A5100681639- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Berberine and alkaloids research
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- Cancer Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- RNA modifications and cancer
- Trace Elements in Health
- Advanced Radiotherapy Techniques
- Bone health and treatments
- Cancer, Hypoxia, and Metabolism
- interferon and immune responses
- Plant-based Medicinal Research
- Sulfur Compounds in Biology
- Alzheimer's disease research and treatments
- Inflammatory Biomarkers in Disease Prognosis
- MicroRNA in disease regulation
- Advancements in Photolithography Techniques
- Colorectal Cancer Treatments and Studies
- Environmental and Agricultural Sciences
- Renal cell carcinoma treatment
- Cancer therapeutics and mechanisms
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
West China Medical Center of Sichuan University
2025
Fujian Normal University
2023-2024
Zhongshan Hospital
2012-2024
Fudan University
2014-2024
Ningxia Medical University General Hospital
2024
Ningxia Medical University
2013-2024
Sun Yat-sen University
2011-2024
The First Affiliated Hospital, Sun Yat-sen University
2008-2024
South China University of Technology
2009-2024
Donafenib, a novel multikinase inhibitor and deuterated sorafenib derivative, has shown efficacy in phase Ia Ib hepatocellular carcinoma (HCC) studies. This study compared the safety of donafenib versus as first-line therapy for advanced HCC.This open-label, randomized, parallel-controlled, multicenter II-III trial enrolled patients with unresectable or metastatic HCC, Child-Pugh score ≤ 7, no prior systemic from 37 sites across China. Patients were randomly assigned (1:1) to receive oral...
// Ping Song 1, * , Li Ye Jiajun Fan 1 Yubin Xian Zeng Ziyu Wang Shaofei Guoping Zhang 2 Yang 3 Zhonglian Cao Dianwen Ju Department of Biosynthesis & The Key Laboratory Smart Drug Delivery, Ministry Education, School Pharmacy, Fudan University, Shanghai, 201203, P.R. China Institute Biomedical Science, 200032, Instrumental Analysis Center, These authors have contributed equally to this work Correspondence to: Ju, e-mail: dianwenju@fudan.edu.cn Keywords: asparaginase, autophagy,...
Studies of the gut–liver axis have enhanced our understanding pathophysiology various liver diseases and mechanisms underlying regulation effectiveness therapies. Radiotherapy (RT) is an important therapeutic option for patients with unresectable hepatocellular carcinoma (HCC). However, role microbiome in regulating response to RT remains unclear. The present study characterizes gut responsive or non-responsive investigates molecular differences patient response. We collected fecal samples...
The current study was performed to identify clinical features and independent predictors of survival in patients with bone metastases from hepatocellular carcinoma (HCC).Patients (n = 205) HCC received external beam radiotherapy (EBRT) between 1997 2007. Demographic variables, laboratory values, tumor characteristics, treatment modalities were determined before EBRT. total radiation dose ranged 32 66 grays (Gy) (median, 50 Gy) focused on the involved bone.In 80 205 (39.0%) metastasis HCC,...
Phyllodes tumor of the prostate is a rare neoplasm uncertain malignant potential. We studied large series phyllodes tumors to define combination histological features that are most useful for predicting patient outcome.A total 23 cases were obtained from our collective files 1973 2002, and numerous clinical pathological evaluated. A review reported was done.Patient age 25 86 years (mean 55) they usually presented with urinary obstructive symptoms hematuria. The diagnosis made in 18 by...
Abstract In this study, we investigated the protective effects of a peptide ( YGDEY , Tyr‐Gly‐Asp‐Glu‐Tyr) isolated from tilapia skin gelatin hydrolysates TGH s), against UVB ‐induced photoaging in human keratinocytes (HaCaT) cells. Results showed that significantly decreased levels intracellular reactive oxygen species ROS ), increased antioxidant factors (Superoxide Dismutase, SOD and Glutathione, GSH ) expression maintained balance between GSSG HaCaT Comet assay shows can protect DNA...
The effectiveness of several zeolite catalysts was investigated using the cataluminescence (CTL) gas sensor system. Trace amounts n-hexane in air samples were detected by this method. This research establishes that specific pore size offers designable environment for selective CTL reaction, and "Lewis-type" basic sites appear to contribute catalytic nature surface. By incorporating either Cs+ or K+, velocity luminescence intensity these reactions increase while going from Na Cs, according...
Licorice is an herb extensively used for both culinary and medicinal purposes. Various constituents of licorice have been shown to exhibit anti-tumorigenic effect in diverse cancer types. However, majority these studies focus on the aspect their growth-suppressive role. In this study, we systematically analyzed known licorice's goal identifying component(s) that can effectively suppress cell migration growth. Effect growth was evaluated by MTT assay while assessed wound-healing Transwell...
