A5100458359- Cancer Immunotherapy and Biomarkers
- Neonatal Respiratory Health Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Tracheal and airway disorders
- Occupational and environmental lung diseases
- Photodynamic Therapy Research Studies
- Gastric Cancer Management and Outcomes
- Chemokine receptors and signaling
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Pulmonary Hypertension Research and Treatments
- Nanoplatforms for cancer theranostics
- Congenital Diaphragmatic Hernia Studies
- CAR-T cell therapy research
- Endoplasmic Reticulum Stress and Disease
- Bone Metabolism and Diseases
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Cervical Cancer and HPV Research
- Metal complexes synthesis and properties
- Cancer Mechanisms and Therapy
Anhui Medical University
2005-2025
First Affiliated Hospital of Anhui Medical University
2025
Zhangzhou Vocational and Technical College
2025
Second Affiliated Hospital of Zhejiang University
2021-2025
Taizhou University
2024-2025
Chinese People's Liberation Army
2025
Chinese PLA General Hospital
2025
The First People's Hospital of Wenling
2025
Peking University
2015-2024
Peking Union Medical College Hospital
2015-2024
Irreversible destruction of bronchi and alveoli can lead to multiple incurable lung diseases. Identifying stem/progenitor cells with regenerative capacity utilizing them reconstruct functional tissue is one the biggest hopes reverse damage cure such Here we showed that a rare population SOX9+ basal (BCs) located at airway epithelium rugae regenerate adult human lung. Human BCs be readily isolated by bronchoscopic brushing indefinitely expanded in feeder-free condition. Expanded give rise...
Accurately identifying patients who respond to immunotherapy remains clinically challenging. A noninvasive method that can longitudinally capture information about immune cell function and assist in the early assessment of tumor responses is highly desirable for precision immunotherapy. Here, we show PET imaging using a granzyme B–targeted radiotracer named 68Ga-grazytracer, could noninvasively effectively predict checkpoint inhibitors adoptive T transfer therapy multiple models....
Abstract Fracture healing, in which osteoclasts and osteoblasts play important roles, has drawn much clinical attention. Osteoclast deficiency or decreased osteoblast activity will impair fracture healing. TRPV1 is a member of the Ca 2+ permeable cation channel subfamily, pharmacological inhibition prevents ovariectomy-induced bone loss, makes potential target for osteoporosis. However, whether long term deletion affect healing process unclear. In this study, we found that wild-type mice...
// Bo Jiang 1 , Ting Zhang 2 Fen Liu Zhangzhang Sun 3 Hanping Shi Dong Hua and Chen Yang 4 Department of Medical Oncology, Beijing Institute Translational Medicine, Chinese Academy Sciences/Cancer Center, Aviation General Hospital, Beijing, China Cancer, Affiliated Hospital Jiangnan University, Wuxi, Jiangsu, Nuclear-Medicine, Suzhou to Nanjing Suzhou, Correspondence to: Jiang, email: Yang, Keywords : B7-H3, colorectal cancer, epithelial-mesenchymal transition, co-stimulatory molecule,...
Chemoimmunotherapy has emerged as a promising strategy for improving the efficacy of cancer treatment. Herein, we present PD-1 receptor-presenting membrane-coated paclitaxel dimers nanoparticles (PD-1@PTX
To determine whether aggressive surgical management is more effective than local canal resection (LCR) for early-stage temporal bone malignancies.Retrospective study.Forty-three cases of external auditory (EAC) carcinoma who received between 1993 and 2011 were reviewed. Preoperative computed tomography, enhanced magnetic resonance imaging, pure-tone audiometry, biopsy performed. Patients underwent either LCR or lateral (LTBR). Postoperative pathologic examinations conducted on all specimens,...
American ginseng (<italic>Panax quinquefolium</italic>L.) was reported to have extensive biological activities and pharmaceutical properties.
Significance Although RT serves as a frontline therapy for more than 50% of patients with malignancies, its efficacy is limited to localized tumors. Efforts in harnessing the abscopal effect could systemically eliminate metastatic lesions disseminated beyond radiation field; however, success has been thus far, owing an inadequate understanding underlying mechanisms and absence reliable biomarkers early prediction. Here we demonstrate that noninvasive PET imaging ICAM-1 expression confers...
Abstract Background Immune checkpoint blockades (ICBs) therapy showed limited efficacy in ovarian cancer management. Increasing evidence indicated that conventional and targeted therapies could affect tumor-associated immune responses increase the effectiveness of immunotherapy. However, effects Niraparib, one poly (ADP) ribose polymerase (PARP) inhibitors, on response remains unclear. Delineating crosstalk between cytotoxic anticancer agents cancer-associated immunity may lead to more...
Abstract Introduction Endoscopic submucosal dissection (ESD) is a preferred treatment option for superficial esophageal squamous cell carcinoma (SESCC). However, only few studies compared long-term survival outcomes of ESD with surgery, especially T1b SESCC. This study the overall (OS), disease-free (DSS), recurrence-free (RFS), and complication rates both, to evaluate value in patients Methods We reviewed who underwent ( n = 47) or surgery 73) SESCC at Affiliated Hospital Nanjing University...
The overexpression of integrin α<sub>v</sub>β<sub>6</sub> in pancreatic cancer makes it a promising target for noninvasive PET imaging. However, currently, most α<sub>v</sub>β<sub>6</sub>–targeting radiotracers are based on linear peptides, which quickly degraded the serum by proteinases. Herein, we aimed to develop and assess <sup>68</sup>Ga-labeled cyclic peptide (<sup>68</sup>Ga-cycratide) imaging cancer. <b>Methods:</b><sup>68</sup>Ga-cycratide was prepared, its profile compared with...
Background: Radiotherapy (RT) may trigger systemic antitumor immunity, manifesting as regression of non-irradiated lesions (abscopal effect).Intracellular adhesion molecule-1 (ICAM-1) is a key molecule involved in the abscopal effect RT.However, specific function ICAM-1 CD8 + T cells during immune responses remains unclear.Herein, we investigated whether noninvasive imaging can be used to annotate T-cell function, thereby better selecting combinational therapy enhance immunity induced by...
Angiotensin II (Ang II) has been shown to function as a key role in neovascularization of hepatocellular carcinoma (HCC), but little is known its underlying mechanisms. The aim this study was explore the Janus kinase/signal transducer and activator transcription (JAK/STAT) signaling pathway Ang II-induced HCC angiogenic factors production. Herein, we found that upregulated production such vascular endothelial growth factor (VEGF), angiopoietin-2 (Ang-2) Tie-2 MHCC97H cells time-...
T helper (Th) 17 cells were reported to have the property of proinflammation and profibrosis. We first investigate levels Th17 in primary biliary cirrhosis (PBC) patients, then explore their distribution fibrotic role disease.We compared circulating hepatic interleukin (IL)-17-positive between patients healthy controls (HCs) at different disease stages by flow cytometry immunohistochemistry, respectively. The chemokine (c-c motif) ligand (CCL) 20 measured. For exploration reason why...
Article29 November 2019Open Access Source DataTransparent process Genetically engineered distal airway stem cell transplantation protects mice from pulmonary infection Yue-qing Zhou Department of Respiratory and Critical Care Medicine, Clinical Translation Research Center, Shanghai Pulmonary Hospital, Tongji University School Shanghai, China Search for more papers by this author Yun Shi East Tangdu Fourth Military Medical PLA, Xi'an, Ling Yang Yu-fen Sun Yu-fei Han Zi-xian Zhao Yu-jia Wang...