A5100337133- Cardiac electrophysiology and arrhythmias
- Nitric Oxide and Endothelin Effects
- Ion channel regulation and function
- Cardiomyopathy and Myosin Studies
- Obstructive Sleep Apnea Research
- Eicosanoids and Hypertension Pharmacology
- Cardiac Fibrosis and Remodeling
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hormonal Regulation and Hypertension
- Signaling Pathways in Disease
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Immune Cell Function and Interaction
- Respiratory Support and Mechanisms
- Nutrition and Health in Aging
- Adenosine and Purinergic Signaling
- Diabetes Treatment and Management
- Body Composition Measurement Techniques
- Viral Infections and Immunology Research
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Heart Failure Treatment and Management
- Immune cells in cancer
- Angiogenesis and VEGF in Cancer
University of Utah
2021-2025
Children's Hospital of Chongqing Medical University
2019-2025
Chongqing Medical University
2019-2025
Tianjin Medical University
2020-2025
Shanghai Children's Medical Center
2025
Shanghai Jiao Tong University
2025
Tianjin First Center Hospital
2020-2025
Integrated Chinese Medicine (China)
2025
Beijing Friendship Hospital
2025
Capital Medical University
2011-2025
The selective cardiac myosin activator omecamtiv mecarbil has been shown to improve function in patients with heart failure a reduced ejection fraction. Its effect on cardiovascular outcomes is unknown.We randomly assigned 8256 (inpatients and outpatients) symptomatic chronic an fraction of 35% or less receive (using pharmacokinetic-guided doses 25 mg, 37.5 50 mg twice daily) placebo, addition standard heart-failure therapy. primary outcome was composite first event (hospitalization urgent...
ABSTRACT Background The effects of the sodium-glucose co-transporter 2 inhibitor empagliflozin on renal and cardiovascular disease have not been tested in a dedicated population people with chronic kidney (CKD). Methods EMPA-KIDNEY trial is an international randomized, double-blind, placebo-controlled assessing whether 10 mg daily decreases risk progression or death CKD. People without diabetes mellitus (DM) were eligible provided they had estimated glomerular filtration rate (eGFR) ≥20 but...
The involvement of lipid metabolism in tumourigenesis and the progression clear cell renal carcinoma (ccRCC) have been reported. However, role phospholipid profile alterations ccRCC has not yet systematically explored. In present study, we compared compositions between paired normal tissues. tissues were evaluated using liquid chromatography tandem mass spectrometry (LC/MS/MS). To evaluate mRNA protein levels lysophosphatidylcholine acyltransferase (LPCAT), which converts (LPC) to...
Isoproterenol-induced cardiac hypertrophy in mice has been used a number of studies to model human disease. In this study, we compared the transcriptional response heart other animal models failure, as well hearts suffering failure.We performed microarray analyses on RNA from with isoproterenol-induced and exercise-induced physiological identified 865 2,534 genes that were significantly altered pathological models, respectively. We our results 18 different data sets (318 individual arrays)...
Insulin and adrenergic stimulation are two divergent regulatory systems that may interact under certain pathophysiological circumstances. Here, we characterized a complex consisting of insulin receptor (IR) β2-adrenergic (β2AR) in the heart. The IR/β2AR undergoes dynamic dissociation diverse conditions such as Langendorff perfusions hearts with or after euglycemic-hyperinsulinemic clamps vivo. Activation IR induces protein kinase A (PKA) G-protein 2 (GRK2) phosphorylation β2AR, which...
Ischemic cardiomyopathy and resultant heart failure (HF) is a significant cause of morbidity mortality worldwide. Downregulation cardiac bridging integrator 1 (cBIN1), membrane scaffolding protein responsible for organizing t-tubules the calcium handing apparatus, occurs in progressive HF. Therefore, gene therapy upregulating cBIN1 production may rescue failing muscle clinical Adult mongrel dogs underwent ligation left anterior descending artery developed dilated chronic When ventricular...
Abstract Multiple heritable traits are associated with essential (genetic) hypertension in humans. Because chromogranin A is increased both human and rodent genetic hypertension, we examined the influence of heredity blood pressure on In estimates derived from among- within-pair variance monozygotic versus dizygotic twins, plasma displayed significant (F 15,18 =2.93, P =.016) (ς 2 g ), its broad-sense heritability was high ( h B =0.983). Plasma (99.9±6.7 62.8±4.7 ng/mL, <.001) but...
