A5005192779- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Single-cell and spatial transcriptomics
- Pluripotent Stem Cells Research
Nanchang University
2014-2025
Chronic stress is generally known to exacerbate the development of numerous neuropsychiatric diseases such as fear and anxiety disorders, which at least partially due disinhibition amygdala subsequent prolonged exposure. GABA receptor A (GABAAR) mediates primary component inhibition in brain its activation produces two forms inhibition: phasic tonic inhibition. While both them are critically engaged limiting activity amygdala, their roles chronic exposure largely unknown. We investigated...
Dysregulated GABAergic inhibition in the amygdala has long been implicated stress-related neuropsychiatric disorders. However, molecular and circuit mechanisms underlying dysregulation remain elusive. Here, by using a mouse model of chronic social defeat stress (CSDS), we observed that varied drastically across individual projection neurons (PNs) basolateral (BLA), one kernel subregions critical for coping. While persistently reducing extrasynaptic GABAA receptor (GABAAR)-mediated tonic...
Chronic stress exposure is a primary contributor to the development of anxiety disorders, closely associated with hippocampal dysfunction. However, underlying molecular mechanism remains poorly understood. Here, using mouse model chronic restraint (CRS), we observed notable increase in activity, rather than its overall expression level, Rap1, small guanosine triphosphatase belonging Ras superfamily. Pharmacological inhibition Rap1 activity ventral hippocampus (vHPC) effectively mitigated...
Abstract Background Chronic stress exposure increases the risk of mental health problems such as anxiety and depression. The medial prefrontal cortex (mPFC) is a hub for controlling responses through communicating with multiple limbic structures, including basolateral amygdala (BLA) nucleus accumbens (NAc). However, considering complex topographical organization mPFC neurons in different subregions (dmPFC vs. vmPFC) across layers (Layer II/III Layer V), exact effects chronic on these...
The role of δ subunit-containing GABAA receptor (GABAA(δ)R) in fear generalization is uncertain. Here, by using mice with or without genetic deletion GABAA(δ)R and protocols which the conditioned tone stimuli were cross presented different nonconditioned stimuli, we observed that when two largely similar, both genotypes froze similarly to either them. However, they differed markedly, knockout much more than their wild-type littermates but not stimuli. Thus, may prevent inappropriate incoming...
Fear is an adaptive response across species in the face of threatening cues. It can be either innate or learned through postnatal experience. We have previously shown that genetic deletion both Rap1a and Rap1b, two isoforms small GTPase Rap1 forebrain, causes impairment auditory fear conditioning. However, specific roles these are not yet known.In present study, employing mice with forebrain-restricted we found they dispensable for normal acquisition learning. Rap1b but knockout (KO)...
Chronic or prolonged exposure to stress ranks among the most important socio-environmental factors contributing development of neuropsychiatric diseases, a process generally associated with loss inhibitory tone in amygdala. Recent studies have identified distinct neuronal circuits within basolateral amygdala (BLA) engaged different emotional processes. However, potential circuit involved stress-induced dysregulation tones BLA remains elusive. Here, transgenic mouse model expressing yellow...
Extinguishing the previously acquired fear is critical for adaptation of an organism to ever-changing environment, a process requiring engagement GABA
The δ subunit-containing GABAA receptor [GABAA(δ)R], which is exclusively situated in the extrasynaptic space, has considerable influence on emotion and behavior. Although expression of this experiences dramatic fluctuation during postnatal development, it remains unknown whether regulates a development-dependent manner. Here, by using mice with genetic deletion GABAA(δ)R (knockout) their wild-type littermates, we examined role regulating anxiety-like behavior, as measured open field test...
Abstract One of the most sought‐after topics in neuroscience is to understand how environment regulates activity and function neural circuitry subsequently influences relevant behaviors. In response alterations environment, circuits undergo adaptive changes ranging from gene expression altered cellular function. Performing sequencing transcriptome involved these behavior‐related will provide clues accurately dissect detailed mechanisms related behavior. Here, we describe methods for marking...