A5101609298- Advanced Glycation End Products research
- Pancreatic function and diabetes
- Diabetes Management and Research
- Endoplasmic Reticulum Stress and Disease
- Diabetes and associated disorders
- Natural Antidiabetic Agents Studies
- Chronic Kidney Disease and Diabetes
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Diabetes Treatment and Management
- Calpain Protease Function and Regulation
- Cardiac and Coronary Surgery Techniques
- Angiogenesis and VEGF in Cancer
- Platelet Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cellular transport and secretion
- Antibiotics Pharmacokinetics and Efficacy
- Tissue Engineering and Regenerative Medicine
- Vascular Malformations and Hemangiomas
- Genomics, phytochemicals, and oxidative stress
- Pancreatic and Hepatic Oncology Research
- Metabolism, Diabetes, and Cancer
- Biochemical effects in animals
- Vanadium and Halogenation Chemistry
China-Japan Friendship Hospital
2009-2018
Sun Yat-sen University
2013
The evolution of Large Language Models (LLMs) like ChatGPT and GPT-4 has sparked discussions on the advent Artificial General Intelligence (AGI). However, replicating such advancements in open-source models been challenging. This paper introduces InternLM2, an LLM that outperforms its predecessors comprehensive evaluations across 6 dimensions 30 benchmarks, long-context modeling, open-ended subjective through innovative pre-training optimization techniques. process InternLM2 is meticulously...
Abstract Aims/Introduction Blockade or reversal the progression of diabetic nephropathy is a clinical challenge. The aim present study was to examine whether recombinant human glucagon‐like peptide‐1 (rh GLP ‐1) has an effect on alleviating urinary protein and albumin levels in rats. Materials Methods Streptozotocin‐induced diabetes rats were treated with rh ‐1 insulin saline. Using immunostaining, hematoxylin–eosin, electron microscopy periodic acid–Schiff staining pathology nephropathy, we...
Elevated extracellular free fatty acids (FFAs) can induce pancreatic beta cell apoptosis, thereby contributing to the pathogenesis of type 2 diabetes mellitus (T2D). Mitochondrial dysfunction has been implicated in FFA-induced apoptosis. However, molecular mechanisms linking mitochondrial and apoptosis are not clear. Dynamin-related protein 1 (DRP-1) is a fission modulator. In this study, we investigated its role INS-1 DRP-1 was promptly induced cells rat islets after stimulation by FFAs,...
Demyelination resulting from Schwann cell injury is a main pathological feature of diabetic neuropathy, and key contributor to this process may be inflammation due advanced glycation end products (AGEs). Therefore, protection by anti-inflammation agents anticipated. In study, we showed that interleukin-10 (IL-10), an anti-inflammatory cytokine, inhibits apoptosis cells induced AGEs in vitro. We isolated cultured rat sciatic nerves. As detected flow cytometry, markedly increased following...
Advanced glycation end products (AGEs) are believed to be involved in diverse complications of diabetes mellitus. Overexposure AGEs pancreatic β -cells leads decreased insulin secretion and cell apoptosis. Here, understand the cytotoxicity -cells, we used INS-1-3 cells as a -cell model address this question, which was subclone INS-1 exhibited high level expression sensitivity glucose stimulation. Exposed large dose AGEs, even though more synthesized, its significantly reduced from cells....
Diabetic nephropathy (DN) is a severe complication of diabetes mellitus (DM). Pancreas or islet transplantation has been reported to prevent the development DN lesions and ameliorate reverse existing glomerular in animal models. Shortage pancreas donor problem. Islets derived from stem cells may offer potential solution this To evaluate effect cell-derived on rat model streptozotocin-induced DM. Pancreatic progenitor were isolated aborted fetuses 8 weeks gestation. And islets prepared by...
Chronic exposure to free fatty acids (FFAs) may induce β cell apoptosis in type 2 diabetes. However, the precise mechanism by which FFAs trigger is still unclear. Tribbles homolog 3 (TRB3) a pseudokinase inhibiting Akt, key mediator of insulin signaling, and contributes resistance target tissues. This paper outlined role TRB3 FFAs-induced INS-1 apoptosis. was promptly induced cells after stimulation FFAs, this accompanied enhanced The overexpression led exacerbated triggered INS-1-derived...
The efficacy of gliquidone for the treatment diabetic nephropathy was investigated by implanting micro-osmotic pumps containing into abdominal cavities Goto-Kakizaki (GK) rats with nephropathy. Blood glucose, 24 h urinary protein, and albumin levels were measured weekly. After 4 weeks therapy, pathological changes in glomerular basement membrane (GBM) examined using an electron microscope. Real-time PCR, western blotting, immunohistochemistry employed to detect expression receptors advanced...
Advanced glycation end products (AGEs), which accumulate in the body during development of diabetes, may be one factors leading to pancreatic β-cell failure and reduced mass. However, mechanisms responsible for AGE‑induced apoptosis remain unclear. This study identified role action tribbles homolog 3 (TRB3) AGE-induced oxidative damage apoptosis. Rat insulinoma cells (INS-1) were treated with 200 µg/ml AGEs 48 h, cell was then detected by TUNEL staining flow cytometry. The level...
Microvasculopathy is the most serious and predictable threat to health of diabetic patients, which often results in end-stage renal disease, blindness, limb amputations. Up present, underlying mechanisms have remained elusive. Here, it was found that differential activations PKC/PKA were involved microvasculopathy GK rats. By real-time PCR, Western blot, immunohistochemistry, enzyme activity assay, upregulation PKC prominent kidney but not significant liver brain. The expression PKA lowered...
Leukocyte transendothelial migration and sequestration are two distinct outcomes following leukocyte adhesion to endothelium during ischemia-reperfusion injury, in which platelets may play a pivotal role. In the present study, we established an vitro hypoxia-reoxygenation model mimic injury found platelet pre-incubation significantly increased endothelial cells after hyoxia-reoxygenation (over 67%). Blockade of endothelial-cell-expressed molecules inhibited direct cells, while...
Aberrant blood vessel formation and hemorrhage may contribute to tumor progression are potential targets in the treatment of several types cancer. Pancreatic neuroendocrine tumors (PNETs) highly vascularized, particularly when they well‑differentiated. However, process vascularization endothelial cell detachment PNETs is poorly understood. In present study, 132 PNET clinical samples were examined a special type hemorrhagic region was observed ~30% regardless subtype. These regions presented...
The calcium-regulated transcription coactivator, Ca 2 + -responsive transactivator (CREST) was expressed in pancreatic β-cells. Moreover, CREST expression became significantly increased islets isolated from hyperglycemic Goto–Kakizaki rats compared with normoglycemic Wistar controls. In addition, culture of β-cells the presence high glucose concentrations also vitro . To further investigate role this regulation β-cell function, we established a stable line inducible expression. Hence,...