A5010477227- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Ion Channels and Receptors
- Parkinson's Disease Mechanisms and Treatments
- Cellular Mechanics and Interactions
- Autophagy in Disease and Therapy
- Olfactory and Sensory Function Studies
- Genetics, Aging, and Longevity in Model Organisms
- Genetic Neurodegenerative Diseases
- Air Quality and Health Impacts
- Immune Cell Function and Interaction
- Receptor Mechanisms and Signaling
- Advanced battery technologies research
- Inflammation biomarkers and pathways
- Protein Kinase Regulation and GTPase Signaling
- IL-33, ST2, and ILC Pathways
- Nerve injury and regeneration
- T-cell and B-cell Immunology
- Mast cells and histamine
- Chemotherapy-induced organ toxicity mitigation
- Wnt/β-catenin signaling in development and cancer
- Tryptophan and brain disorders
- Dialysis and Renal Disease Management
- Plant Stress Responses and Tolerance
- Acute Kidney Injury Research
Zhejiang University
2023-2025
First Affiliated Hospital Zhejiang University
2021-2024
Dalian Medical University
2018-2023
Background: Cisplatin is a widely used anti-tumor agent but its use frequently limited by nephrotoxicity.Transient receptor potential melastatin 2 (TRPM2) non-selective cation channel which generally viewed as sensor of oxidative stress, and increasing evidence supports link with autophagy, critical process for organelle homeostasis.Methods: Cisplatin-induced cell injury mitochondrial damage were both assessed in WT Trpm2-knockout mice primary cells.RNA sequencing, immunofluorescence...
Abstract Regulating cardiolipin to maintain mitochondrial homeostasis is a promising strategy for addressing Parkinson's disease (PD). Through comprehensive screening and validation process involving multiple models, ginsenoside Rg3 (Rg3) as compound capable of enhancing levels identified. This augmentation in fosters by bolstering unfolded protein response, promoting mitophagy, oxidative phosphorylation. Consequently, this cascade enhances the survival tyrosine hydroxylase positive (TH + )...
Peak1-related, kinase-activating pseudokinase 1 (PRAG1), a member of the pseudopodium-enriched atypical kinase (PEAK) family pseudokinases, has been reported to play role in regulating cell morphology. However, molecular mechanism for this function remains elusive. In study, we demonstrate that PRAG1 forms dynamic condensates cells mediated by its αN and αJ helices. Importantly, found functioned mediating contraction, while condensate-formation-deficient mutants lost function. Remarkably,...
Growing evidence indicates that microglia activation and a neuroinflammatory trigger contribute to dopaminergic cell loss in Parkinson's disease (PD). Furthermore, increased density of histaminergic fibers enhanced histamine levels have been observed the substantia nigra PD-postmortem brains. Histamine-induced microglial is mediated by histamine-4 receptor (H4R). In current study, gene set enrichment pathway analyses PD basal ganglia RNA-sequencing dataset revealed upregulation H4R was top...
Cerebral ischemia-reperfusion (I-R) transiently increased autophagy by producing excessively reactive oxygen species (ROS); on the other hand, activated would remove ROS-damaged mitochondria and proteins, which led to cell survival. However, regulation mechanism of activity during cerebral I-R is still unclear. In this study, we found that deficiency TRPM2 channel a ROS sensor significantly decreased I-R-induced neuronal damage. both in vitro vivo. More importantly, neurological deficit...
Different dopaminergic (DA) neuronal subgroups exhibit distinct vulnerability to stress, while the underlying mechanisms are elusive. Here we report that transient receptor potential melastatin 2 (TRPM2) channel is preferentially expressed in vulnerable DA subgroups, which correlates positively with aging Parkinson's Disease (PD) patients. Overexpression of human TRPM2 neurons C. elegans resulted selective death ADE but not CEP aged worms. Mechanistically, activation mediates...
Pathological dry skin is a disturbing and intractable healthcare burden, characterized by epithelial hyperplasia severe itch. Atopic dermatitis (AD) psoriasis models with complications of have been studied using single-cell RNA sequencing (scRNA-seq). However, scRNA-seq analysis the mouse model (acetone/ether/water (AEW)-treated model) still lacking. Here, we used in situ hybridization to identify novel proliferative basal cell (PBC) state that exclusively expresses transcription factor...
Abstract Background: PM 2.5 , the main particulate air pollutant, poses serious hazard to human health. Alzheimer's disease (AD) is a major neurodegenerative characterized by amyloid plaques and neurofibrillary tangles. Recent studies reported that could promote AD-like pathologies in brain. However, mechanism of -induced changes still unclear more investigations are needed for further understanding. Methods: In this study, we established experimental model long-term exposure with young/old...