A5100707958- Thyroid Cancer Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Optical Imaging and Spectroscopy Techniques
- Glaucoma and retinal disorders
- Gastric Cancer Management and Outcomes
- Bone and Joint Diseases
- Retinal Diseases and Treatments
- Radiopharmaceutical Chemistry and Applications
- Prostate Cancer Treatment and Research
- Medical Imaging Techniques and Applications
- Ophthalmology and Eye Disorders
- Photoacoustic and Ultrasonic Imaging
- Hip disorders and treatments
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Multiple Myeloma Research and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Retinal Imaging and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Cerebral Venous Sinus Thrombosis
- Orthopedic Infections and Treatments
- Renal and related cancers
- Corneal surgery and disorders
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
Peking University
2019-2025
Peking University Third Hospital
2019-2025
First Hospital of Shanxi Medical University
2025
Shanxi Medical University
2022-2025
Guangzhou Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Peking Union Medical College Hospital
2015-2024
Shandong First Medical University
2024
Tongji Hospital
2024
Huazhong University of Science and Technology
2023-2024
Glucocorticoids play a pivotal role in the proliferation of osteoblasts, but underlying mechanism has not been successfully elucidated. In this report, we have investigated molecular which elucidates inhibitory effects dexamethasone on murine osteoblastic MC3T3-E1 cells. It was found that were largely attributed to apoptosis and G1 phase arrest. Both cell cycle arrest dependent glucocorticoid receptor (GR), as they abolished by GR blocker RU486 pre-treatment interference. accompanied with...
As a debilitating condition that can impact whole spectrum of people and involve multi-organ systems, long COVID has aroused the most attention than ever. However, mechanisms are not clearly understood, underlying biomarkers affect long-term consequences COVID-19 paramount to be identified.
The proliferation of retinal pigment epithelium (RPE) cells resulting from an epithelial-mesenchymal transition (EMT) plays a key role in proliferative vitreoretinopathy (PVR), which leads to complex detachment and the loss vision. Genes Snail family encode zinc finger transcription factors that have been reported be essential EMT during embryonic development cancer metastasis. However, function RPE undergoing is largely unknown.Transforming growth factor beta(TGF-β)-1 resulted human...
Abstract We recently identified CD46 as a novel prostate cancer cell surface antigen that shows lineage independent expression in both adenocarcinoma and small neuroendocrine subtypes of metastatic castration resistant (mCRPC), discovered an internalizing human monoclonal antibody YS5 binds to tumor selective epitope, developed microtubule inhibitor-based drug conjugate is multi-center phase I trial for mCRPC (NCT03575819). Here we report the development CD46-targeted alpha therapy based on...
Lymphocyte decline, particularly the depletion of NK cells, is a prominent feature immunosuppression following severe tissue injury, heightening susceptibility trauma patients to life-threatening infections. Previous research indicates that reduction in number cells closely associated with process cell death. Nonetheless, precise mechanism death remains unknown. Here, we discovered traumatic undergo several pathways, dominated by apoptosis and pyroptosis coexistence necrotic death,...
Summary Objective Whether the initiating time of radioiodine ( RAI ) therapy will affect clinical outcome in differentiated thyroid cancer DTC remains controversial. The objective this study was to evaluate impact on response initial low‐ intermediate‐risk . Methods A total 235 consecutive patients with were retrospectively reviewed. According interval between thyroidectomy and therapy, divided into Group 1 (interval < 3 months, n = 187) 2 ≥ 48). Response evaluated as excellent,...
Abstract Background Myc rearrangement (Myc‐R) is a controversial factor linked to adverse outcomes in newly diagnosed multiple myeloma (NDMM). Aims This study aimed evaluate the impact of Myc‐R on prognosis NDMM patients and its role risk stratification compared with traditional high‐risk cytogenetic abnormalities (HRCAs). Materials & Methods A total 417 enrolled from May 2009 September 2022 were included. Fluorescence situ hybridization (FISH) was used detect other (Myc‐OA). Median...
