A5101558825- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Pulmonary Hypertension Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Lower Extremity Biomechanics and Pathologies
- Amoebic Infections and Treatments
- interferon and immune responses
- Systemic Lupus Erythematosus Research
- Drug-Induced Hepatotoxicity and Protection
- Advanced Fiber Optic Sensors
- Liver physiology and pathology
- MicroRNA in disease regulation
- Pleural and Pulmonary Diseases
- Orthopaedic implants and arthroplasty
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Cancer Mechanisms and Therapy
- Muscle and Compartmental Disorders
- Ultrasound in Clinical Applications
- Extracellular vesicles in disease
Sun Yat-sen University
2025
Third Affiliated Hospital of Sun Yat-sen University
2025
Jilin University
2013-2024
First Hospital of Jilin University
2013-2024
Chengdu Medical College
2024
Anhui University of Finance and Economics
2023
Affiliated Hospital of Guilin Medical College
2023
Guangxi University of Chinese Medicine
2022
Creative Commons
2022
Guangxi University
2022
Donafenib, a novel multikinase inhibitor and deuterated sorafenib derivative, has shown efficacy in phase Ia Ib hepatocellular carcinoma (HCC) studies. This study compared the safety of donafenib versus as first-line therapy for advanced HCC.This open-label, randomized, parallel-controlled, multicenter II-III trial enrolled patients with unresectable or metastatic HCC, Child-Pugh score ≤ 7, no prior systemic from 37 sites across China. Patients were randomly assigned (1:1) to receive oral...
ABSTRACT Hepatitis C virus (HCV) infection induces a wide range of chronic liver injuries; however, the mechanism through which HCV evades immune surveillance system remains obscure. Blood dendritic cells (DCs) play pivotal role in recognition viral and induction innate adaptive responses. Several reports suggest that dysfunction DCs patients with hepatitis C. Toll-like receptor (TLR) has been shown to various roles many infections; involvement proteins TLR signaling pathway not yet...
Abstract Background: The risk of HCC recurrence after liver resection or ablation with curative intent is 70-80% within 5 years, indicating an unmet need for effective adjuvant therapies. Atezolizumab (atezo) bevacizumab (bev) the standard care unresectable based on IMbrave150 study, which demonstrated statistically significant and clinically meaningful improvements in overall survival (OS), progression-free survival, objective response rate versus sorafenib (Finn NEJM 2020, Cheng J Hepatol...
Objective To compare the effects of four intermittent fasting regimens on blood glucose and insulin sensitivity in people with type 2 diabetes. Methods Randomized controlled trials treatment patients diabetes mellitus PubMed, Cochrane Library, Embase, ScienceDirect, Web Science, CNKI, VIP Database, WANFANG Database were searched for from library to September 2023. review authors independently screened studies extracted data. RevMan 5.4 was used direct comparison meta-results. Network...
Abstract Palbociclib, a CDK4/6 inhibitor, plays crucial role in the treatment of HR+ breast cancer. However, resistance to palbociclib is significant concern that merits further investigation. Our investigation identifies TMEM45A as potential driver and its association with increased cellular glycolysis. We demonstrate highly expressed palbociclib-resistant cancer (BRCA) cells, correlating enhanced tumor progression. Silencing enhances sensitivity palbociclib, promotes cell cycle arrest...
Autographa californica nuclear polyhedrosis virus (AcNPV) is a double-stranded-DNA that pathogenic to insects. AcNPV was shown induce an innate immune response in mammalian cells and confer protection of mice from lethal viral infection. In this study, we have production type I interferon (IFN) by murine plasmacytoid dendritic (pDCs) non-pDCs, such as peritoneal macrophages splenic CD11c+ DCs, mediated Toll-like receptor (TLR)-dependent -independent pathways, respectively. IFN regulatory...
Primary liver cancer is the third most common malignancy, and hepatocellular carcinoma its main subtype, with a high recurrence rate mortality. Intestinal microflora metabolic disorders are present in HCC patients. Traditional Chinese medicine (TCM) plays an important role composition of intestinal microorganisms transformation active metabolites. Many scholars trying to develop related drugs assist treatment cancer. In preliminary study research group, it was found that Jiawei Xiaoyao San...
