A5101482658- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Renal cell carcinoma treatment
- Cancer Research and Treatments
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Gestational Diabetes Research and Management
- Cancer, Hypoxia, and Metabolism
- GABA and Rice Research
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Natural Antidiabetic Agents Studies
- Hepatitis B Virus Studies
- RNA Interference and Gene Delivery
- Advanced Biosensing Techniques and Applications
- Eicosanoids and Hypertension Pharmacology
- Autophagy in Disease and Therapy
- Advanced biosensing and bioanalysis techniques
- Kruppel-like factors research
- Melanoma and MAPK Pathways
- Pregnancy-related medical research
Lanzhou University
2024-2025
First Hospital of Lanzhou University
2024-2025
Southern Medical University
2025
Shanghai University of Traditional Chinese Medicine
2025
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2025
Chinese People's Liberation Army
2023
Nanjing Agricultural University
2023
Guiyang Medical University
2022
Zunyi Medical University
2022
Nanjing Medical University
2009-2022
Over recent years, cell surface nucleolin as an anticancer target has attracted many researchers' attentions. To improve the antitumor efficacy, we developed a targeted protein nanoparticle (NTPN) delivery system in which human serum albumin (HSA) was used drug carrier and DNA aptamer named AS1411, had high affinity to nucleolin, bullet. The HSA nanoparticles (NPs-PTX) were fabricated by novel self-assembly method then modified with AS1411 (Apt-NPs-PTX). resulted Apt-NPs-PTX spherical....
Purpose This multicenter, open-label, phase Ib/II study aimed to assess the efficacy and safety of cadonilimab, a humanized, tetravalent, bispecific antibody plus lenvatinib in first-line treatment advanced hepatocellular carcinoma (aHCC). Methods Patients with histologically confirmed aHCC were included receive either 6 mg/kg cadonilimab every 2 weeks (cohort A) or 15 3 B). The primary endpoint was objective response rate (ORR) by RECIST v1.1, while secondary endpoints safety,...
Epithelial–mesenchymal transition (EMT) is a critical event in metastasis of colorectal cancer (CRC). Rho/ROCKs signaling has pivotal role orchestrating actin cytoskeleton, leading to EMT and invasion. However, the underlying mechanisms for ROCKs activation are not fully understood. Here, we identified FOXM1D, novel isoform Forkhead box M1 (FOXM1) that by directly interacting with coiled-coil region ROCK2. FOXM1D overexpression significantly polymerizes assembly impairs E-cadherin...
Abstract Extracellular vesicles (EVs) are important for cell-to-cell communication in animals. EVs also play roles plant–microbe interactions, but the underlying mechanisms remain elusive. Here, proteomic analyses of from soybean ( Glycine max ) root rot pathogen Phytophthora sojae identify tetraspanin family proteins PsTET1 and PsTET3, which recognized by Nicotiana benthamiana to trigger plant immune responses. Both required full virulence P. . The large extracellular loop (EC2) PsTET3 is...
<title>Abstract</title> Amphiregulin (AREG), as another EGF family member, is anchored to the cell surface a transmembrane protein. In response external stimulus, its extracellular domain can be release matrix in paracrine or autocrine manner. However, what it plays septic macrophages pyroptosis remain poorly understood. The role of AREG was investigated macrophages, mice well patients. Here, we found that highly expressed sepsis increased expression IL-6 protein and Caspase 1, IL-1β, Nlrp3...
This study aimed to evaluate the risk of tumor formation with infliximab or azathioprine monotherapy versus their combination, using FDA Adverse Event Reporting System (FAERS) database. Data were extracted from FAERS database for patients treated infliximab, azathioprine, and combination therapy Q1 2004 Q2 2024. Signal mining employed methods such as Reported Odds Ratio (ROR), Proportional (PRR), Multiple Gamma-Poisson Scaling Assessment (MGPSA) Bayesian Confidence Interval Progressive...
Amphiregulin (AREG), a member of the EGF family, exists as transmembrane protein anchored to cell surface. In response external stimuli, its extracellular domain is released into matrix through paracrine or autocrine signaling. However, role in septic macrophage pyroptosis remains poorly understood. This study aims investigate AREG macrophages, mice, and patients. We found that high expression was regulated by RPLP1 at translation level, which increased IL-6, CCL2, CCL3 protein, well Caspase...