<title>Abstract</title> <bold>Objective</bold> To describe the imaging features of osteonecrosis femoral head (ONFH) on fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and explore value PET/CT in assessing ONFH patients with lymphoma.<bold>Methods</bold> A retrospective analysis was conducted clinical data, PET/CT, MRI manifestations 17 lymphoma. The FDG uptake recorded, maximum standardized (SUV<sub>max</sub>) measured. staging extent ONFH, other bone involvements, were...
Coal worker's pneumoconiosis (CWP) is characterized by chronic inflammation and pulmonary fibrosis. The key factor contributing to the incurability of CWP unclear pathogenesis. This study explored characteristic changes in proteomics metabolomics early advanced patients through techniques. Proteomics identified proteins that change with progression CWP, significant enrichment TGF-β signaling pathway autoimmune disease pathways. Metabolomics revealed metabolic characteristics at different...
Space and astrophysical plasmas exhibit electromagnetic fluctuations inhomogeneous structures across a wide range of scales. In the turbulent magnetosheath, high-frequency whistler waves are closely associated with large-scale coherent such as magnetic holes. Our study presents statistical evidence on generation diffusion efficiency two distinct groups modes. Temperature-anisotropy beam-type instabilities triggered at different stages hole evolution. We introduce quasi-linear model...
Knowledge of the optical properties human whole blood has always been great interest for medical applications. The aim this study was to provide dispersive relations refractive index with different types in visible and near-infrared ranges other conditions. In order overcome scattering effect, we applied an unusual method based on total internal reflection. A focused light, a semicylindrical lens contact tissues linear CCD camera are used experimental apparatus. critical angle therefore can...
Purpose: To characterize the phenotypic variability and report genetic defects in a cohort of Chinese patients with biallelic variants retinol dehydrogenase 12 ( RDH12 ) gene. Methods: The study included 38 from unrelated families pathogenic variants. Systematic next-generation sequencing data analysis, Sanger validation, segregation analysis were used to identify mutations. Detailed ophthalmic examinations, including electroretinogram, fundus photography, autofluorescence optical coherence...
Current diagnosis of radioactive iodine (RAI)-refractory (RAIR) differentiated thyroid cancer (DTC) is based on the imaging technique, which a high cost. Serum thyroglobulin (Tg) sensitive and easily obtained biomarker. Hence, we aimed to assess predicting value quantitative response Tg in earlier identifying RAIR-DTC with pulmonary metastasis.Pulmonary metastatic DTC patients who underwent total or near-total thyroidectomy at least two times RAI therapy were included this study. The...
BACKGROUND:The combined effects of bilateral corticospinal tract (CST) reorganization and interhemispheric functional connectivity (FC) on motor recovery upper lower limbs after stroke remain unknown. MATERIAL AND METHODS:A total 34 patients underwent magnetic resonance imaging (MRI) examination at weeks 1, 4, 12 stroke, with a control group healthy subjects receiving 1 MRI examination. Interhemispheric FC in the somatomotor network (SMN) was calculated using resting-state (rs-fMRI)....
Steroid-induced osteonecrosis of the femoral head (SONFH) is a common clinical disease caused by massive or prolonged use steroids. Its pathogenesis unclear, but its incidence increasing annually. It characterized an insidious and rapid onset, high disability rate, causing great burden on patients' daily life. Therefore, clarifying providing early effective treatment for steroid important.In vivo, we used methylprednisolone (MPS) to construct SONFH rat model employed Mirco-ct, Hematoxylin...
Synaptic dysfunction and neuronal loss are related to cognitive impairment of Alzheimer’s disease. Recent evidence indicates that regulating the phosphatidylinositol 3-Kinase (PI3K)/AKT/GSK-3β pathway is a therapeutic strategy for improving synaptic plasticity in Here, we investigated “olfactory three-needle” effects on function PI3K/AKT/GSK-3β signaling β-amyloid1-42 (Aβ1-42)-induced disease rats. A three-needle olfactory bulb insertion 28 days alleviated Aβ1-42-induced rats’ as assessed by...
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation and joint damage, leading to pain reduced function. Icariin, a flavonoid compound, has been studied for its potential therapeutic role in RA due anti-inflammatory anti-proliferative effects. Here, we aimed investigate the action mechanism of icariin regulating RA.