The present study was designed to investigate whether microRNAs (miRNAs) are involved in atrioventricular block (AVB) the setting of myocardial ischemia (MI). A cardiac-specific miR-1 transgenic (Tg) mouse model successfully established for first time this using microinjection. level measured by real-time qRT-PCR. Whole-cell patch clamp employed record L-type calcium current (I Ca,L) and inward rectifier K(+) K1). Expression connexin 43 (Cx43) protein determined western blot analysis....
Impaired Ca2 + cycling and myocyte contractility are a hallmark of heart failure triggered by pathological stress such as hemodynamic overload. The A-Kinase anchoring protein AKAP150 has been shown to coordinate key aspects adrenergic regulation Ca2+ excitation–contraction in cardiomyocytes. However, the role signalling complexes pathogenesis not investigated. Here we examined how impact cycling, contractility, susceptibility following stress. We detected significant reduction expression...
Rationale: In the endothelium, insulin stimulates endothelial NO synthase (eNOS) to generate antiatherosclerotic signaling radical NO. Insulin-resistant type 2 diabetes mellitus is associated with reduced availability and accelerated atherosclerosis. The effect of enhancing sensitivity on unclear. Objective: To answer this question, we generated a mouse cell (EC)–specific overexpression human receptor (hIRECO) using Tie2 promoter–enhancer. Methods Results: hIRECO demonstrated significant...
Heart failure is an important, and growing, cause of morbidity mortality. Half patients with heart have preserved ejection fraction, for whom therapeutic options are limited. Here we report that cardiac bridging integrator 1 gene therapy to maintain subcellular membrane compartments within cardiomyocytes can stabilize intracellular distribution calcium-handling machinery, preserving diastolic function in hearts stressed by chronic beta agonist stimulation pressure overload. This study...
Background Targeting immune checkpoints for HIV treatment potentially provides a double benefit resulting from the ability to restore viral-specific CD8 + T-cell functions and enhance production reservoir cells. Despite promising pre-clinical data, PD-1 blockade alone in HIV-1-infected patients with advanced cancer has shown limited benefits controlling HIV, suggesting need additional targets beyond PD-1. CD39 are highly co-expressed on T cells HIV-1 infection. However, characteristics of...
The adaptive immune system plays a critical role in hyperhomocysteinemia (HHcy)-accelerated atherosclerosis. Recent studies suggest that HHcy aggravates atherosclerosis with elevated oxidative stress and reduced S-nitrosylation level of redox-sensitive protein residues the vasculature. However, whether how contributes to T-cell-driven remain unclear. In present study, we report T cells by inducing S-nitrosoglutathione reductase (GSNOR), key denitrosylase catalyzes (GSNO), which is main...
Abstract The mechanisms via which inflammatory macrophages mediate intestinal inflammation are not completely understood. Herein, using merged analysis of RNA sequencing and mass spectrometry-based quantitative proteomics, we detected differences between proteomic transcriptomic data in activated macrophages. Dipeptidase-2 (DPEP2), a member the DPEP family, was highly expressed then downregulated sharply at protein level but mRNA response to stimulation. Suppression DPEP2 only enhanced...
To evaluate the incidence of ocular ischemic syndrome (OIS) in patients with asymptomatic Severe Internal Carotid Artery Stenosis or occluded (ipICA-SO). 260 ipICA stenosis ≥ 70%, 120 ipsilateral OIS, and 140 normal condition. The logistic regression analysis was conducted to establish risk prediction models OIS/Neovascular-OIS/Chronic-OIS for ipICA-SO. area under receiver operating characteristic curve (AUC) used test application value models. In ipICA-SO patients, OIS showed significantly...
This study aimed to investigate the safety and efficacy of costotransverse foramen block for postoperative analgesia in video-assisted thoracoscopic surgery (VATS). Seventy-five patients undergoing elective VATS under general anaesthesia were recruited this double-blind, non- inferiority trial randomized preoperatively receive a thoracic paravertebral (TPVB group), (CTFB or an erector spinae plane (ESPB group) with 0.5% ropivacaine 20 mL at T5 level. The primary outcome was numerical rating...