Perianal abscesses are a common anorectal condition characterized by painful collections of pus near the anus and rectum. Surgical intervention is standard treatment, yet postoperative pain can significantly impact patients' quality life (QoL). Understanding variability in experiences their association with QoL crucial for improving outcomes. This study included 575 patients who underwent surgical perianal between 2021 2023. Pain intensity was assessed using Visual Analog Scale at multiple...
Objectives This study aimed to explore the expression of eukaryotic translation initiation factor 3 subunit C-like in serous ovarian cancer samples (both paraffin-embedded and fresh samples) evaluate its clinical value patients with cancer. Methods Twenty-five tissues their paired paratumor were subjected reverse transcription–quantitative polymerase chain reaction assay detect messenger RNA expression. In addition, 135 36 assessed for protein using immunohistochemistry. Results Both levels...
The inappropriate activation of complement may contribute to various immune diseases. alternative pathway (AP) predominates during regardless the initiating pathways. Hence, main AP regulator factor H (FH) holds great potential as an attractive therapeutic intervention. In addition, receptor immunoglobulin superfamily (CRIg) has been demonstrated inhibit and, more notably, still specifically binds C3b/iC3b. We thus developed novel CRIg-targeted inhibitors by connecting functional domains...
Endoplasmic reticulum stress (ERS), mutual crosstalk between autophagy and apoptosis-related signaling pathway, plays an important role in the process of acute liver injury (ALI). The present study was to investigate effects underlying mechanisms Asiatic acid from Potentilla chinensis (AAPC) on ALI. model ALI mice induced by administration with Lipopolysaccharide/D-Galactosamine (LPS/D-GalN). AAPC hepatic pathology hepatocyte apoptosis were observed hematoxylin-eosin (H&E) staining TUNEL...
Lipid metabolism has been associated with progression of various cancers. However, the underlying mechanisms impact lipid metabolism-associated genes (LMAGs) on tumor immune microenvironment have not well-elucidated. This study aimed to determine effects and development hepatocellular carcinoma (HCC). Expression profiles clinical data 371 231 patients HCC were obtained from TCGA Internal Cancer Genome Consortium (ICGC) databases, respectively. Using Cox regression LASSO analyses, a...
Obesity in women of reproductive age is not only associated with numerous adverse maternal and fetal effects prenatally but also exerts a negative influence on female fertility. The aim this study was to investigate the situation prepregnant obesity Shanghai explore impact gestational weight gain as well other pregnancy outcomes. A prospective hospital-based pregnant cohort established since January 2015. All who were registered expected deliver hospital included cohort. Nearly one fourth...
4592 Background: Advanced HCC is a deadly disease with few systemic therapeutic options. VEGF blockade potentiates the effect of PD-1 inhibition by opposing immunosuppressive effects VEGF-A (increased DC maturation, enhanced T-cell infiltration, reduced MDSCs and Tregs in tumors). A sBLA has been submitted for an anti-PD-L1 + anti-VEGF combination as 1L treatment advanced HCC. Penpulimab novel humanized anti-PD-1 IgG1 antibody complete removal Fc receptor mediated effect, featuring slow...
Objective: To explore the underlying molecular mechanism of Notch1/cadherin 5 (CDH5) pathway in modulating cell malignant behaviors gastric cancer (GC). Methods: We performed bioinformatic analyses to screen potential target genes Notch1 from cadherins GC. Western blot and RT-PCR were conducted detect CDH5 expression GC tissues cells. utilized chromatin immunoprecipitation (CHIP) assays assess interaction with gene. The effects Notch1/CDH5 axis on proliferation, invasion, migration...
This study aimed to investigate that AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer (GC) progression via targeted regulation of IRS-1 transcription. The utilized databases such as PhosphositePlus, TRANSFAC, CHEA, GPS 5.0, and TCGA, along with experimental techniques including Western Blot, co-IP, in vitro kinase assay, construction lentiviral overexpression silencing vectors, immunoprecipitation, modified proteomics, immunofluorescence, ChIP-PCR, EdU Transwell scratch assay the...