A5100462484- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Luminescence and Fluorescent Materials
- Biosensors and Analytical Detection
- Advanced Nanomaterials in Catalysis
- DNA and Nucleic Acid Chemistry
- Advanced Photocatalysis Techniques
- Advanced Biosensing Techniques and Applications
- Graphene research and applications
- Photosynthetic Processes and Mechanisms
- Luminescence Properties of Advanced Materials
- Molecular Sensors and Ion Detection
- RNA modifications and cancer
- X-ray Diffraction in Crystallography
- Cancer-related molecular mechanisms research
- Crystallization and Solubility Studies
- TiO2 Photocatalysis and Solar Cells
- ZnO doping and properties
- Electrochemical sensors and biosensors
- Photodynamic Therapy Research Studies
- Extracellular vesicles in disease
- Advanced optical system design
- Advanced SAR Imaging Techniques
- Mitochondrial Function and Pathology
Nanjing University
2010-2025
Shaanxi Normal University
2014-2025
Children's Hospital of Fudan University
2025
Dalian Minzu University
2025
Chongqing University
2023-2024
Sichuan University
2017-2024
Guiyang Medical University
2024
The First People's Hospital of Changde
2023-2024
Xi'an Honghui Hospital
2024
Xi'an Jiaotong University
2024
Optical properties of highly ordered Ge nanopillar arrays are tuned through shape and geometry control to achieve the optimal absorption efficiency. Increasing materials filling ratio is shown increase reflectance while simultaneously decreasing transmittance, with absorbance showing a strong diameter dependency. To enhance broad band optical efficiency, novel dual-diameter structure presented, small tip for minimal large base maximal effective coefficient. The enabled single-crystalline...
Metal-catalyzed crystallization of amorphous carbon to graphene by thermal annealing is demonstrated. In this “limited source” process scheme, the thickness precipitated directly controlled initial layer. This in contrast chemical vapor deposition processes, where source virtually unlimited and controlling number layers depends on tight control over a parameters. Based Raman analysis, quality comparable other synthesis methods found literature, such as deposition. The ability synthesize...
Abstract Tumor response to radiotherapy or ferroptosis is closely related hydroxyl radical (•OH) production. Noninvasive imaging of •OH fluctuation in tumors can allow early monitoring therapy, but challenging. Here, we report the optimization a diene electrochromic material (1-Br-Et) as •OH-responsive chromophore, and use it develop near-infrared ratiometric fluorescent photoacoustic (FL/PA) bimodal probe for vivo •OH. The displays large FL ratio between 780 1113 nm (FL /FL ), small PA 755...
Direct application of benzyl alcohols (or their magnesium salts) as electrophiles in various reactions with Grignard reagents has been developed via transition metal-catalyzed sp(3) C-O bond activation. Ni complex was found to be an efficient catalyst for the first direct cross coupling aryl/alkyl reagents, while Fe, Co, or catalysts could promote unprecedented conversion presence (n)hexylMgCl. These methods offer straightforward pathways transform into a variety functionalities.
Abstract Stimulus‐responsive drug release possesses considerable significance in cancer therapy. This work reports an upconversion‐luminescence‐fueled DNA–azobenzene nanopump for rapid and efficient release. The is constructed by assembling the azobenzene‐functionalized DNA strands on upconversion nanoparticles (UCNPs). Doxorubicin (DOX) loaded intercalation helix. Under NIR light, UCNPs emit both UV visible photons to fuel continuous photoisomerization of azo, which acts as impeller pump...
A phosphorylation of alkenyl and aryl C–O bonds at room temperature via photoredox/nickel dual catalysis is reported. By starting from easily available inexpensive sulfonates, a variety important phosphonates phosphine oxides are generated in moderate to excellent yields. This method features mild reaction conditions, high selectivity, good functional group tolerance, wide substrate scope, easy scalability.
Taking advantage of cancer cells' endogenous characters, the responsive activation DNA nanomachines has achieved great success in tumor therapy. Combining with extra stimuli such as external light irradiation provided spatiotemporal control nanomachine activation. However, specific at cellular level is still challenging considering macroscopic-scale exposure area usual sources. logic gates located cell membrane contributed to specificity, but free diffusion input strands during operation...
A photo zipper locked DNA nanomachine with an internal standard is presented, preventing nonspecific activation and providing efficient intracellular miRNA imaging.
The controllable growth of metal nanoparticles on nanomaterials is becoming a useful strategy for developing nanocomposites with designated performance. Here, DNA-controlled Pt graphene oxide (GO–PtNPs) to regulate the nanozyme activity and triplex-hybridization chain reaction (tHCR) triggering assembly DNA probes amplify target-induced catalytic signal were designed. tHCR one linear two hairpin could be specially triggered by trigger form long double-stranded structure in presence target...
