A5100373897- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- Monoclonal and Polyclonal Antibodies Research
- Radiopharmaceutical Chemistry and Applications
- Photoacoustic and Ultrasonic Imaging
- Gold and Silver Nanoparticles Synthesis and Applications
- Medical Imaging Techniques and Applications
- RNA Interference and Gene Delivery
- Toxin Mechanisms and Immunotoxins
- Lung Cancer Treatments and Mutations
- Extracellular vesicles in disease
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Neuroblastoma Research and Treatments
- Cell Adhesion Molecules Research
- ATP Synthase and ATPases Research
- HER2/EGFR in Cancer Research
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Ubiquitin and proteasome pathways
- T-cell and B-cell Immunology
- Virus-based gene therapy research
- Immune cells in cancer
- S100 Proteins and Annexins
The University of Texas MD Anderson Cancer Center
2016-2025
National Center for Chronic and Noncommunicable Disease Control and Prevention
2023-2025
Louisiana State University Health Sciences Center Shreveport
2013-2025
Beijing University of Chinese Medicine
2015-2024
Guangzhou University of Chinese Medicine
2023-2024
North China University of Technology
2024
Beihua University
2011-2024
Third Hospital of Changsha
2024
Anhui Agricultural University
2024
Xiamen University
2014-2024
We synthesized and evaluated a novel class of chelator-free [64Cu]CuS nanoparticles (NPs) suitable both for PET imaging as photothermal coupling agents ablation. These NPs are simple to make, possess excellent stability, allow robust noninvasive micro-PET imaging. Furthermore, the CuS display strong absorption in near-infrared (NIR) region (peak at 930 nm); passive targeting prefers tumor site, mediated ablation U87 cells occurs upon exposure NIR light vitro vivo after either intratumoral or...
We report dual-functional hollow gold nanospheres (HAuNS, ∼40-nm diameter) capable of mediating both photothermal ablation cancer cells and drug release upon near-infrared (NIR) light irradiation. As high as 63% DOX by weight (∼1.7 μg DOX/μg Au) could be loaded to polyethylene glycol (PEG)-coated HAuNS since was coated the outer inner surfaces HAuNS. Irradiation with NIR laser induced conversion, which triggered rapid from DOX-loaded The also pH-dependent, more released in aqueous solution...
Photoacoustic tomography (PAT) is an emerging molecular imaging modality. Here, we demonstrate use of semiconductor copper sulfide nanoparticles (CuS NPs) for PAT with Nd:YAG laser at a wavelength 1064 nm. CuS NPs allowed visualization mouse brain after intracranial injection, rat lymph nodes 12 mm below the skin interstitial and NP-containing agarose gel embedded in chicken breast muscle depth ~5 cm. This approach has great potential cancer.
Abstract Laser-induced phototherapy is a new therapeutic use of electromagnetic radiation for cancer treatment. The targeted plasmonic gold nanoparticles can reduce the laser energy necessary selective tumor cell destruction. However, ability delivery currently used to cells limited. Here, we describe class molecular specific photothermal coupling agents based on hollow nanoshells (HAuNS; average diameter, ∼30 nm) covalently attached monoclonal antibody directed at epidermal growth factor...
Abstract Metformin, the most prescribed antidiabetic medicine, has shown other benefits such as anti-ageing and anticancer effects 1–4 . For clinical doses of metformin, AMP-activated protein kinase (AMPK) a major role in its mechanism action 4,5 ; however, direct molecular target metformin remains unknown. Here we show that clinically relevant concentrations inhibit lysosomal proton pump v-ATPase, which is central node for AMPK activation following glucose starvation 6 We synthesize...
Noninvasive molecular and functional imaging in vivo is promising for detecting monitoring various physiological conditions animals ultimately humans. To this end, we present a novel noninvasive technology, spectroscopic photoacoustic tomography (SPAT), which offers both strong optical absorption contrast high ultrasonic spatial resolution. Optical allows separation of signal contributions from multiple absorbers (e.g., oxyhemoglobin, deoxyhemoglobin, agent), thus enabling simultaneous...
