Abstract Cervical cancer continues to be among the most frequent gynaecologic cancers worldwide. The phosphoinositide 3‐kinase ( PI 3K)/protein kinase B AKT ) pathway is constitutively activated in cervical cancer. Inositol polyphosphate 4‐phosphatase type II INPP 4B) a phosphatase and considered negative regulatory factor of 3K/ pathway. 4B has diverse roles various tumours, but its role largely unknown. In this study, we investigated Overexpression HeLa, SiHa C33a cells inhibited cell...

Abstract Regulator of chromatin condensation 1 (RCC1) is a major guanine-nucleotide exchange factor for Ran GTPase and plays key roles in nucleo-cytoplasmic transport, mitosis, nuclear envelope assembly. RCC1 known to be critical cell cycle regulator whose loss causes G1 phase arrest, but the molecular basis this regulation poorly understood. Furthermore, little about relationship between carcinomas. Human papillomavirus (HPV) infection highly associated with development cervical cancer. The...

Osteosarcomas (OS) are highly metastatic and usually lead to poor outcomes. Epithelial-mesenchymal transition (EMT) is reported be a critical event in metastasis. SIRT2 exerts dual functions many different tumors. However, the underlying molecular mechanisms of osteosarcoma cell metastasis question whether regulates EMT have not been fully explored. In this study, we confirmed that was highly-expressed human MG63 Saos-2 lines. The viability, migration invasion cells were inhibited by...

Background: Radiotherapy (RT) may trigger systemic antitumor immunity, manifesting as regression of non-irradiated lesions (abscopal effect).Intracellular adhesion molecule-1 (ICAM-1) is a key molecule involved in the abscopal effect RT.However, specific function ICAM-1 CD8 + T cells during immune responses remains unclear.Herein, we investigated whether noninvasive imaging can be used to annotate T-cell function, thereby better selecting combinational therapy enhance immunity induced by...

Persistent infection with high-risk human papillomavirus (HPV) is the main risk factor for cervical cancer.Our mass spectrometry data showed that Ras-associated binding protein Rab31 was upregulated by HPV; however, little known regarding role of in metastasis cancer cells.In this study, we highly expressed tissues and cells, both HPV E6 E7 promoted expression Rab31.Rab31 knockdown inhibited while overexpression migration invasion capabilities cells.Additionally, epithelial-mesenchymal...

<title>Abstract</title> <bold>Objective</bold> To describe the imaging features of osteonecrosis femoral head (ONFH) on fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT and explore value PET/CT in assessing ONFH patients with lymphoma.<bold>Methods</bold> A retrospective analysis was conducted clinical data, PET/CT, MRI manifestations 17 lymphoma. The FDG uptake recorded, maximum standardized (SUV_max) measured. staging extent ONFH, other bone involvements, were...

ABSTRACT Specific types of human papillomavirus (HPV) are strongly associated with the development cervical carcinoma. The HPV E6 oncoprotein from degrades p53 and abrogates cell cycle checkpoints. Nonetheless, functional has been observed in cancer. We have previously identified a p53-independent function attenuating postmitotic G 1 -like checkpoint that can lead to polyploidy, an early event during carcinogenesis predisposes cells aneuploidy. How promotes progression presence its target,...

Persistent infection of high-risk human papillomavirus (HPV) and the expression E6 E7 oncoproteins are main causes cervical cancer. Several prophylactic HPV vaccines used in clinic, but these have limited efficacy patients already infected with HPV. Since is vital for tumor-specific immunity, developing a vaccine against an attractive strategy cancer treatment. Here, we constructed HPV16 mutant that loses ability to bind pRb while still eliciting robust immune response. In order build...

Abstract STING-mediated DNA sensing pathway plays a crucial role in the innate antiviral immune responses. Clarifying its regulatory mechanism and searching STING agonists has potential clinical implications. Although multiple have been developed to target cancer, there are few for treatment of infectious diseases. Astaxanthin, natural powerful antioxidant, serves many biological functions as candidate drug However, how astaxanthin combats viruses whether regulates cyclic GMP-AMP...

Stimulator of interferon genes (STING) is vital in the cytosolic DNA-sensing process and critical for initiating innate immune response, which has important functions host defense contributes to pathogenesis inflammatory diseases. Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) specifically binds CpG dinucleotides viral RNAs multiple viruses promotes their degradation. ZAPS (ZC3HAV1 short isoform) a potent stimulator retinoid acid-inducible gene I (RIG-I) signaling during response....

