A5069673631- Ion Channels and Receptors
- Calcium signaling and nucleotide metabolism
- Plant Stress Responses and Tolerance
- Biochemical effects in animals
- Endoplasmic Reticulum Stress and Disease
- Immune Cell Function and Interaction
- Neurobiology and Insect Physiology Research
- Phytochemicals and Antioxidant Activities
- COVID-19 Clinical Research Studies
- Plant and Biological Electrophysiology Studies
- Mitochondrial Function and Pathology
- Genetics, Aging, and Longevity in Model Organisms
- Ion channel regulation and function
- Biochemical Analysis and Sensing Techniques
Zhejiang University
2023-2025
First Affiliated Hospital Zhejiang University
2023
Xinxiang Medical University
2023
Hepatic ischemia-reperfusion (IR) injury is a serious clinical problem that complicates liver resection and transplantation. Despite recent advances in understanding of the pathophysiology hepatic IR injury, effective interventions therapeutics are still lacking. Here, we examined role transient receptor potential melastatin 2 (TRPM2), Ca2+-permeable, non-selective cation channel, mediating injury. Our data showed TRPM2 deficiency attenuated IR-induced dysfunction, inflammation, cell death...
Background: HCC is one of the most common causes cancer-related deaths. Transient receptor potential melastatin 2 (TRPM2), a Ca 2+ -permeable cation channel, was reported to be involved in carcinogenesis and tumor growth recently. However, whether TRPM2 pathogenesis progression remains unclear. Herein, we systematically elucidated functional role cell cycle regulation proliferation. Approach Results: We determine expression strongly upregulated tissues patients associated with negative...
Abstract Sepsis is characterized by a systemic host response to infection. Monocytes, as major mediators of acute infection, are implicated in complications among critically ill patients. Identifying key monocyte subsets and their activation states essential for diagnosis delineating new therapeutic targets sepsis. Here, single cell transcriptome sequencing mass cytometry used assess alterations the composition function peripheral monocytes patients with sepsis, CD38 high circulation...
Different dopaminergic (DA) neuronal subgroups exhibit distinct vulnerability to stress, while the underlying mechanisms are elusive. Here we report that transient receptor potential melastatin 2 (TRPM2) channel is preferentially expressed in vulnerable DA subgroups, which correlates positively with aging Parkinson's Disease (PD) patients. Overexpression of human TRPM2 neurons C. elegans resulted selective death ADE but not CEP aged worms. Mechanistically, activation mediates...
Ion channel activation upon ligand gating triggers a myriad of biological events and, therefore, evolution mechanism is fundamental importance. TRPM2, typical ancient ion channel, activated by adenosine diphosphate ribose (ADPR) and calcium its has evolved from simple mode in invertebrates to more complex one vertebrates, but the evolutionary process still unknown. Molecular analysis TRPM2s than 280 different animal species revealed that, C-terminal NUDT9-H domain an enzyme binding site for...
Abstract Ion channel activation upon ligand gating triggers a myriad of biological events and, therefore, evolution mechanism is fundamental importance. TRPM2, typical ancient ion channel, activated by adenosine diphosphate ribose (ADPR) and calcium its has evolved from simple mode in invertebrates to more complex one vertebrates, but the evolutionary process still unknown. Molecular analysis TRPM2s than 280 different animal species revealed that, C-terminal NUDT9-H domain an enzyme binding...
To establish a cell line stably expressing the TRPM2 channel for screening inhibitors based on PiggyBac transposition system.