We describe the synthesis, characterization, and use of hybrid nanoparticles with a superparamagnetic iron oxide (SPIO) core gold nanoshell. These multifunctional nanoparticles, designated SPIO-Au nanoshells, displayed characteristics significant absorbance in near-infrared (NIR) region electromagnetic spectrum. In addition, they exhibited high transverse relaxivity, r2 , large r2/r1 ratio therefore could be imaged by MRI to obtain T2-weighted images. Moreover, nanoshells showed efficient...
Abstract Purpose: To develop melanoma-targeted hollow gold nanospheres (HAuNS) and evaluate their potential utility for selective photothermal ablation in melanoma. Experimental Design: A new class of coupling agents based on HAuNS was synthesized. were stabilized with polyethylene glycol (PEG) coating attached α–melanocyte-stimulating hormone (MSH) analog, [Nle4,D-Phe7]α-MSH (NDP-MSH), which is a potent agonist melanocortin type-1 receptor overexpressed The intracellular uptake the...
Translation of nanoparticles (NPs) into clinical practice has been limited by toxic effects induced nonspecific accumulation NPs in healthy organs after systemic administration. The ideal should accumulate the target site, carry out their function, and then ultimately be eliminated from body. Here, we show a single-compartment, multifunctional ultrasmall copper sulfide nanodot (CuS ND) that is rapidly cleared These CuS NDs have hydrodynamic diameter <6 nm, can efficiently absorb...
Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation IFN production are implicated in lymphopenia autoimmune diseases; therefore, a mechanism controlling is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript (ILT7). Here, we discovered ILT7 ligand expressed by human cell lines identified it as bone marrow stromal antigen 2...
Abstract NF-κB transcription factor is a critical regulator of the expression genes involved in tumor formation and progression. Successful RNA interference (RNAi) therapeutics targeting challenged by small interfering (siRNA) delivery systems, which can render targeted vivo delivery, efficient endolysosomal escape, dynamic control over activation RNAi. Here, we report near-IR (NIR) light–inducible downregulation through folate receptor–targeted hollow gold nanospheres carrying siRNA...
Abstract Immunotherapy has only limited efficacy against pancreatic ductal adenocarcinoma (PDAC) due to the presence of an immunosuppressive tumor-associated stroma. Here, we demonstrate effective modulation that stroma by irreversible electroporation (IRE), a local ablation technique received regulatory approval in United States. IRE induces immunogenic cell death, activates dendritic cells, and alleviates stroma-induced immunosuppression without depleting tumor-restraining collagen. The...
Abstract Copper chalcogenides have been demonstrated to be a promising photothermal agent due their high conversion efficiency, synthetic simplicity, and low cost. However, the hydrophobic less biocompatible characteristics associated with processes hamper widely biological applications. An alternative strategy for improving hydrophilicity biocompatibility is coat copper chalcogenide nanomaterials silica shell. Herein, rational preparation design results in successful coating mesoporous...
Abstract Ulcerative colitis (UC) is a complicated and recurrent intestinal disease. Currently available drugs for UC treatment are scarce, therefore, novel therapeutic the urgently to be developed. Gingerenone A (GA) phenolic compound known its anti‐inflammatory effect, but effect on remains unknown. Here, it shown that GA protects mice against UC, which closely associated with inhibiting mucosal inflammation enhancing barrier integrity in vivo vitro. Of note, RNA sequencing analysis...
Advancements in nanotechnology have made it possible to create multifunctional nanostructures that can be used simultaneously image and treat cancers. For example, hollow gold nanospheres (HAuNS) been shown generate intense photoacoustic signals induce efficient photothermal ablation (PTA) therapy. In this study, we tomography, a hybrid imaging modality, assess the intravenous delivery of HAuNS targeted integrins are overexpressed both glioma angiogenic blood vessels mouse model glioma. Mice...