Abstract PANoptosis plays a crucial role in cancer initiation and progression. However, the roles of PANoptosis-related genes (PARGs) prognosis immune landscape head neck squamous cell carcinoma (HNSCC) remain unclear. Integrated bioinformatics analyses based on data HNSCC patients TCGA database were conducted. We extracted 48 PARGs expression profile then conducted differentially expressed analysis, following building Cox model to predict survival patients. Subsequently, relationships...
To compare the efficacies of conventional three-dimensional conformal radiotherapy and image-guided hypofractionated intensity-modulated treatments in advanced hepatocellular carcinoma patients with portal vein and/or inferior vena cava tumor thrombi. A total 118 thrombi who received external beam radiation therapy focused on intrahepatic tumors were retrospectively reviewed. During treatments, a median dose 54 Gy fraction (1.8–2.0 Gy/fx) was delivered. 60 fractions 2.5−4.0 Gy/fx The...
Quantum dots (QDs) were reported to be metabolized by the liver and demonstrated toxic in vitro vivo with unclear mechanisms, which largely limited their applications field of biomedical research. To improve biosafety, mechanism how QDs triggered hepatotoxicity was evaluated this study. We found that CdTe/CdS can trigger significant apoptosis-independent nanotoxicity after uptake cells internalization into lysosomes. Besides, lysosomal enzymes abnormally activated entered lysosomes, caused...
Simulation-based medical education (SBME) and three-dimensional printed (3DP) models are increasingly used in continuing clinical training. However, our understanding of their role value improving trainees' the anatomical surgical procedures associated with liver surgery remains limited. Furthermore, gender bias is also a potential factor evaluation education. Therefore, aim this study was to evaluate educational benefits trainees receive from use novel 3DP while considering experience...
Accurate prediction of prognosis and postoperative radiotherapy response is critical for personalized treatment in head neck squamous cell carcinoma (HNSCC). We developed a multimodal deep learning model (MDLM) integrating computed tomography, whole-slide images, clinical features from 1087 HNSCC patients across multiple centers. The MDLM exhibited good performance predicting overall survival (OS) disease-free external test cohorts. Additionally, the outperformed unimodal models. Patients...
Abstract Introduction Plants in the genus Stephania can produce diverse bioactive alkaloids. hainanensis is a medicinal plant that contains effective However, only 10 alkaloids have been reported this species. Objective To characterise using liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry (LC‐QTOF‐MS/MS). Methods An LC‐QTOF‐MS/MS method was developed for structural characterisation of . The chromatographic separation performed on phenyl column gradient...
Cardiopulmonary bypass (CPB) is associated with activation of pro-inflammatory cells, which infiltrate tissues and cause injury. Here we explored a novel disposable remover to remove inflammatory leukocytes in order reduce risk complications after CPB. This substudy within previously registered clinical trial (NCT05400356) that aims validate activated generated during The device contains an enhanced biocompatible leukocyte membrane (Chinese patent CN202310822538.X) coated RGD peptide...
CuCl has been successfully immobilized on a novel diamide modified SBA-15, and proven to be an efficient heterogenized catalyst for the oxidative carbonylation of methanol dimethylcarbonate.
The optimal treatment for adrenal metastases from hepatocellular carcinoma (HCC) has not been established. This study analyzed the effects of radiation therapy (RT) such and identified clinical features predictors survival in these patients. We retrospectively investigated 55 patients with metastasis HCC who had treated RT. Radiation doses to lesions ranged 26 60 Gy, while intrahepatic were by surgical resection, transarterial chemoembolization (TACE), liver transplantation, and/or RT was...
// Zuo-Lin Xiang 1, * , Xiao-Mei Zhao Li Zhang 1 Ping Yang Jia Fan 2 Zhao-You Tang Zhao-Chong Zeng Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China Liver Cancer Institute, These authors have contributed equally to this work Correspondence to: Zeng, email: zeng.zhaochong@zs-hospital.sh.cn Keywords: hepatocellular carcinoma, bone metastasis, microRNA-34a, serum, tissue microarray Received: July 05, 2016 Accepted: November 07, Published: 23, ABSTRACT...
Asparaginase has been reported to be effective in the treatment of various leukemia and several malignant solid cancers. However, anti-tumor effect asparaginase is always restricted due complicated mechanisms. Herein, we investigated mechanisms how glioblastoma resisted a novel approach enhance anti-glioblastoma asparaginase. We found that could induce growth inhibition caspase-dependent apoptosis U87MG/U251MG cells. Meanwhile, autophagy was activated as indicated by autophagosomes formation...
The tuberous roots of Stephania kwangsiensis, which contain bioactive alkaloids, are used as a traditional Chinese medicine. Overexploitation the has made plant increasingly rare, and abundant leaves same may offer potential alternative. However, there is insufficient phytochemical information for comparison alkaloid compositions in two parts.To characterise compare alkaloids S. kwangsiensis.The kwangsiensis were characterised using high pressure liquid chromatography coupled with positive...