// Weifang Zhang 1 , Hanxiang Chen Yan Juan Liu Xiao Wang 2 Xiuping Yu Jason J. 3, 4 Weiming Zhao Institute of Pathogenic Biology, Shandong University School Medicine, Jinan, Shandong, China Pathophysiology, 3 Department Massachusetts Medical School, Worcester, MA, USA Cancer Research Center, Correspondence to: Zhang, e-mail: zhangweifang@sdu.edu.cn Zhao, zhaowm@sdu.edu.cn Keywords: CIP2A, HPV, E7, G1 arrest, E2F1 Received: August 12, 2014 Accepted: December 07, Published: February 04, 2015...

General control nondepressible 5 (GCN5), the first identified transcription-related lysine acetyltransferase (KAT), is an important catalytic component of a transcriptional regulatory SAGA (Spt-Ada-GCN5-Acetyltransferase) and ATAC (ADA2A-containing) complex. While GCN5 has been implicated in cancer development, its role cervical not known. The human papillomavirus (HPV) oncoprotein E7 abrogates G1 cell cycle checkpoint induces genomic instability, which plays central carcinogenesis. In this...

The high-risk human papillomavirus (HPV) is the causative agent for cervical cancer. HPV E7 oncogene promotes S-phase entry from quiescent state in presence of elevated cell cycle inhibitor p27Kip1, a function that may contribute to carcinogenesis. However, mechanism by which induces cells into not fully understood. Interestingly, we found Dyrk1B, dual-specificity kinase and negative regulator proliferation cells, was upregulated expressing cells. Surprisingly contrast what previously...

Abstract Infection with high‐risk human papillomaviruses (HR‐HPVs, including HPV‐16, HPV‐18, HPV‐31) plays a central aetiologic role in the development of cervical carcinoma. The transforming properties HR‐HPVs mainly reside viral oncoproteins E6 and E7. protein degrades tumour suppressor p53 abrogates cell cycle checkpoints. Cancerous inhibitor phosphatase 2A (CIP2A) is an oncoprotein that involved carcinogenesis many malignancies. Our previous data showed CIP2A was overexpressed cancer....

Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a recently identified oncoprotein. Here, we investigated its role in the formation multidrug resistance (MDR) cervical adenocarcinoma vitro and vivo. MTT assay showed that knockdown CIP2A expression increased drug sensitivity HeLa Dox-resistant cells (HeLa-Dox) to doxorubicin, cisplatin, paclitaxel significantly, while overexpression decreased chemo-drugs dramatically. When treated with different chemotherapeutics, P-glycoprotein...

The human papillomavirus (HPV) plays a central role in cervical carcinogenesis and its oncogene E7 is essential this process. We showed here that abrogated the G1 cell cycle checkpoint under hypoxia analyzed key related proteins for their potential To further explore mechanism by which bypasses hypoxia-induced arrest, we applied proteomic approach used mass spectrometry to search are differentially expressed expressing cells hypoxia. Among identified, Cdc6 DNA replication initiation factor...

Abstract A 66-year-old man with gastric signet-ring cell carcinoma underwent both 18 F-FDG and FAl-NOTA-FAPI PET/CT imaging. There was no abnormal FDG activity in the stomach, but there diffuse intense uptake known lesion an adjacent metastasis.

HPV-positive (HPV+) cervical cancer cells are more radioresistant compared with HPV-negative (HPV-) cells, but the underlying mechanism is not fully illuminated. Our previous mass spectrometry data showed that Ras-associated binding protein Rab12 was up-regulated by HPV, and this study to investigate role of in radioresistance cells. CCK-8 assay, colony formation flow cytometry, Western blot were performed determine cell proliferation, apoptosis, cycle distribution, expressions. DNA damage...

Clinical trials have shown that trastuzumab (H) and pertuzumab (P) combined with chemotherapy as neoadjuvant therapy increased pathological complete response (pCR) rate of patients human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, date in China the real world are currently limited. data from HER2-positive cancer who received HP at institutions March 2019 to February 2022 were retrospectively analyzed. Adverse reactions evaluated using CTCAE version 5.0. The...