Zdeněk Král
A5032446221- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- CNS Lymphoma Diagnosis and Treatment
- Histiocytic Disorders and Treatments
- Viral-associated cancers and disorders
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Multiple and Secondary Primary Cancers
- Cancer Treatment and Pharmacology
- Eosinophilic Disorders and Syndromes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Reproductive Biology and Fertility
- Cancer Risks and Factors
- Myasthenia Gravis and Thymoma
- Bone health and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Immunodeficiency and Autoimmune Disorders
- IgG4-Related and Inflammatory Diseases
- Photonic Crystals and Applications
- Vascular Malformations and Hemangiomas
- Chemotherapy-induced cardiotoxicity and mitigation
- Inflammatory Myopathies and Dermatomyositis
Masaryk University
2009-2024
University Hospital Brno
2012-2024
Charles University
2007-2024
Ocní klinika
2000-2023
A. Alikhanyan National Laboratory
2023
University of Aveiro
2018-2023
Národný Onkologický Ústav
2021-2022
Zbrojovka Vsetín (Czechia)
2021
Thermo Fisher Scientific (United States)
2018-2020
Czech Technical University in Prague
2014-2018
Whether it is possible to reduce the intensity of treatment in early (stage I or II) Hodgkin's lymphoma with a favorable prognosis remains unclear. We therefore conducted multicenter, randomized trial comparing four groups consisting combination chemotherapy regimen two different intensities followed by involved-field radiation therapy at dose levels.We randomly assigned 1370 patients newly diagnosed early-stage one groups: cycles doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD)...
In patients with early unfavorable Hodgkin's lymphoma (HL), combined modality treatment four cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) 30 Gy involved-field radiotherapy (IFRT) results in long-term tumor control approximately 80%. We aimed to improve these using more intensive chemotherapy.Patients newly diagnosed HL were randomly assigned either or an intensified consisting two escalated BEACOPP (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine,...
This retrospective study evaluated the secondary clinical risk score at relapse, prognostic significance of pre-transplant positron emission tomography (PET), and complete remission (CR) assessed by computed (CT) after salvage chemotherapy before autologous stem cell transplant (ASCT) in 76 patients with relapsed/refractory Hodgkin lymphoma (HL). Median follow-up ASCT was 23 months. Overall 11/20 PET-positive 14/56 PET-negative relapsed ASCT. In univariate analysis, only PET negativity...
This work presents the fabrication and gas sensing properties of Love wave sensors based on non-modified gold nanoparticle-modified polypyrrole. Results demonstrate integration uniform polypyrrole layers with smooth granular surface incorporation dispersed crystalline nanoparticles within modified layers. Gas tests in dry conditions show enhanced performance to ethylene ammonia for systems as compared those without modification reported literature. The effect humidity proves significant both...
BACKGROUND: Frequent negative consequence of chemotherapy (CHT) is ovarian damage and premature failure (POF).Aim this prospective case -control study evaluation GnRH analogue (GnRH-a) administration to patients with Hodgkin lymphoma (HL) during CHT prevention depending upon regimen.METHODS: Study group consists 72 in fertile age (18-35 years) HL diagnosis treated 2004-2005 by curative together (Triptorelin) according a standardized protocol.Patients were divided into three groups the stage...
The COMPASS experiment recently discovered a new isovector resonance-like signal with axial-vector quantum numbers, the $a_1(1420)$, decaying to $f_0(980)\pi$. With mass too close and width smaller than ground state $a_1(1260)$, it was immediately interpreted as light exotic meson, similar $X$, $Y$, $Z$ states in hidden-charm sector. We show that fully matching experimental data is produced by decay of $a_1(1260)$ resonance into $K^\ast(\to K\pi)\bar{K}$ subsequent rescattering through...
We study the spin-exotic $J^{PC} = 1^{-+}$ amplitude in single-diffractive dissociation of 190 GeV$/c$ pions into $\pi^-\pi^-\pi^+$ using a hydrogen target and confirm $\pi_1(1600) \to \rho(770) \pi$ amplitude, which interferes with nonresonant $1^{-+}$ amplitude. demonstrate that conflicting conclusions from previous studies on these amplitudes can be attributed to different analysis models treatment dependence squared four-momentum transfer we thus reconcile their experimental findings....
We report on a measurement of hard exclusive $\pi^0$ muoproduction the proton by COMPASS using 160 GeV/$c$ polarised $\mu^+$ and $\mu^-$ beams CERN SPS impinging liquid hydrogen target. From average measured cross sections, virtual-photon section is determined as function squared four-momentum transfer between initial final in range $0.08\,(\text{GeV/}c)^2 < |t| 0.64\,(\text{GeV/}c)^2$. The kinematics are $\langle Q^2 \rangle =2.0\; {(\text{GeV}/c)^2}$, \nu = 12.8\; {\text{GeV}}$, x_{Bj}...
The present study assessed several parameters of cardiopulmonary function in patients, after treatment for aggressive non-Hodgkin's lymphoma and Hodgkin's disease, to determine the influence these on patient's performance status. One hundred six patients (66 male 40 female) aged ± 15 years were examined 1–2 (median 14 months) anticancer treatment. by means rest dynamic stress echocardiography exercise. post-exercise ejection fraction (EF), Doppler left ventricular diastolic peak oxygen...
The international, randomized phase 3 HD15 trial established 6xeBEACOPP as standard therapy for patients with newly diagnosed advanced-stage Hodgkin lymphoma (HL) within the German Study Group (GHSG). We performed a follow-up analysis to assess long-term efficacy and safety of this approach. Between 2003 2008, 2182 aged 18 60 years were recruited in 1:1:1 ratio between 8 or 6 cycles eBEACOPP dose-dense BEACOPP-14 regimen, each followed by 30 Gy radiotherapy case positron emission tomography...
The transverse spin asymmetries measured in semi-inclusive leptoproduction of hadrons, when weighted with the hadron momentum $P_T$, allow for extraction important transverse-momentum-dependent distribution functions. In particular, Sivers provide direct information on function, which is a leading-twist that arises from correlation between an unpolarised quark transversely polarised nucleon and nucleon. Using high-statistics data collected by COMPASS Collaboration 2010 proton target, we have...
The production of vector mesons in deep inelastic scattering is an interesting yet scarsely explored channel to study the transverse spin structure nucleon and related phenomena. COMPASS collaboration has performed first measurement Collins Sivers asymmetries for inclusively produced $\rho^0$ mesons. analysis based on data set collected $2010$ using a $160\,\,\rm{GeV}/c$ $\mu^+$ beam impinging transversely polarized $\rm{NH}_3$ target. $\rho^{0}$ are selected from oppositely charged hadron...