A5100783340- Monoclonal and Polyclonal Antibodies Research
- HER2/EGFR in Cancer Research
- Advancements in Battery Materials
- Advanced Battery Materials and Technologies
- Advanced Biosensing Techniques and Applications
- Cancer Treatment and Pharmacology
- Food composition and properties
- Advanced battery technologies research
- Supercapacitor Materials and Fabrication
- Polysaccharides Composition and Applications
- High Temperature Alloys and Creep
- Immune Cell Function and Interaction
- Nanoparticle-Based Drug Delivery
- MXene and MAX Phase Materials
- Microbial Metabolites in Food Biotechnology
- Advanced Breast Cancer Therapies
- Immunotherapy and Immune Responses
- Intermetallics and Advanced Alloy Properties
- Layered Double Hydroxides Synthesis and Applications
- RNA Interference and Gene Delivery
- Advanced Battery Technologies Research
- RNA modifications and cancer
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Fungal Biology and Applications
Anhui Agricultural University
2023-2025
Fudan University Shanghai Cancer Center
2013-2025
University of Jinan
2024-2025
Shandong University
2019-2024
Shenzhen University Health Science Center
2022-2024
Shenzhen Second People's Hospital
2021-2024
Shanghai Medical College of Fudan University
2014-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Chinese Academy of Sciences
2022
Shenzhen Institutes of Advanced Technology
2022
Abstract Aqueous static zinc–iodine batteries attract tremendous attention because of their abundant reserves iodine, nonflammable electrolyte, and facile assembly. Currently, scientific challenges for include self‐discharge sluggish kinetics. Herein, a lithiation approach the iodine host to suppress shuttle effect catalyze conversion is reported. Through regulating d ‐ p ‐band center lowering I − /I 0 barrier, Li + intercalation into VS 2 reinforces interaction with 3 achieves catalytic...
Abstract A major challenge in vaccine delivery is to achieve robust lymph‐node (LN) accumulation, which can capitalize on concentrated immunocytes and cytokines LNs stimulate the onset persistence of adaptive immune responses. Previous attempts at developing systems have focused sizes, charges, or surface ligands but not their deformability. In fact, LN homing antigen‐presenting cells depends deformability pass through cellular gaps. Herein, albumin‐stabilized emulsions engineered. Owing...
The hydrogen evolution reaction and heterogeneous deposition may cause inferior reversibility stability of the Zn anode for neutral aqueous Zn-metal batteries. Notably, slow kinetics plays a pivotal role in mitigating Zn2+ concentration gradient facilitating an elevation overpotential evolution. Here, straightforward electrolyte tactic is implemented to create predeposition layer characterized by weak adsorption capability, coupled with electric double featuring relatively positive charge...
KN026 is a novel bispecific antibody that simultaneously binds to two distinct HER2 epitopes. This first-in-human phase I study evaluated the safety/tolerability, pharmacokinetics, preliminary efficacy, and potential predictive biomarker activity of administered as monotherapy patients with HER2-positive metastatic breast cancer (MBC).Female MBC who had progressed on prior anti therapies received intravenous at 5 mg/kg (once weekly), 10 20 every 2 weeks), or 30 3 weeks). Dose escalation was...
Abstract Exosomes are carriers of intercellular information that regulate the tumor microenvironment, and they have an essential role in drug resistance through various mechanisms such as transporting RNA molecules proteins. Nevertheless, their effects on gemcitabine triple-negative breast cancer (TNBC) unclear. In present study, we examined exosomes TNBC cell viability, colony formation, apoptosis, annexin A6 (ANXA6)/EGFR expression. We addressed roles underlying mechanism. Our results...
Abstract Chalcogenide cathodes with multi‐electron transfer characteristics are indispensable to aluminum‐ion batteries (AIBs). Nevertheless, their grievous capacity degradation and sluggish reaction kinetics remain fundamental challenges for the practical application. Herein, a Cu 2 S/Ni 3 S multiphase structure within metal‐organic frame (MOF) derived carbon decoration layer (CNS@MC) is constructed elevate intrinsic electronic properties of chalcogenide cathode realize high‐performance...
Epithelial–mesenchymal transition (EMT) is a critical event in metastasis of colorectal cancer (CRC). Rho/ROCKs signaling has pivotal role orchestrating actin cytoskeleton, leading to EMT and invasion. However, the underlying mechanisms for ROCKs activation are not fully understood. Here, we identified FOXM1D, novel isoform Forkhead box M1 (FOXM1) that by directly interacting with coiled-coil region ROCK2. FOXM1D overexpression significantly polymerizes assembly impairs E-cadherin...
Up to one-third of diffuse large B cell lymphoma (DLBCL) patients eventually develop resistance R-CHOP regimen, while the remaining therapeutic options are limited. Thus, understanding underlying mechanisms and developing approaches urgently needed. Methods: We generated two germinal center cell-like (GCB) activated (ABC) subtype R-CHO resistant DLBCL lines, which tumor-initiating capacity was evaluated by serial-transplantation stemness-associated features including CD34 CD133 expression,...
Pyrotinib is a newly-developed irreversible pan-ErbB receptor tyrosine kinase inhibitor. This study reported the first real-world data of pyrotinib-based therapy in metastatic human epidermal growth factor 2 (HER2)-positive breast cancer (BC), focusing on efficacy lapatinib-treated patients and brain metastasis.One hundred thirteen with HER2-positive BC treated Fudan University Shanghai Cancer Center under non-clinical trial settings from September 1, 2018 to March 2019 were included.Over...
Aqueous Zn batteries with a practical TiTe 2 anode deliver remarkable capacity and outstanding long-term stability.
Defect engineering using boron doping endows aluminum–graphene batteries with high capacity and outstanding long-term stability of more than 10 000 cycles.
Dual-defect strategy of Ti-intercalation and Se-vacancies modulates the electronic structural properties MoSe 2 , achieving high-performance aluminum batteries.