A5027741016- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Neuroendocrine regulation and behavior
- Pluripotent Stem Cells Research
- Immune cells in cancer
- Hormonal Regulation and Hypertension
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neural Engineering
- Extracellular vesicles in disease
- Treatment of Major Depression
- Receptor Mechanisms and Signaling
- Hypothalamic control of reproductive hormones
- Retinoids in leukemia and cellular processes
- Epigenetics and DNA Methylation
- Biochemical and Molecular Research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Adrenal Hormones and Disorders
- Cardiac Imaging and Diagnostics
- Metabolism and Genetic Disorders
- Marine Sponges and Natural Products
- Mast cells and histamine
Tongji University
2015-2025
Tongji Hospital
2022-2025
Second Affiliated Hospital of Nanchang University
2024
Nanchang University
2024
Shanghai Tenth People's Hospital
2015-2022
Netherlands Institute for Neuroscience
2010-2018
Royal Netherlands Academy of Arts and Sciences
2012-2018
University of Science and Technology of China
2010-2017
Chinese Academy of Sciences
2010-2012
Cerebral ischemia induces a robust neuroinflammatory response that is largely mediated by the activation of CNS resident microglia. Activated microglia produce pro-inflammatory molecules to cause neuronal damage. Identifying regulators microglial bears great potential in discovering promising candidates for neuroprotection post cerebral ischemia. Previous studies demonstrate abnormal elevation glutaminase 1 (GLS1) chronic disorders including Alzheimer's disease and HIV-associated...
Exosomes, a key element of the central nervous system microenvironment, mediate intercellular communication via horizontally transferring bioactive molecules. Emerging evidence has implicated exosomes in regulation neurogenesis. Recently, we compared neurogenic potential released from primary mouse embryonic neural stem cells (NSCs) and astrocyte-reprogrammed NSCs, observed diverse those two exosome populations vitro . However, roles NSC-derived on NSC differentiation underlying mechanisms...
Glutaminase 1 (GLS1) has recently been reported to be expressed in microglia and plays a crucial role neuroinflamation. Significantly increased level of GLS1 mRNA expression together with neuroinflammation pathway were observed postmortem prefrontal cortex from depressed patients. To find out the function microglial depression neuroinflammation, we generated transgenic mice (GLS1 cKO), postnatally losing microglia, detect changes lipopolysaccharide (LPS)-induced model. LPS-induced...
The prefrontal cortex shows structural and functional alterations in mood disorders. Retinoid signaling, brain-derived neurotrophic factor (BDNF), its receptor TrkB are reported to be involved depression. Here, we found that mRNA levels of key elements retinoid signaling were significantly reduced the postmortem dorsolateral cortex/anterior cingulate (ACC) from elderly depressed patients who did not die suicide. Decreased BDNF isoforms also found. Similar observed rats subjected chronic...
Decreased function of the anterior cingulate cortex (ACC) is crucially involved in pathogenesis depression. A key role nitric oxide (NO) has also been proposed. We aimed to determine NO content cerebrospinal fluid (CSF) and expression synthase (NOS) isoforms, that is, NOS1, NOS2, NOS3 ACC In depressive patients, CSF-NOx levels (the metabolites nitrite nitrate) were significantly decreased (P = 0.007), indicating a more general decrease production this disorder. This agreed with trend toward...
Abstract Early-life stress (ELS) leads to stress-related psychopathology in adulthood. Although dysfunction of corticotropin-releasing hormone (CRH) signaling the bed nucleus stria terminalis (BNST) mediates chronic stress-induced maladaptive affective behaviors that are historically associated with mood disorders such as anxiety and depression, it remains unknown whether ELS affects CRH function adult BNST. Here we applied a well-established paradigm (24 h maternal separation (MS) at...
Clinical reports have highlighted a role for retinoids in the etiology of mood disorders. Although we had shown that recruitment nuclear receptor retinoic acid receptor-α (RAR-α) to corticotropin-releasing hormone (CRH) promoter is implicated activation hypothalamus–pituitary–adrenal (HPA) axis, further insight into how modulate HPA axis activity lacking. Here show all-trans (RA)-induced involves impairments glucocorticoid (GR) negative feedback. RA was applied rats chronically through...
Degeneration of midbrain dopaminergic (DA) neurons is a key pathological event Parkinson's disease (PD). Limited adult neurogenesis has led to novel therapeutic strategies such as transplantation precursors (DPs). However, this strategy currently restrained by lack cell source, the tendency for DPs become glial-restricted state, and tumor formation after transplantation. Here, we demonstrate direct conversion mouse fibroblasts into induced (iDPs) ectopic expression Brn2, Sox2 Foxa2. Besides...