Abstract Stimuli‐responsive photodynamic therapy (PDT) is a hot topic in precise medicine, but the low abundance of responsive trigger molecules early‐stage disease limits application. Here we designed an amplifier with multiple upconversion luminances to achieve near‐infrared photo‐switched cascade reaction triggered by specific microRNA and PDT cancers. This was composed photo‐caged DNA nanocombs nanoparticle (UCNP) sensitized IRDye 800CW. The nanocomb prepared assembling...
Cytoplasmic male sterility (CMS) determined by mitochondrial genes and restorer of fertility ( Rf ) controlled nuclear-encoded provide the breeding systems many hybrid crops for utilization heterosis. Although several CMS/ have been widely exploited in rice, using these has encountered difficulties due to either instability or complications two-locus inheritance both. In this work, we characterized a type CMS, Fujian Abortive cytoplasmic (CMS-FA), with stable sporophytic nuclear gene that...
A high catalytic efficiency associated with a robust chemical structure are among the ultimate goals when developing new biocatalytic systems for biosensing applications. To get ever closer to these goals, we report here on combination of metal–organic framework (MOF)-based nanozymes and G-quadruplex (G4)-based system known as G4-DNAzyme. This approach aims at combining advantages both partners (chiefly, robustness former modularity latter). this end, used MIL-53(Fe) MOF linked it covalently...
Gesture recognition systems epitomize a modern and intelligent approach to rehabilitative training, finding utility in assisted driving, sign language comprehension, machine control. However, wearable devices that can monitor motivate physically rehabilitated people real time remain little studied. Here, we present an innovative gesture system integrates hydrogel strain sensors with learning facilitate finger rehabilitation training. PSTG (PAM/SA/TG) hydrogels are constructed by thermal...
Simultaneous profiling of multiple molecules trafficking at a single organelle and the surrounding cytosol within living cell is crucial for elucidating their functions, necessitating advanced techniques that provide high spatial–temporal resolution molecule specificity. In this study, we present an electrochemical nanodevice based on θ-nanopipette designed to coanalyze calcium ions (Ca 2+ ) reactive oxygen species (ROS) mitochondrion its cytosol, thereby enhancing our understanding...
A single microbead-based sensing platform has been developed, which enables the detection of microRNA at single-molecule level.
Abstract Despite the successful application of upconversion nanoparticles (UCNPs), their low energy transfer efficiency is still a bottleneck to further applications. Here we design UCNPs with multilayer structure, including an inert NaYF 4 :Gd core and energy‐concentrating zone (ECZ), for efficient concentration. The ECZ composed emitting layer :Yb,Er absorption :Nd,Yb antenna IRDye 800CW manipulate transfer. stable tight packing linked originally bisphosphonate ligand improves greatly...
The in situ generation of siRNAs living cells can greatly enhance the specificity and efficiency gene therapy. Inspired by natural molecular machines that organize different compartments sequentially a limited space to facilitate cellular process, this work constructs DNA nanomachine (DNM) alternately hybridizing two pairs DNA/RNA hybrids scaffold generated rolling circle amplification for highly efficient siRNA assembly cells. After target cell-specific delivery DNM, intracellular specific...
G-quadruplex/hemin (G4/hemin) DNAzymes are biosensing systems, but their application remains limited by an overall low activity and a rather high level of unwarranted background reactions. Here, these issues were addressed through the rational design F3T-azaC-hemin, G4-based construct in which hemin is covalently linked to G4 core its binding site flanked with nucleotide activator, here d(T-azaC). This led G4-DNAzyme whose performances have been ca. 150-fold increased compared parent system....
Chimeric peptide-DNAzyme (CPDzyme) is a novel artificial peroxidase that relies on the covalent assembly of DNA, peptides, and an enzyme cofactor in single scaffold. An accurate control these different partners allows for design CPDzyme prototype G4-Hemin-KHRRH, found to be >2000-fold more active (in terms conversion number kcat) than corresponding but non-covalent G4/Hemin complex and, importantly, >1.5-fold native (horseradish peroxidase) when considering catalytic center. This unique...
Thermionic emission from multiwalled carbon nanotubes (MWNTs) was investigated by using MWNT yarns. The work function of and thermionic constant the yarn sample were both calculated data. measured is about $4.54--4.64\phantom{\rule{0.3em}{0ex}}\mathrm{eV}$. larger than conventional cathode. electron energy spectra at various temperatures have also been as cathode in an momentum instrument. full width half maximum show a linear relation with temperature. nanotube may be used to replace for...
The induction of vascular endothelial growth factor (VEGF) is an essential feature tumor angiogenesis. Hypoxia a potent stimulator VEGF expression, and hypoxia-inducible factor-1 (HIF-1) considered to be critical for this induction. However, we have previously demonstrated that by hypoxia was preserved when HIF-1α silenced. We sought better define the molecular basis HIF-1-independent regulation. In colon cancer cells, stimulated multiple K-ras effector pathways including...