines using database, investigated role growth, apoptosis cycle arrest. We obtained significantly lines, high positively correlated with poor prognosis Both could promote proliferation, inhibit apoptosis, change distribution induce...
Background: Serum Cystatin S (CST4), a secretory protein that inhibits cellular matrix degradation, significantly influences the tumor microenvironment and progression. However, prognostic value of serum CST4 in gastric cancer (GC) remains unclear. This study aims to explore CST4’s utility GC assessment. Methods: A cohort 334 patients with who underwent radical gastrectomy was assessed. Preoperative levels were measured alongside traditional markers, correlating clinical data patient...
Objective: This study aimed to investigate whether the dysregulation of Aurora-A is involved in lenvatinib resistance hepatocellular carcinoma. Methods: Bioinformatics tools and drug sensitivity assays were used association between expression level carcinoma cell lines. Cell function experiments had performed after treatment with and/or a selective inhibitor (MLN-8237). CircRNA microarray, RIP, RNA pull-down, dual-luciferace reporter assay identify downstream molecular mechanism...
<p>Effect of genetic and lifestyle factors on the risk incident colorectal cancer stratified by sex. The cumulative incidence in low (quintile 1), intermediate (quintiles 2–4), high 5) groups men (A) women (B), P for heterogeneity = 0.102. participants who had a favorable (adopted at least four healthy factors), an two or three unfavorable none one factor) (C) (D), 0.979. Abbreviations: CI, confidence interval; HR, hazards ratio.</p>
<p>Effect of genetic risk and lifestyle factors on the colorectal cancer in PLCO cohort. (A) Participants were divided into five equal groups (quintiles) according to polygenic score, HRs for each group compared with those quintile 1 score; error bars show 95% CIs. (B) seven number healthy factors, who adopted no factor; Abbreviations: CI, confidence interval; HR, hazards ratio; PLCO, Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial.</p>
<p>More information of the most comprehensive GWAS for CRC up to date</p>
<p>Ten-year colorectal cancer absolute risk, according to lifestyle and genetic risk in the PLCO cohort. Abbreviations: PLCO, Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial; PRS, polygenic score.</p>