A5065342121- SARS-CoV-2 and COVID-19 Research
- Pancreatic function and diabetes
- COVID-19 Clinical Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advanced Glycation End Products research
- Autophagy in Disease and Therapy
- Animal Virus Infections Studies
- Mesenchymal stem cell research
- Animal Disease Management and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Neonatal Respiratory Health Research
- Diabetes and associated disorders
- Neuroblastoma Research and Treatments
- Virus-based gene therapy research
- Long-Term Effects of COVID-19
- Microtubule and mitosis dynamics
- Neuroendocrine Tumor Research Advances
- Diabetes Management and Research
- Circular RNAs in diseases
- Viral gastroenteritis research and epidemiology
- Tissue Engineering and Regenerative Medicine
- Cancer Cells and Metastasis
- Organ Transplantation Techniques and Outcomes
- COVID-19 epidemiological studies
- Ferroptosis and cancer prognosis
China-Japan Friendship Hospital
2016-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Capital Medical University
2025
Hebei University of Engineering
2024
Shanghai Institute of Materia Medica
2024
Chinese Academy of Sciences
2024
Chinese University of Hong Kong
2010-2015
University of Hong Kong
2007-2015
Renmin University of China
2009
Hsin Sheng College of Medical Care and Management
2008
Growing evidence suggests that symptoms associated with post-COVID-19 condition (also known as long COVID) can affect multiple organs and systems in the human body, but their association viral persistence is not clear. The aim of this study was to investigate SARS-CoV-2 diverse tissues at three timepoints following recovery from mild COVID-19, well its COVID symptoms.
Abstract Lung injury and fibrosis represent the most significant outcomes of severe acute lung disorders, including COVID-19. However, there are still no effective drugs to treat fibrosis. In this study, we report generation clinical-grade human embryonic stem cells (hESCs)-derived immunity- matrix-regulatory (IMRCs) produced under good manufacturing practice requirements, that can in vivo. We generate IMRCs by sequentially differentiating hESCs with serum-free reagents. possess a unique...
As a debilitating condition that can impact whole spectrum of people and involve multi-organ systems, long COVID has aroused the most attention than ever. However, mechanisms are not clearly understood, underlying biomarkers affect long-term consequences COVID-19 paramount to be identified.
SARS-CoV-2-specific adaptive immunity more than 1 year after initial infection has not been well characterised. The aim of this study was to investigate the durability and cross-reactivity immunological memory acquired from natural against SARS-CoV-2 in individuals recovered COVID-19 2 years infection.
Abstract Acute lung injury (ALI) is an important pathological process of acute respiratory distress syndrome, yet there are limited therapies for its treatment. Mesenchymal stem cells-derived exosomes (MSCs-Exo) have been shown to be effective in suppressing inflammation. However, the effects MSCs-Exo on ALI and underlying mechanisms not well elucidated. Our data showed that MSCs-Exo, but derived from MRC-5 cells (MRC-5-Exo), which human fetal fibroblast cells, significantly improved chest...
ABSTRACT Pulmonary fibrosis is a pathological manifestation that occurs upon lung injury and subsequence aberrant repair with poor prognosis. However, current treatment limited does not distinguish different disease stages. Here, we aimed to study the differential functions of Axl, receptor tyrosine kinase expressing on both macrophages fibroblasts, in whole course pulmonary fibrosis. We used mice Axl total knockout, conditionally knockout or treating inhibitors inflammation stages examine...
Recently, Zika virus (ZIKV) outbreak has been associated with a sharp increase in cases of Guillain-Barré syndrome and severe fetal abnormalities. However, the mechanism underlying interaction ZIKV host cells is not yet clear. Axl, receptor tyrosine kinase, postulated as for entry; however, its vivo role during infection impact on outcome disease have fully characterized evaluated. Moreover, there are contradictory results involvement infection. Here we utilized Axl-deficient mice (Axl-/-)...
A series of bismuth complexes were synthesized and characterized, most them exhibited inhibition against the SARS coronavirus helicase ATPase duplex-unwinding activities at micromolar concentrations.
Controlled delivery of myofibril components to the appropriate sites assembly is crucial for myofibrillogenesis. Here, we show that kinesin-1 heavy chain Kif5b plays important roles in anterograde transport α-sarcomeric actin, non-muscle myosin IIB, together with intermediate filament proteins desmin and nestin growing tips elongating myotubes. Mice conditionally knocked out myogenic cells showed aggregation actin filaments differentiating skeletal muscle cells, which further affected their...
OBJECTIVE Suppression of Kinesin-1 by antisense oligonucleotides, or overexpression dominant-negative acting kinesin heavy chain, has been reported to affect the sustained phase glucose-stimulated insulin secretion in β-cells vitro. In this study, we examined vivo physiological role β-cell development and function. RESEARCH DESIGN AND METHODS A Cre-LoxP strategy was used generate conditional knockout mice which Kif5b gene is specifically inactivated pancreatic β-cells. Physiological...
It is unknown whether antibody-mediated enhancement (ADE) contributes to the pathogenesis of COVID-19, and conditions for ADE needs be elucidated. We demonstrated that without inducing an ACE2-independent on Raji cells, neutralizing antibody CB6, a mouse anti-S1 serum convalescent plasma, induced cells expressing FcγRIIA/CD32A low levels endogenous ACE2. occurred at sub-neutralizing concentrations, indicating unneutralized S protein was required ADE. The enhanced infectivity 614G variant...
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease. Whether extracellular vesicles are effective in treating IPF what the optimal administrative route not clear. Our previous studies have shown that immunity matrix regulatory cells (IMRCs) derived from human embryonic stem can safely treat injury mouse models, its mechanism of action related to paracrine effect. In this study, we investigated therapeutic effects IMRC-derived (IMRC-EVs) on...
Objective: Gliomas are the most common primary tumors in central nervous system with a bad prognosis. Pyroptosis, an inflammatory form of regulated cell death, plays vital role progression and occurrence tumors. However, value pyroptosis related genes (PRGs) glioma remains poorly understood. This study aims to construct PRGs signature risk model explore correlation clinical characteristics, prognosis, tumor microenviroment (TME), immune checkpoints. Methods: RNA sequencing profiles relevant...
Background and Aims: Increased intestinal permeability exacerbates the development of metabolic dysfunction associated steatohepatitis (MASH), but underlying mechanisms remain unclear. Autophagy is important for maintaining normal permeability. Here, we investigated impact transcription factor EB (TFEB), a key regulator autophagy, in MASH progression. Methods: TFEB expression was analyzed proximal colon 45 individuals with steatotic liver disease 23 healthy controls. We utilized...
Coronaviruses (CoV) mature by a budding process at intracellular membranes. Here we showed that the major surface protein S of porcine CoV (transmissible gastroenteritis virus) is not transported to cell but retained intracellularly. Site-directed mutagenesis indicated tyrosine-dependent signal (YXXI) in cytoplasmic tail essential for localization protein. Surface expression mutant proteins was evident immunofluorescence analysis and biotinylation. Intracellularly only contained...
Abstract Aims/Introduction Blockade or reversal the progression of diabetic nephropathy is a clinical challenge. The aim present study was to examine whether recombinant human glucagon‐like peptide‐1 (rh GLP ‐1) has an effect on alleviating urinary protein and albumin levels in rats. Materials Methods Streptozotocin‐induced diabetes rats were treated with rh ‐1 insulin saline. Using immunostaining, hematoxylin–eosin, electron microscopy periodic acid–Schiff staining pathology nephropathy, we...