Clinical studies have highlighted an association between retinoid treatment and depressive symptoms. As we had shown before that chronic application of all-trans retinoic acid (RA) potently activated the hypothalamus-pituitary-adrenal (HPA) stress axis, here questioned whether RA also induced changes in adult hippocampal neurogenesis, a form structural plasticity sensitive to implicated aspects depression function. was applied intracerebroventricularly (i.c.v.) rats for 19 days after which...
Glia alterations in the anterior cingulate cortex (ACC) and dorsolateral prefrontal (DLPFC) have been postulated to play an important role pathophysiology of psychiatric disorders. Astroglia is most abundant type glial cells central nervous system. The expression levels astrocyte markers (glial fibrillary acidic protein (GFAP), synemin-α, synemin-β, vimentin, nestin) isolated gray matter from postmortem ACC DLPFC were determined investigate possible involvement astrocytes depression. Donors...
An abnormal glutamate signaling pathway has been proposed in the mechanisms of autism spectrum disorder (ASD). However, less is known about involvement alterations glutaminase 1 (GLS1) pathophysiology ASD. We show that transcript level GLS1 significantly decreased postmortem frontal cortex and peripheral blood ASD subjects. Mice lacking Gls1 CamKIIα-positive neurons display a series ASD-like behaviors, synaptic excitatory inhibitory (E/I) imbalance, higher spine density, receptor expression...
Anxiety is highly prevalent among cancer patients, significantly impacting their prognosis. Current therapies typically lack anxiolytic properties and may even exacerbate anxiety. Here, a gasotransmitter-nanodonors (GND) system presented that exerts dual anti-tumor effects via "tumor-brain axis" strategy. The GND, synthesized by co-embedding Fe2⁺ S2⁻ ions along with glucose oxidase (GOx) within bovine serum albumin (BSA) nanoparticles (FSG@AB), enables the controlled release of...
Activation of the hypothalamic-pituitary-adrenal axis is considered to be one key physiological responses stress and, interestingly, shows a marked sex difference. Oestradiol plays an important role in this The present study investigated systemic and intrahypothalamic oestradiol response physical restraint female rats. We used jugular catheterisation microdialysis simultaneously measure plasma local concentrations paraventricular nucleus (PVN) hypothalamus. also assessed...
Growing evidence indicates that microglia activation and a neuroinflammatory trigger contribute to dopaminergic cell loss in Parkinson's disease (PD). Furthermore, increased density of histaminergic fibers enhanced histamine levels have been observed the substantia nigra PD-postmortem brains. Histamine-induced microglial is mediated by histamine-4 receptor (H4R). In current study, gene set enrichment pathway analyses PD basal ganglia RNA-sequencing dataset revealed upregulation H4R was top...
Cell replacement therapy has been envisioned as a promising treatment for neurodegenerative diseases. Due to the ethical concerns of ESCs-derived neural progenitor cells (NPCs) and tumorigenic potential iPSCs, reprogramming somatic directly into multipotent NPCs emerged preferred approach cell transplantation.Mouse astrocytes were reprogrammed by overexpression transcription factors (TFs) Foxg1, Sox2, Brn2. The generation subtypes neurons was directed force expression cell-type specific TFs...
The pathogenesis of Alzheimer's disease (AD) remains unknown till today, hindering the research and development AD therapeutics diagnostics. Circulating extracellular vesicles (EVs) can be utilized as a new window to spy upon pathogenesis. Altered microRNA profiles were noted in both cerebrospinal fluid (CSF)- blood-isolated EVs patients, implying outstanding potential circulating EV-containing miRNAs (CEmiRs) serve important regulators Although several CEmiRs found play part AD, association...
Abstract Altered levels of steroids have been reported in the brain, cerebral spinal fluid and plasma patients with mood disorders. Neuroimaging studies both functional structural alterations disorders, for instance anterior cingulate cortex (ACC) dorsolateral prefrontal (DLPFC). In order to determine whether endogenous production is altered ACC DLPFC major depressive disorder (MDD) or bipolar (BPD), quantitative real‐time PCR was performed detect mRNA expression level key enzymes steroid...
To address which mitochondria-related nuclear differentially expressed genes (DEGs) and related pathways are altered during human oocyte maturation, single-cell analysis was performed in three states: vivo matured (M-IVO), vitro (M-IVT), failed to mature (IM-IVT). There were 691 DEGs 16 the comparison of M-IVT vs. IM-IVT oocytes, 2281 160 M-IVO respectively. The GO KEGG analyses showed that most them involved such as oxidative phosphorylation, pyruvate metabolism, peroxisome, amino acid...