A5101449724- Glycosylation and Glycoproteins Research
- COVID-19 Clinical Research Studies
- Galectins and Cancer Biology
- SARS-CoV-2 and COVID-19 Research
- Ferroptosis and cancer prognosis
- Carbohydrate Chemistry and Synthesis
- RNA modifications and cancer
- Antibiotic Resistance in Bacteria
- Protein Kinase Regulation and GTPase Signaling
- Cancer Immunotherapy and Biomarkers
- Traditional Chinese Medicine Analysis
- Flavonoids in Medical Research
- Long-Term Effects of COVID-19
- Retinoids in leukemia and cellular processes
- Genomics, phytochemicals, and oxidative stress
- Monoclonal and Polyclonal Antibodies Research
- Metabolism, Diabetes, and Cancer
- Phytochemistry and Biological Activities
- RNA regulation and disease
- Infectious Encephalopathies and Encephalitis
- Glutathione Transferases and Polymorphisms
- Antibiotics Pharmacokinetics and Efficacy
- MicroRNA in disease regulation
- Medical Research and Treatments
- Antibiotic Use and Resistance
Bengbu Medical College
2024-2025
Fifth Affiliated Hospital of Sun Yat-sen University
2009-2024
Zhongnan Hospital of Wuhan University
2015-2024
Wuhan University
2015-2024
First Affiliated Hospital of Bengbu Medical College
2024
Sun Yat-sen University
2009-2024
University of Florida
2021-2024
China Pharmaceutical University
2023
Zhengzhou University
2020-2023
Nanjing University of Chinese Medicine
2023
Treating COVID-19 with Chloroquine A novel coronavirus disease 2019 (COVID-19) emerged around December in Wuhan, China and has spread rapidly worldwide (Lu et al., 2020).Until March 27, 2020, the Chinese health authorities had reported 82082 confirmed cases 3298 deaths 381443 20787 outside China.The World Health Organization (WHO) named virus SARS-CoV-2, which belongs to a distinct clade from human severe acute respiratory syndrome CoV (SARS-CoV) Middle East (MERS-CoV) (Zhu 2020).At present,...
Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro. In this study, we aimed assess efficacy and safety of chloroquine with different doses COVID-19. multicenter prospective observational enrolled patients older than 18 years old confirmed infection excluding critical cases from 12 hospitals Guangdong Hubei Provinces. Eligible received phosphate 500 mg, orally, once (half dose) or twice (full...
Exosomes, a key element of the central nervous system microenvironment, mediate intercellular communication via horizontally transferring bioactive molecules. Emerging evidence has implicated exosomes in regulation neurogenesis. Recently, we compared neurogenic potential released from primary mouse embryonic neural stem cells (NSCs) and astrocyte-reprogrammed NSCs, observed diverse those two exosome populations vitro . However, roles NSC-derived on NSC differentiation underlying mechanisms...
Oxidative stress plays an important role in the pathogenesis of acute lung injury (ALI). As a typical post-translational modification triggered by oxidative stress, protein S-glutathionylation (PSSG) is regulated redox signaling pathways and diverse roles conditions. In this study, we found that GSTP downregulation exacerbated LPS-induced human epithelial cells mice ALI models, confirming protective effect against both vitro vivo. Additionally, positive correlation was observed between total...
Extracellular vesicles (EVs) are membrane-contained shed from cells. EVs contain proteins, lipids, and nucleotides, all of which play important roles in intercellular communication. The release is known to increase during neuroinflammation. Glutaminase, a mitochondrial enzyme that converts glutamine glutamate, has been implicated the biogenesis EVs. We have previously demonstrated TNF-α promotes glutaminase expression neurons. However, functionality astrocytes neuroinflammation remain...
Abstract Background The outbreak of COVID-19 (caused by SARS-Cov-2) is very serious, and no effective antiviral treatment has yet been confirmed. adage “old drug, new trick” in this context may suggest the important therapeutic potential existing drugs. We found that lopinavir/ritonavir recommended fifth edition Treatment Plan China can only help to improve a minority throat-swab nucleic-acid results (3/15) hospitals. Our previous use chloroquine treat patients with infection showed an...
Colorectal cancer (CRC) is one of the main cause cancer-related deaths. It's reported that bone marrow mesenchymal stem cells (BMSCs) affects tumor development through secreting exosomes. This study aims to investigate function BMSCs-derived exosome miR-4461 in CRC. The results qRT-PCR showed expression DLD1, HCT116 and SW480 CRC tissues was lower than FHC normal tissues, respectively. And COPB2 mRNA negatively correlated with miR-4461. Western blot used detect protein expression....
Abstract Background Effective therapies are urgently needed for the SARS-CoV-2 pandemic. Chloroquine has been proved to have antiviral effect against coronavirus in vitro. In this study, we aimed assess efficacy and safety of chloroquine with different doses COVID-19. Method multicenter prospective observational enrolled patients older than 18 years old confirmed infection excluding critical cases from 12 hospitals Guangdong Hubei Provinces. Eligible received phosphate 500mg, orally, once...