Recently, there is ample evidence suggesting the important role of microRNAs (miRNAs) in autoimmune diseases via modulating B cells function. Primary biliary cholangitis (PBC) a progressive immune-mediated liver disease with unclear pathogenic mechanism. Whether miRNA peripheral PBC involve mechanisms pathology and progression not known. The present study explores deregulation B-cell from stage I to IV healthy controls. Peripheral were obtained 72 patients (stage I, n = 17; II, 23; III, 16;...
There are few studies on the prevalence and clinical characteristics of portopulmonary hypertension (POPH) in patients with portal hypertension. In addition, invasive right heart catheterization further limits diagnosis POPH patients.From January 2018 to December 2019, 1004 were treated Department Hepatology, First Hospital Jilin University. Based inclusion exclusion criteria, 188 finally included. We collected complete data, laboratory examinations, imaging examinations. Patients divided...
In Brief Study Design. Case report. Objective. We report a rare case that ganglion cyst compressed the sciatic nerve and caused sciatica claudication in 51-year-old male. Summary of Background Data. Sciatica commonly occurs spinal stenosis. To our knowledge, only 4 cases have been reported on resulting from posterior hip. Methods. A male had 2-month history radiating pain his right leg. He could walk 20 to 30 m before stopping standing rest for 1 3 minutes. Interestingly, he was able longer...
Hepatitis B virus (HBV) causes hepatitis (HB) and distinct HBV genotypes can lead to different prognoses. However, genotyping is rarely done in clinics, because the traditional method by PCR-based DNA sequencing impractical for clinical diagnosis with tedious process low success rate. Herein, we have established an ELISA-based quickly determine of HB patients China. First, two commercial antibodies, 16D12 6H3 specific C respectively, are chosen as capture since these dominate Then home-made...
Madelung disease (MD), a rarely reported disease, also known as benign symmetric lipomatosis, disorder resulting from alcoholic abuse. It's largely under-recognized and under-reported, possibly because of unawareness the condition by physicians.A 45-year-old Chinese man presented with intermittent fatigue abdominal distension progressive bilateral breast enlargement. He has been heavy drinker for ten years before onset an average daily alcohol intake more than 120 g/day.Due to patient's...
Background and aims Hepatic Hydrothorax (HH) is one of the complications in patients with decompensated cirrhosis its impact role prognosis are not yet clear. Thus, this study aimed to determine HH long-term on their mortality. Materials methods A retrospective analyzed 624 ascites without pleural effusion 113 HH. Propensity scores were calculated based eight variables, non-HH groups matched a 1:1 ratio. The effect was using Kaplan–Meier method Cox proportional hazards regression model....
To eliminate hepatitis C virus (HCV) from infected hepatocytes, we generated two therapeutic molecules specifically activated in cells with HCV. A dominant active mutant of interferon (IFN) regulatory factor 7 (IRF7) and a negative regulator HCV replication, VAP-C (Vesicle-associated membrane protein-associated protein subtype C), were fused the C-terminal region IPS-1 (IFNβ promoter stimulator-1), which includes an protease cleavage site that was modified to be localized on ER membrane,...
Abstract Background Whether the posterior tibial slope (PTS) is associated with femoral condylar shape has remained unclear. Classical anatomical studies considered sagittal profiles of condyles to consist two circles. Recently, an elliptical method was described simplify “two circles” model. Our purpose analyze relationship between PTS and condyle, that is, circles ellipses, using magnetic resonance imaging (MRI) scans. Methods Eighty right knees healthy subjects were scanned by MRI at full...
The clinical features and factors affecting the prognostic survival of hepatic hydrothorax (HH) are currently unknown.
Abstract Rationale: Drug-induced liver injury (DILI) has a relatively low incidence, whereas the incidence of herb-induced (HILI) is still under investigation. As special type DILI, diagnosis drug-induced autoimmune-like hepatitis presents persistent challenge, because this condition partial characteristics both DILI and autoimmune (AIH), such as certain history medication use histology that similar to AIH. Thus, differential between AIH can be confusing. Patient concerns: A 67-year-old...