A5100413881- Phytochemicals and Antioxidant Activities
- RNA modifications and cancer
- Neuroendocrine regulation and behavior
- Wastewater Treatment and Nitrogen Removal
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Plant Water Relations and Carbon Dynamics
- Gut microbiota and health
- Spine and Intervertebral Disc Pathology
- Soil Carbon and Nitrogen Dynamics
- Chemical Synthesis and Analysis
- Nanoparticle-Based Drug Delivery
- Evolutionary Psychology and Human Behavior
- Cancer-related gene regulation
- Enzyme Catalysis and Immobilization
- Glycosylation and Glycoproteins Research
- Infant Nutrition and Health
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- Adenosine and Purinergic Signaling
- Carbohydrate Chemistry and Synthesis
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
Huashan Hospital
2021-2025
Fudan University
2021-2025
Liaoning Normal University
2023-2025
Second Xiangya Hospital of Central South University
2021-2025
Central South University
2021-2025
Yamagata University
2024-2025
Southern Medical University
2025
Shandong University of Traditional Chinese Medicine
2025
Jiangsu University of Science and Technology
2024-2025
Nanfang Hospital
2025
Intermittent fasting (IF) has been reported to have beneficial effects on improving gut function via lowering inflammation and altering the microbiome diversity. In this study, we aimed investigate differential of three different common IF treatments, alternate day (ADF), time-restricted (TRF), intermittent energy restriction (IER), a dextran sodium sulfate (DSS)-induced colitis mouse model. The results indicated that TRF IER, but not ADF improved survival rates mice. ADF, reversed...
A quantum-dot (QD)-based micelle conjugated with an anti-epidermal growth factor receptor (EGFR) nanobody (Nb) and loaded anticancer drug, aminoflavone (AF), has been engineered for EGFR-overexpressing cancer theranostics. The near-infrared (NIR) fluorescence of the indium phosphate core/zinc sulfide shell QDs (InP/ZnS QDs) allowed in vivo nanoparticle biodistribution studies. anti-EGFR 7D12 conjugation improved cellular uptake cytotoxicity QD-based micelles MDA-MB-468 triple-negative breast...
Antenatal obesity increases the risk of postpartum depression. Previous research found that dietary fiber supplementation could alleviate mental behavioral disorders. The present study aims to uncover effects high-dietary intake on high-fat diet (HFD)-induced depressive-like behaviors and its underlying mechanism. Female C57BL6/J mice were fed with HFD establish an antenatal obese model. A (inulin, 0.037 g/kcal) significantly attenuated cognitive deficits in maternal after offspring weaning....
FCPS effectively alleviates DSS-induced colitis, possibly<italic>via</italic>its beneficial effects on reshaping the gut microbiome and enhancing formation of SCFAs.
Oxidative stress is a highly active metabolic process in the liver, that poses great threats to disseminated tumor cells during their colonization. Here, we aimed investigate how colorectal cancer (CRC) overcome lipid peroxidation sustain metastatic colonization liver.Orthotopic liver metastasis (CRLM) and CRC mouse models were constructed determine roles of AADAC The levels detected or tissues. overexpression LMs its clinical relevance analyzed. oncogenic role was evaluated cell...
We investigated the chemical structures and conformational isomers of cyclic heptapeptides stylissamide H euryjanicin A isolated from marine sources. Despite sharing same molecular structure, exhibit different in solution solid states. The main difference arises cis/trans configurations two Pro residues. prepared using Fmoc solid-phase peptide synthesis its structure state via NMR spectroscopy X-ray crystallography, respectively. results indicated that s-trans,cisPro conformer is more stable...
Sulfate templation has been used in the synthesis of a novel tris-urea-based triply interlocked capsule, whose structure verified by DOSY NMR, mass spectrometry and molecular modelling investigations.
Raman spectroscopy has been widely used for label-free biomolecular analysis of cells and tissues pathological diagnosis in vitro vivo. AI technology facilitates disease based on spectroscopy, including machine learning (PCA SVM), manifold (UMAP), deep (ResNet AlexNet). However, it is not clear how to optimize the appropriate classification model different types spectral data. Here, we selected five representative data sets, endometrial carcinoma, hepatoma extracellular vesicles, bacteria,...
ω-3 polyunsaturated fatty acids, naturally found in fish oil, are highly desirable for their associated health benefits. However, they prone to oxidation and degradation. We examined the feasibility of simultaneously adding a solid lipid (palmitic acid) an antioxidant (quercetin) into whey-protein-isolate-stabilized nanoparticle emulsion encapsulating oil. The goal was find rational new formulation containing both that can encapsulate oil give it best physicochemical stability. Our results...
This study examined the EFL writing performance of using AI-based feedback called Grammarly and students’ acceptance this new technology. Fifty-three students from two convenience sample classes in China participated quasi-experimental design study. They were randomly assigned to experimental control groups. The group (EG) applied edit revise their essays, while those (CG) received traditional instruction without intervention. A total five essays implemented during 16-week intervention...
Paternal care plays a critical role in the development of brain and behaviors offspring monogamous species. However, neurobiological mechanisms, especially neuronal circuity, underlying paternal is largely unknown. Using socially male mandarin voles (<i>Microtus mandarinus</i>) with high levels care, we found that paraventricular nucleus hypothalamus (PVN) to ventral tegmental area (VTA) or accumbens (NAc) oxytocin (OT) neurons are activated during care. Chemogenetic activation/inhibition...
Abstract Background Chemotherapy is an important strategy for the treatment of hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR+HER2−) breast cancer (BC), but this subtype has a low response rate to chemotherapy. Growing evidence indicates that N 6 -methyladenosine (m A) most common RNA modification in eukaryotic cells and methyltransferase-like 3 (METTL3) participates tumour progression several types. Therefore, exploring function METTL3 HR+HER2− BC initiation...
Ferulic acid (FA) is one of the most abundant bound phenolics in whole grains, partly contributing to its preventive effects on metabolic syndrome (MetS). The study aims investigate if FA mediates MetS through regulation hepatic metabolisms and insulin receptor related pathways palmitate-treated HepG2 cells (MetS model). We found that (50, 100, 200 μM) dramatically ameliorated lipid accumulation model. significantly decreased activities gluconeogenic enzymes, G6Pase PEPCK, downregulated...
This study aimed to investigate the causal risk factors for intervertebral disc disorders (IVDD) help establish prevention strategies IVDD-related diseases. We performed two-sample Mendelian randomization analyses effects of body mass index (BMI), education, and lifestyle behaviors (sedentary behavior, smoking, sleeping) on thoracic/thoracolumbar/lumbosacral IVDD (TTL-IVDD) cervical IVDD. The inverse-variance weighted (IVW) method was conducted as primary model pool effect sizes using odds...