A5023467431- Cutaneous lymphoproliferative disorders research
- Fungal Infections and Studies
- CAR-T cell therapy research
- Nail Diseases and Treatments
- Ocular Surface and Contact Lens
- Antimicrobial Peptides and Activities
- Flavonoids in Medical Research
- Bacterial Identification and Susceptibility Testing
- Global Health Workforce Issues
- Parasites and Host Interactions
- Renal and related cancers
- T-cell and Retrovirus Studies
- Marine Ecology and Invasive Species
- Urologic and reproductive health conditions
- Cancer Immunotherapy and Biomarkers
- Ocular Infections and Treatments
- Oral Health Pathology and Treatment
- Bacterial Genetics and Biotechnology
- Vascular Tumors and Angiosarcomas
- Marine Invertebrate Physiology and Ecology
- Planarian Biology and Electrostimulation
- Biochemical and Structural Characterization
- Dermatological diseases and infestations
- Cancer and Skin Lesions
- Cutaneous Melanoma Detection and Management
University of California, Berkeley
2019-2025
Johns Hopkins Medicine
2025
Johns Hopkins University
2025
Hospital of the University of Pennsylvania
2016-2022
University of Hong Kong
2021
Sutter Health
2020
University of South Florida
2019
University of Maryland Medical Center
2017
University of Maryland, Baltimore
2017
Significance Comprehensive assessment of matrisome genes identified collagen IV as one the many extracellular matrix (ECM) proteins regulating stem cell pool in planarian tissue homeostasis and regeneration. While has been shown to be involved biology, our finding links it pluripotent cells vivo, including self-renewal differentiation into tissue-specific progenitors. We show a link between ECM niches parenchyma/gut region EGF/neuregulin-secreting neurons, thus providing mechanistic insight...
Despite surgical removal being considered the first-line treatment, managing high-risk squamous cell carcinoma (SCC) cases remains challenging and lacks uniformity as associated complications of less common secondary bacterial infections are underreported. The skin, well its appendages, constitute first line defense against infectious pathogens. In patients with locally aggressive skin cancers, susceptibility to microorganisms is elevated due lesions immunosuppression resulting from...
<title>Abstract</title> To safely dissipate excess excitation energy, photosynthetic organisms have evolved multiple photoprotection mechanisms. These mechanisms involve various molecular players functioning on overlapping timescales from seconds to days, making it challenging isolate and quantify their individual kinetics. In this study, we perform whole-leaf chlorophyll fluorescence lifetime xanthophyll concentration measurements wild-type newly characterized non-photochemical quenching...
The healthy cornea is remarkably resistant to infection, quickly clearing deliberately inoculated bacteria such as Pseudomonas aeruginosa and Staphylococcus aureus. Contrasting with the adjacent conjunctiva other body surfaces, it also lacks a resident viable bacterial microbiome. Corneal resistance microbes depends on intrinsic defenses involving tear fluid corneal epithelium. Dry eye, an ocular surface disease associated discomfort inflammation, can alter composition volume, impact...
Abstract The scavenging capacity of glycoprotein DMBT1 helps defend mucosal epithelia against microbes. binding to multiple bacterial species involves its conserved Scavenger Receptor Cysteine-Rich (SRCR) domains, localized a 16-mer consensus sequence peptide, SRCRP2. Previously, we showed that bound Pseudomonas aeruginosa pili, and inhibited twitching motility, pilus-mediated movement important for virulence. Here, determined molecular characteristics required motility inhibition....
The cornea of the eye differs from other mucosal surfaces in that it lacks a viable bacterial microbiome and by its unusually high density sensory nerve endings. Here, we explored role corneal nerves preventing adhesion. Pharmacological genetic methods were used to inhibit function or their associated transient receptor potential cation channels TRPA1 TRPV1. Impacts on adhesion, resident immune cells, epithelial integrity examined using fluorescent labeling quantitative confocal imaging....
Combination therapy with ipilimumab and nivolumab is an adjuvant treatment approach for metastatic melanoma that boasts increased 3-year survival when compared a single immunotherapy agent. therapy, however, associated toxicities, especially cutaneous side-effects. Here we present patient sudden eruption of painful nodules on the face arms 10 days after administration fourth dose combination ipilimumab/nivolumab. Biopsies demonstrated lymphoid hyperplasia, not clinically or pathologically...
Williford, Sarah; Heavner, Mojdeh; Lambing, Tyler; Wian, Brandi; Ma, Sophia; Gonzales, Jeffrey Author Information
Mature T-cell leukemias (MTCLs) are clonal proliferations of posttyhmic T cells that often exhibit systemic involvement including a variety cutaneous manifestations.1 Because the morphologic and phenotypic overlap, diagnosis MTCLs requires comprehensive assessment clinical presentation, immunophenotypic profiles, serologic, cytogenetic, molecular studies.2