A5100612022- Healthcare and Venom Research
- Phytochemistry and Biological Activities
- High-Temperature Coating Behaviors
- High Entropy Alloys Studies
- Natural product bioactivities and synthesis
- Additive Manufacturing Materials and Processes
- Traditional Chinese Medicine Analysis
- Phytochemical and Pharmacological Studies
- Cytokine Signaling Pathways and Interactions
- Advanced Fiber Optic Sensors
- Computational Drug Discovery Methods
- Medicinal Plants and Bioactive Compounds
- Network Time Synchronization Technologies
- Heavy Metals in Plants
- Cancer-related molecular mechanisms research
- Cholinesterase and Neurodegenerative Diseases
- Real-Time Systems Scheduling
- Advanced MRI Techniques and Applications
- Artificial Intelligence in Healthcare and Education
- Flavonoids in Medical Research
- Pharmacological Effects and Toxicity Studies
- Barrier Structure and Function Studies
- Ethnobotanical and Medicinal Plants Studies
- Photodynamic Therapy Research Studies
- DNA Repair Mechanisms
Hangzhou Red Cross Hospital
2025
Huazhong University of Science and Technology
1997-2024
China-Japan Friendship Hospital
2010-2024
Guangzhou Medical University
2024
Kingmed Diagnostics
2024
Jiangxi Science and Technology Normal University
2010-2023
Jiangxi Transportation Research Institute
2022
Qingdao University of Technology
2022
Qingdao University of Science and Technology
2022
University of South China
2021
Abstract Sirtuins, which are NAD + -dependent class III histone deacetylases, involved in various biological processes, including DNA damage repair, immune inflammation, oxidative stress, mitochondrial homeostasis, autophagy, and apoptosis. Sirtuins essential regulators of cellular function organismal health. Increasing evidence suggests that the development age-related diseases, kidney is associated with aberrant expression sirtuins, regulation sirtuins activity can effectively improve...
Abstract In this study, we investigated the protective effects of a peptide ( YGDEY , Tyr‐Gly‐Asp‐Glu‐Tyr) isolated from tilapia skin gelatin hydrolysates TGH s), against UVB ‐induced photoaging in human keratinocytes (HaCaT) cells. Results showed that significantly decreased levels intracellular reactive oxygen species ROS ), increased antioxidant factors (Superoxide Dismutase, SOD and Glutathione, GSH ) expression maintained balance between GSSG HaCaT Comet assay shows can protect DNA...
As botanicals and dietary supplements are used increasingly in many countries, the issue of safety is particularly critical for regulation food products containing these substances. Seabuckthorn (Hippophae rhamnoides L.) has been centuries as a medicine nutritional supplement Asia Europe. However, data regarding to assessment plant its extracts still rare. This study was evaluate potential toxicity seabuckthorn berry (SB) oil conducted three genotoxicity studies teratogenicity study. Results...
The Ras signaling pathway is thought to control the expression of a subset yet be defined genes that are crucial for cell growth and differentiation. Here we have identified by differential display novel oncogenic target, mob-5, encoding 23-kDa cytokine-like secreted protein. Mob-5 could induced Ha-ras Ki-ras, but not normal ras activation. Inhibitors both Ha-Ras mitogen-activated protein kinase completely abolished mob-5 in transformed cells, with concomitant loss transformation phenotype....
In the process of extraction with hot water, many organic components in Radix scutellariae form complexes metal ions. Among them, baicalin–manganese has good antibacterial activity and less tendency to cause resistance.
Acetycholinesterase (AChE) that regulates hydrolysis of acetylcholine (ACh) in the brain, is an important target for treatment Alzheimer's disease (AD), a feature which ACh deficiency. However, methods to precisely determine AChE activity are still under development. We developed new method exploit acetylcholine-d4 as surrogate substrate and measure product choline-d4 via liquid chromatography-tandem mass spectrometry (LC-MS/MS). This assay detected present normal mouse consistent with...
Evaluating the association between a single nucleotide polymorphism in 3' untranslated region (3'UTR) of miRNA binding site
ChatGPT can improve Software Engineering (SE) research practices by offering efficient, accessible information analysis and synthesis based on natural language interactions. However, could bring ethical challenges, encompassing plagiarism, privacy, data security, the risk of generating biased or potentially detrimental data. This aims to fill given gap elaborating key elements: motivators, demotivators, principles using in SE research. To achieve this objective, we conducted a literature...
A simple, robust and specific liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed validated to determine the concentration of corticosterone (Cort) which is usually regarded as a stress biomarker in mouse serum. Since Cort an endogenous hormone, 'surrogate analyte' strategy adopted using stable isotope-deuterated surrogate authentic analyte generate calibration curve. With telmisartan internal standard, analytes were extracted with methanol, ethanol acetone (1:1:1,...
Rutin, a flavonoid commonly present in natural plants, can form multiple complexes at different rutin : metal ratios with various trace elements during the water decoction process, and these exhibit novel activities.
The discovery of organic components with pharmacological activities in medicinal plants is crucial for new drug development. We examined chlorogenic acid (CGA) using high-performance liquid chromatography to analyze the aqueous and methanolic extracts dissolved methanol or containing 15% formic acid. found that extract, peak areas various were significantly larger than those methanol. For differences all chromatographic peaks relatively small between samples two solvents. Electrospray...
Smart substations are an important trend in substation construction. With increasing data traffic, it is difficult for the traditional Ethernet network to meet real-time requirements of control information smart substations. Hence, this paper, a deterministic architecture based on time-sensitive networks (TSN) has been developed order realize domain-wide time synchronization and efficient communication “three-layer two-network” model Furthermore, design scheme automation equipment TSN...