A5036992310- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Chronic Disease Management Strategies
- Diabetes Treatment and Management
- Chronic Kidney Disease and Diabetes
- Cardiac Valve Diseases and Treatments
- Nutrition and Health in Aging
- Cardiac pacing and defibrillation studies
- Cardiac Imaging and Diagnostics
- Blood Pressure and Hypertension Studies
- Pericarditis and Cardiac Tamponade
- Cardiac Structural Anomalies and Repair
- Eosinophilic Disorders and Syndromes
- Acute Myocardial Infarction Research
- Potassium and Related Disorders
- Cardiovascular and exercise physiology
- Renal Diseases and Glomerulopathies
- Heart Rate Variability and Autonomic Control
- Exercise and Physiological Responses
- Adrenal and Paraganglionic Tumors
- Inflammasome and immune disorders
- Physical Activity and Health
- Gamma-ray bursts and supernovae
Universitätsklinikum Würzburg
2019-2025
Deutsche Lepra- und Tuberkulosehilfe
2025
University of Würzburg
2020-2024
University of Oxford
2023
Comprehensive Cancer Center Mainfranken
2019-2022
Charles University
2011
WinnMed
2011
ABSTRACT Background The effects of the sodium-glucose co-transporter 2 inhibitor empagliflozin on renal and cardiovascular disease have not been tested in a dedicated population people with chronic kidney (CKD). Methods EMPA-KIDNEY trial is an international randomized, double-blind, placebo-controlled assessing whether 10 mg daily decreases risk progression or death CKD. People without diabetes mellitus (DM) were eligible provided they had estimated glomerular filtration rate (eGFR) ≥20 but...
Sodium-glucose transport protein 2 inhibitors (SGLT2i) slow the progression of renal dysfunction and improve prognosis patients with heart failure. Amyloidosis constitutes an important subgroup for which evidence is lacking. Amyloidotic fibrils originating from misfolded transthyretin light chains are causal agents in ATTR AL amyloidosis. In these most frequent subtypes, cardiac involvement common organ manifestation. Because function frequently deteriorate over time, even under best...
Background Recently, myocardial work analysis as an echocardiographic tool to non-invasively determine LV has been introduced and validated against invasive measurements. Based on systolic blood pressure speckle-tracking derived longitudinal strain (GLS) during systole isovolumic relaxation, it is considered less load-dependent than ejection fraction (LVEF) or GLS integrate information active diastolic work. Objectives We aimed establish reference values for global constructive (GCW) wasted...
Significance Statement SGLT2 inhibitors reduce risk of kidney progression, AKI, and cardiovascular disease, but the mechanisms benefit are incompletely understood. Bioimpedance spectroscopy can estimate body water fat mass. One quarter EMPA-KIDNEY bioimpedance substudy CKD population had clinically significant levels bioimpedance-derived “Fluid Overload” at recruitment. Empagliflozin induced a prompt sustained reduction in Overload,” irrespective sex, diabetes, baseline N-terminal pro B-type...
Few studies have reported neuropsychiatric symptoms (NPS) in primary progressive aphasia (PPA), a neurodegenerative disorder that primarily affects the left hemisphere. Depression is associated with left-sided stroke, but it remains unclear whether depression and other NPS are also PPA. The authors compared frequency of 55 cases PPA 110 cognitively normal persons matched for age, sex, education. Depression, apathy, agitation, anxiety, appetite change, irritability Hallucinations, delusions,...
Prevention of heart failure relies on the early identification and control risk factors. We aimed to identify frequency characteristics individuals at in general population.We report cross-sectional data from prospective Characteristics Course Heart Failure Stages A-B Determinants Progression (STAAB) cohort study investigating a representative sample residents Würzburg, Germany. Sampling was stratified 1:1 for sex 10:27:27:27:10 age groups 30-39/40-49/50-59/60-69/70-79 years. precursor...
Abstract Myocardial work is a new echocardiography-based diagnostic tool, which allows to quantify left ventricular performance based on pressure–strain loops, and has been validated against invasively derived pressure–volume measurements. described by its components (global constructive [GCW], global wasted [GWW]) indices index [GWI], efficiency [GWE]). Applying this innovative concept, we characterized the prevalence severity of subclinical compromise in general population estimated...
Abstract Aims The 6-min walk test is an inexpensive, safe, and easy tool to assess functional capacity in patients with cardiopulmonary diseases including heart failure (HF). There a lack of reference values, which are prerequisite for the interpretation results patients. Furthermore, determinants independent respective disease need be considered when interpreting distance (6MWD). Methods prospective Characteristics Course Heart Failure Stages A-B Determinants Progression (STAAB) cohort...
Abstract Aims Heart failure (HF) impairs skeletal muscle mass and function, which contributes to reduced physical performance. We investigated the prognostic impact of gait speed (GS), handgrip strength (HG) appendicular index (ASMI) on cardiovascular outcomes in a prospective HF cohort. Methods This single‐centre cohort study included adults with stable chronic previous diagnosis overtly left ventricular ejection fraction (LVEF) <40% LVEF < 50% at enrolment. GS was measured by 4 m...
