A5000222943- Amyloidosis: Diagnosis, Treatment, Outcomes
- Parathyroid Disorders and Treatments
- Dermatological and Skeletal Disorders
- Protein Kinase Regulation and GTPase Signaling
- Peptidase Inhibition and Analysis
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pancreatitis Pathology and Treatment
- Lung Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
- IgG4-Related and Inflammatory Diseases
- Diabetes Treatment and Management
- Cancer Treatment and Pharmacology
- Adrenal and Paraganglionic Tumors
- Bone health and treatments
- Eosinophilic Disorders and Syndromes
- Chemotherapy-induced cardiotoxicity and mitigation
- Hormonal Regulation and Hypertension
- Cardiac tumors and thrombi
- Trace Elements in Health
- Radiation Therapy and Dosimetry
- Multiple Myeloma Research and Treatments
- Advanced Radiotherapy Techniques
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Medical Imaging and Pathology Studies
Universitätsklinikum Würzburg
2019-2025
Lund University
2023-2025
Universitätsklinikum Gießen und Marburg
2024-2025
Deutsches Herzzentrum der Charité
2020
Sodium-glucose transport protein 2 inhibitors (SGLT2i) slow the progression of renal dysfunction and improve prognosis patients with heart failure. Amyloidosis constitutes an important subgroup for which evidence is lacking. Amyloidotic fibrils originating from misfolded transthyretin light chains are causal agents in ATTR AL amyloidosis. In these most frequent subtypes, cardiac involvement common organ manifestation. Because function frequently deteriorate over time, even under best...
Background: Congestion is associated with poor prognosis in cardiac amyloidosis (CA). The cardio-hepatic interaction and the prognostic impact of secondary liver affection by congestion CA are poorly understood require further characterisation. Methods: Participants cohort study AmyKoS at Interdisciplinary Amyloidosis Centre Northern Bavaria proven transthyretin (ATTR-CA) light chain (AL-CA) underwent serial work-up including laboratory tests, echocardiography, in-depth hepatic assessment...
Abstract Background Amyloidosis represents a rare yet heterogeneous multi-system disorder associated with grave prognosis and an enormous psycho-emotional strain on patients, relatives, caregivers. We here present the overall study design first results of A MY-NEED S , research program aiming to systematically assess needs patients suffering from amyloidosis, their relatives health care professionals (HCPs), develop amyloidosis-specific approach. Methods uses mixed-methods approach including...
Abstract Objective To investigate the feasibility of active heart sparing (AHS) planning in patients with locally advanced and centrally located NSCLC receiving standard definitive radiotherapy (RT), while maintaining or improving appropriate lung, esophagus, spinal cord constraints target volume (PTV) coverage intent. Methods materials A total 27 stage IIIA/B treated curative intent RT were selected for this analysis. All existing radiation plans revised further new equivalent calculated...
Abstract Purpose Systemic amyloidosis represents a yet poorly characterized complex and multifaceted rare multisystem disease with high mortality. Clinical presentation, clinical course, treatment vary within across subtypes. Established biomarkers are predominantly non-specific. Diagnosis management of these patients require specifically tailored interdisciplinary structures. Well-characterized patient cohorts needed to optimize diagnostic tools options. Method The prospective cohort study...
Introduction Neuropathy in transthyretin (ATTR) amyloidosis is frequently underdiagnosed, delaying effective treatment. Early detection of large- and small-nerve fiber damage via a comprehensive diagnostic algorithm impacts on clinical management.Methods A mixed cohort patients with ATTR (wild type-wt, hereditary-v TTR gene mutation carriers) the Interdisciplinary Amyloidosis Centre Northern Bavaria underwent examination, nerve conduction studies (NCS), quantitative sensory testing (QST),...
Multiple myeloma (MM) is the second most common hematologic malignancy and occurs similar to cardiovascular diseases (CVD), in sixth/seventh decade. The aim of this retrospective cohort study was evaluate prevalence prognostic value risk factors (CVRF) CVD 325 patients with MM undergoing autologous peripheral blood stem cell transplantation (PBSCT) at University Hospital Würzburg between 03/2004 12/2011. Mean age total 61 years. Among CVRF, arterial hypertension highest (59.7%), followed by...
Background Statistical analyses of clinical data are a cornerstone in understanding pathomechanisms disorders. In rare disorders, cross-sectional datasets sufficient size usually not available. Taking AA amyloidosis as an example life-threatening disorder resulting from uncontrolled chronic inflammation, we propose techniques time series analysis to predict organ response treatment. The advantage time-series is that it solely relies on temporal variation and therefore allows analyzing...
Background Amyloidosis is a rare multi-system disorder associated with frequently delayed diagnosis, enormous disease burden and psychosocial distress. Methods Systematic assessment of needs was performed by subtype-spanning questionnaire-based survey within the A MY-NEED S research care program. Results 118 patients proven amyloidosis (62.7% ATTR, 22.0% AL, 15.3% other forms) were included in August 2020 until February 2021 (mean age 71.2 ±11.3 years; 30% women). The median diagnostic delay...
<title>Abstract</title> Background To investigate the feasibility of active heart sparing (AHS) planning in patients with locally advanced and centrally located NSCLC receiving definitive radiotherapy (RT). Methods A total 27 treated definitve RT were selected. All existing radiation plans revised further new equivalent calculated using AHS for same cohort. Primary end-point was constraints substructures. The secondary end point to calculate difference terms dosimetric parameters...