A5100448413- Epigenetics and DNA Methylation
- Bacterial Infections and Vaccines
- Macrophage Migration Inhibitory Factor
- Pneumonia and Respiratory Infections
- Genetic Syndromes and Imprinting
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Tryptophan and brain disorders
- Multiple Sclerosis Research Studies
- MicroRNA in disease regulation
- Physical Education and Training Studies
- Intensive Care Unit Cognitive Disorders
- Meningioma and schwannoma management
- Flavonoids in Medical Research
- Inflammasome and immune disorders
- Facial Trauma and Fracture Management
- Neonatal and Maternal Infections
- Curcumin's Biomedical Applications
- Cardiac Health and Mental Health
- Cardiac Valve Diseases and Treatments
- Thermal Regulation in Medicine
- Kruppel-like factors research
- COVID-19 Clinical Research Studies
- Magnesium Alloys: Properties and Applications
- Anesthesia and Neurotoxicity Research
- Paraoxonase enzyme and polymorphisms
Sun Yat-sen University
2021-2025
Third Affiliated Hospital of Sun Yat-sen University
2025
China-Japan Friendship Hospital
2015-2024
Zhejiang A & F University
2023
Anhui University of Science and Technology
2021
Anhui Agricultural University
2021
Jiangmen Central Hospital
2021
Xuzhou Medical College
2021
Xuzhou Central Hospital
2021
Qilu Hospital of Shandong University
2021
Growing evidence suggests that symptoms associated with post-COVID-19 condition (also known as long COVID) can affect multiple organs and systems in the human body, but their association viral persistence is not clear. The aim of this study was to investigate SARS-CoV-2 diverse tissues at three timepoints following recovery from mild COVID-19, well its COVID symptoms.
Inflammation causes tissue damage and promotes ventricular remodeling after myocardial infarction (MI), the infiltration polarization of macrophages play an important role in regulating inflammation post-MI. Here, we investigated anti-inflammatory function curcumin MI studied its relationship with macrophage polarization. In vivo, not only attenuated 3 months but also suppressed during first 7 days Importantly, results qPCR immunochemistry showed that decreased M1 (iNOS, CCL2, CD86)...
Free fatty acids (FFA) is a key contributor to insulin resistance and endothelial dysfunction. However, the precise mechanism underlying role of FFA remains elusive. This study aimed investigate NLRP3 (NOD-like receptor pyrin domain containing-3) inflammasome in induced HUVECs were transfected with siRNA then stimulated LPS palmitate. C57 BL/6 J mice Lenti-Virus fed high-fat diet (HFD). The levels inflammasome, AMPKα (AMP-activated protein kinase), nitric oxide synthase (eNOS) activity...
Abstract Background Atherosclerotic plaque vulnerability is a key feature of atheroprogression and precipitating acute cardiovascular events. Although the pivotal role epigenetic regulation in atherosclerotic destabilization being recognized, DNA methylation profile its potential driving progression disease remains largely unknown. We conducted genome-wide analysis to identify differentially methylated genes vulnerable non-vulnerable lesions understand more about pathogenesis. Results...
Macrophage infiltration is a hallmark pathological change observed in early stage myocardial ischemia/reperfusion (MI/R) injury and one of the main causes damage. Here, we investigated effects p-Coumaric acid (p-CA) on macrophage polarization following MI/R its mechanisms.
Background: Atherosclerosis is closely associated with proliferation of the adventitial vasa vasorum, leading to atherosclerotic plaque progression and vulnerability. In this report, we investigated role Ginsenoside Rb 1 (Rb ) on stabilization vasorum (VV) along mechanisms involved. Methods Results: Apolipoprotein E-deficient (ApoE −/− mice were fed a high-fat diet for 20 weeks, then (50 mg/kg/d, intraperitoneal) was given 4 weeks. treatment significantly inhibited VV proliferation,...
Objectives Traumatic orbital apex syndrome (TOAS) is an uncommon but severe ocular complication of craniomaxillofacial fracture. The optimal surgical strategy for TOAS has not been determined. To investigate the endoscopic anatomy region, propose a protocol simultaneous endonasal decompression optic canal, superior fissure, and proper (EEDCFA) report its use in two patients. Methods An approach was utilized to dissect region silicon-injected adult cadaveric heads. details procedure used were...
Objective To investigate the protective effect of inhibition adenosine monophosphate activated protein kinase (AMPK) on blood brain barrier (BBB) and its mechanism in hypoxic/ischemic models. Methods Two hundred healthy male SD rats were randomly divided into sham-operated group, model group (ischemia 2 h-reperfusion 0, 24 72 h [I/R]), Compound C treated (giving intraperitoneal injection 20 mg/kg AMPK specific inhibitor C). Focal cerebral ischemia rat models established by occluding...
Background In recent years, the kidney function after Transcatheter Aortic Valve Replacement (TAVR) has gradually become a hot spot that arouse extensive attention.Our study is aimed to evaluate incidence and predictors of acute recovery (AKR) TAVR. Methods A total 102 patients undergoing TAVR in Beijing Anzhen Hospital from June 2021 March 2022 were enrolled our study. Patients divided into AKR group ( n = 54), unchanged 40) injury (AKI) 8) based on percent change estimated glomerular...
Abstract Background : Bacterial meningitis (BM) remains a devastating disease in children, and it causes substantial neurological morbidity mortality worldwide. However, there are few large-scale studies on the pathogens causing pediatric bacterial (PBM) their antimicrobial resistance (AMR) patterns China. The present multicenter survey summarized features of etiologies BM children characterized AMR patterns. Methods Data from 1193 cerebrospinal fluid isolates with who were admitted to 13...
Abstract Background : Bacterial meningitis (BM) remains a devastating disease among children and can cause substantial neurological morbidity mortality worldwide. However, there are limited large-scale data concerning the pathogens responsible for pediatric bacterial (PBM) their antimicrobial resistance (AMR) patterns in China. The objective of this multi-centre survey was tosummarize features etiologies causing BM to characterize AMR patterns. Methods Data 1193 cerebrospinal fluid isolates...
Background: Atherosclerotic plaque vulnerability is a key feature of atheroprogression and precipitating acute cardiovascular events. The DNA methylation profile its potential role in driving the progression destabilization atherosclerotic disease remains largely unknown. We conducted genome-wide analysis to identify differentially methylated genes vulnerable non-vulnerable lesions understand more about pathogenesis. Methods: Carotid artery plaques were obtained from patients with clinically...