Introduction: Left ventricular (LV) dilatation and LV hypertrophy are acknowledged precursors of myocardial dysfunction ultimately heart failure, but the implications abnormal geometry on function not well-understood. Non-invasive work (MyW) assessment based echocardiography-derived pressure-strain loops offers opportunity to study detailed in larger cohorts. We aimed assess relationship with MyW indices general population free from failure. Methods Results: report cross-sectional baseline...
Abstract Background There are emerging interventional treatment options targeting tricuspid regurgitation (TR) in patients with heart failure. Nevertheless, community-based data regarding acute failure (AHF) scarce. Purpose To determine prevalence, in-hospital course and prognostic value of TR an all-comer collective hospitalized for AHF. Methods In a university tertiary care center, AHF between 2015 2020 were included prospective registry (n= 1000). We abstracted clinical routine...
Abstract Background Valvular heart disease (VHD) is a major burden to public health. The complexity and the long asymptomatic phase of VHD pose significant challenges its recognition monitoring. Assuming gradual progression, ACC/AHA define consecutive stages from "at risk" through "progressive stage" "severe symptomatic VHD". Purpose To determine frequency course in general population estimate their respective prognostic value regarding all-cause mortality. Methods STAAB study recruited...
Abstract Left ventricular (LV) rotational function parameters provide in-depth information about LV mechanical as well prognostic information. Using three-dimensional (3D) echocardiography, we identified determinants of “twist” and “torsion”, established reference values using a large population-based cohort. 3D echocardiography images were recorded in n = 2803 subjects within the prospective STAAB cohort study investigating representative age- sex-stratified sample residents city Würzburg,...
Abstract Background and aims Endogenous Cushing's syndrome (CS) is characterized by an unfavorable cardiovascular (CV) metabolic risk profile, but the potential adverse effects of hypercortisolism on myocardial function are not well known. Myocardial Work analysis a new echocardiographic method that utilizes left ventricular pressure-strain loops to quantify cardiac performance independent afterload. Methods results In cross-sectional analysis, we compared four groups: patients with overt...
Myalgic Encephalomyelitis/ Chronic Fatigue syndrome (ME/CFS) is a complex, debilitating, long-term illness without diagnostic biomarker. ME/CFS patients share overlapping symptoms with long COVID patients, an observation which has strengthened the infectious origin hypothesis of ME/CFS. However, exact sequence events leading to disease development largely unknown for both clinical conditions. Here we show antibody response herpesvirus dUTPases, particularly that Epstein-Barr virus (EBV) and...
Abstract Purpose Systemic amyloidosis represents a yet poorly characterized complex and multifaceted rare multisystem disease with high mortality. Clinical presentation, clinical course, treatment vary within across subtypes. Established biomarkers are predominantly non-specific. Diagnosis management of these patients require specifically tailored interdisciplinary structures. Well-characterized patient cohorts needed to optimize diagnostic tools options. Method The prospective cohort study...
Abstract Aims Data on the clinical profiles of patients with transthyretin amyloidosis cardiomyopathy (ATTR‐CM) in post‐approval era tafamidis 61 mg are lacking. Study aims were characterization contemporary ATTR‐CM patients, analysis potential eligibility for ‘Transthyretin Amyloidosis Cardiomyopathy Clinical Trial’ (ATTR‐ACT) and identification factors associated decision treatment. Methods results This retrospective study analysed seen at eight University Hospitals first year after...
Abstract Aims Systolic ejection time (SET) is discussed as a treatment target in patients with heart failure (HF) and reduced left ventricular (LV) fraction (EF). We derived reference values for SET correcting its dependence on rate (SETc), explored prognostic utility admitted decompensated HF. Methods results SETc was 4836 participants of the population-based STAAB study (mean age 55 ± 12 years, 52% women). There, mean 328 18 ms, increased (+4.7 ms per decade), shorter men than women (−14.9...
The incidental finding of a pericardial effusion (PE) poses challenge in clinical care. PE is associated with malignant conditions or severe cardiac disease but may also be observed healthy individuals. This study explored the prevalence, determinants, course, and prognostic relevance population-based cohort.
Knowledge about a patient's physical fitness can aid in medical decision-making, but objective assessment be challenging and time-consuming. We aimed to investigate the concordance of self-reported health status functioning with 6 minute walking distance (6MWD) as measure performance. The prospective characteristics course heart failure stages A/B determinants progression (STAAB) cohort study iteratively follows representative sample residents city Würzburg, Germany, aged 30-79 years,...
Adipose tissue contributes to adverse outcomes in chronic kidney disease (CKD), but there is uncertainty regarding the prognostic relevance of different adiposity measures. We analyzed associations neck circumference (NC), waist (WC), and body mass index (BMI) with clinical patients mild severe CKD.The German Chronic Kidney Disease study a prospective cohort study, which enrolled Caucasian adults CKD, defined as estimated glomerular filtration rate : 30-60 mL/min/1.73 m2, or >60 m2 presence...