A5031768294- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Cancer Research and Treatments
- Cancer Cells and Metastasis
- Tryptophan and brain disorders
- Effects of Radiation Exposure
- Galectins and Cancer Biology
- HER2/EGFR in Cancer Research
- Gut microbiota and health
- Pharmacological Effects of Natural Compounds
- Rheumatoid Arthritis Research and Therapies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inflammasome and immune disorders
- Gout, Hyperuricemia, Uric Acid
- Cell Adhesion Molecules Research
- Toxin Mechanisms and Immunotoxins
- Signaling Pathways in Disease
- Healthcare and Venom Research
- Pancreatic and Hepatic Oncology Research
- Neuroscience and Neuropharmacology Research
- Traditional Chinese Medicine Analysis
- Immunotherapy and Immune Responses
- Cholinesterase and Neurodegenerative Diseases
Tianjin University of Traditional Chinese Medicine
2020-2024
Affiliated Hospital of Hangzhou Normal University
2021-2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2021-2024
Guangzhou University of Chinese Medicine
2019-2024
Heidelberg University
2024
University Hospital Heidelberg
2024
Ningxia Medical University General Hospital
2020-2024
Ningxia Medical University
2012-2024
Lanzhou University
2024
Guangdong Ocean University
2024
Myocardial fibrosis is a significant pathological basis of heart failure. Overactivation the ERK1/2 and JNK1/2 signaling pathways MAPK family members synergistically promotes proliferation myocardial fibroblasts accelerates development fibrosis. In addition to some small molecule inhibitors Western drugs, many Chinese medicines can also inhibit activity JNK1/2, thus slowing down fibrosis, are generally safe effective. However, specific biological mechanisms in still need be fully understood,...
Chronic heat stress can have detrimental effects on the survival of fish. This study aimed to investigate impact prolonged high temperatures growth, antioxidant capacity, apoptosis, and transcriptome analysis Hong Kong catfish (Clarias fuscus). By analyzing morphological statistics C. fuscus subjected chronic high-temperature for 30, 60, 90 days, it was observed that growth inhibited compared control group. The experimental group showed a significant decrease in body weight length after 60...
Cyclin B1, a key component in the control of cell cycle progression from G2 to M phase, has been implicated tumorigenesis and development malignancy. However, underlying mechanism by which cyclin B1 acts as an important oncogenic molecule remains largely unknown. Here we show that ectopic expression promotes proliferation, enhances motility migration results increased ability cells extravasating through capillary endothelium. Interestingly, isogenic esophageal squamous carcinoma (ESCC)...
Objectives This study aimed to investigate the association between microRNA-155 (miR-155) and severity extent of coronary stenotic lesions. Patients methods We measured miR-155 expression by real-time PCR in 110 consecutive patients undergoing angiography for suspected artery disease. The lesions were evaluated on basis findings Gensini score. Results was significantly lower 56 with heart disease than those 54 controls (P<0.01). level peripheral blood mononuclear cells or plasma unstable...
Maternal separation (MS), a stressful event in early life, has been linked to neuropsychiatric disorders later especially depression. In this study we investigated whether treatment with electroacupuncture (EA) could ameliorate depression-related manifestations adult animals that had adverse life experiences. We demonstrated depression-like behavior deficiencies sucrose preference test and forced swimming rat model neonatal maternal separation. Repeated EA at the acupoints Baihui (GV20)...
Early detection of liver metastasis is important for improving colorectal cancer (CRC) patient survival. Our previous studies showed haptoglobin was highly expressed in primary CRC tissues, especially heterochronous metastatic cases. Here, we assessed the potential serum (sHP) as a biomarker early by evaluating sHP 475 patients and 152 healthy volunteers. In training set (250 cases), level CRC-M1 (1773.18 ± 690.25 ng/mL) were significantly increased compared to CRC-M0 (1544.37 1497.65 or...
To explore the relationship between serum levels of inflammatory markers and symptomatic severity bipolar disorder (BD).A cross-sectional study was conducted on 126 BD patients with current depressive episode (BDD), 102 mixed or (hypo)manic (BDM) 94 healthy controls (HC). All participants were drug-naïve had no active physical illness associated response history substance abuse. Fasting CRP, leptin (LEP), adiponectin (ADP), visfatin (VIS), TNF-α, IL-2, IL-6, IL-10, IL-17), monocyte...
Abstract Purpose: The purpose of the present study was to screen autoantibody signature colon cancers develop serum markers for cancer detection. Experimental Design: A phage cDNA expression library built. sequentially screened by a pool 10 sera, goat antihuman IgG, and two healthy sera identify phage-expressed antigens recognized tumor-associated antibodies. clones picked out these screening were subjected training set with 24 sera. antigen combination, which got most satisfactory...
Background.Carboxypeptidase A4 (CPA4) belongs to a member of the metallocarboxypeptidase family, and its expression in lung cancer samples clinical significance are still not investigated until now.In this study, we aimed evaluate level CPA4 non-small-cell (NSCLC) correlate with outcome.Methods.CPA4 gene tissues were analyzed by using Oncomine database (www.oncomine.org).The CPA4, Survivin VEGF adjacent normal evaluated IHC corresponding primary antibodies on two different commercial tissue...
Bone marrow-mesenchymal stem cells (BM-MSCs) possess immunomodulatory properties in the brain. However, it remains unclear whether intravenously transplanted BM-MSCs have a neuromodulator effect on activation of microglias after ischemic stroke. This study aimed to investigate regulation brain microglial inactivation during acute phase A rat model middle cerebral artery occlusion (MCAO) was established. Rat were through tail vein at 12 h MCAO. CD200 Receptor 1 (CD200R1) antibody injected...