To investigate the correlation between hemiplegic shoulder pain factors during acute and chronic stages of stroke recovery.A prospective longitudinal study.Seventy-six patients with shoulders.Hemiplegic clinical, physical, sonography results were recorded at admission both (before discharge) (6 months after discharge).During stage, correlated significantly motor function level range motion limitations. During level, limitations, spasticity abnormal sonographic findings. Higher incidence...
Background: Lung adenocarcinoma ranks as the second most widespread form of cancer globally, accompanied by a significant mortality rate.Several studies have shown that T cell exhaustion is associated with immunotherapy tumours.Consequently, it essential to comprehend possible impact on tumor microenvironment.The purpose this research was create TEX-based model would use single-cell RNA-seq (scRNA-seq) and bulk-RNA sequencing explore new possibilities for assessing prognosis...
Lung adenocarcinoma (LUAD) is a highly aggressive tumor with one of the highest morbidity and mortality rates in world. Nucleotide metabolic processes are critical for cancer development, progression, alteration microenvironment. However, effect nucleotide metabolism on LUAD remains to be thoroughly investigated. Transcriptomic clinical data were downloaded organized from TCGA GEO databases. Genes related Msigdb database. associated prognosis identified using univariate COX analysis,...
Atherosclerosis (AS) is a progressive disease that contributes to cardiovascular and shows complex etiology, including genetic environmental factors. To understand systemic metabolic changes identify potential biomarkers correlated with the occurrence perpetuation of diet-induced AS, we applied 1H NMR-based metabolomics detect time-related profiles plasma, urine, liver extracts from male hamsters fed high fat cholesterol (HFHC) diet. Conventional biochemical assays histopathological...
The biological significance of phosphatidylcholine‐specific phospholipase C (PC‐PLC) in hepatocarcinogenesis and the proliferation differentiation rat liver cancer cells was investigated. Ca 2+ ‐dependent activities PC‐PLC gradually increased during N‐nitrosodiethylamine (DEN)‐induced peaked at weeks 18–20 when tumour formed. There a close relationship between cellular DNA content, membranous γ‐glutamyltranspeptidase (γ‐GT), tyrosine protein kinase. In contrast, ‐independent decreased...
The effects of transfection the metastasis suppressor gene nm23-H1 and cell-cycle related tumor-suppressor p16 on activity N-acetylglucosaminyltransferase V (GnT-V) their relations to cancer metastatic potential were investigated. After into 7721 human hepatocarcinoma cells A549 lung cells, activities GnT-V decreased by 28%–42% in cells. In contrast, when was transfected these two cell lines, decrease only observed This probably be due obvious expression parental deletion mRNA...
: There is an association between LUAD and TB, TB increases the risk of lung adenocarcinogenesis. However, role in development adenocarcinoma has not been clarified.
This study aims to investigate the correlation between premature coronary heart disease (pCHD) and both serum homocysteine (Hcy) hypersensitive C-reactive protein (hs-CRP).A total of 170 patients with pCHD were enrolled in this from June 2014 April 2016 (including 52 stable angina pectoris [SAP], 70 unstable [UAP], 48 acute myocardial infarction [AMI]), together 105 healthy controls (CON) selected at same period, observe changes Hcy hs-CRP CHD those different types CHD.The levels group...
Genipin (GP), the reactive metabolite of geniposide (GE), is responsible for GE-induced hepatotoxicity. As a potential detoxification pathway, inactivation GP by glutathione S-transferases (GSTs) has not yet been characterized. In this study, thiol-GSH conjugates GP, M532-1 and M532-2 were first identified catalytic activities GSTs investigated both in vitro vivo. GSTA1-1 GSTA4-4 showed high activity formation conjugates, whereas specifically catalyzed vitro. The active GST isoforms protect...
This study evaluated the subacute toxicity and toxicokinetics of a potential anti-cancer drug candidate, pterostilbene, in rats. Animals were orally administered at two repeated doses 200 500 mg/kg for 28 days. No mortality was observed during days continuous administration pterostilbene. Body weight food consumption each group increased steadily, while no significant difference found. Liver female, but not male with mild cytoplasmic vacuoles histopathological study. Toxicokinetics assessed...
To improve the treatment of infectious diseases in patients with crush syndrome, we analyzed results bacteriological examinations, including antimicrobial susceptibility patterns, samples taken from syndrome admitted to West China Hospital, Sichuan University, after Wenchuan earthquake. A total 210 non-replicate clinical isolates were recovered 42 66 earthquake victims syndrome. Their mean age was 26.9 ± 15.7 y and 40 them male. The length hospital stay 14.0 days. Wound, blood, sputa, urine...