A5041505370- Orthopaedic implants and arthroplasty
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Nerve injury and regeneration
- Autophagy in Disease and Therapy
- Anesthesia and Neurotoxicity Research
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Genetic factors in colorectal cancer
- Peptidase Inhibition and Analysis
- Ion Channels and Receptors
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Hip disorders and treatments
- Medical Imaging and Analysis
- Click Chemistry and Applications
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Antenna Design and Analysis
- Energy Harvesting in Wireless Networks
- Polymer Surface Interaction Studies
- Management of metastatic bone disease
- Chemical Synthesis and Analysis
Peking University People's Hospital
2020-2025
Peking University
2020-2025
Tsinghua University
2020-2025
Tsinghua–Berkeley Shenzhen Institute
2022-2025
Huazhong University of Science and Technology
2025
Tongji Hospital
2025
Chongqing University of Technology
2023-2025
China Pharmaceutical University
2025
Guangzhou Sport University
2025
Zhejiang University
2002-2024
Amino groups were covalently introduced onto a polycaprolactone (PCL) surface by the reaction between 1,6-hexanediamine and ester of PCL. The occurrence aminolysis introduction free NH2 verified qualitatively fluorescence spectroscopy, where rhodamine B isothiocyanate was employed to label groups, quantitatively absorbance ninhydrin used react with generate blue product. Due presence deep pores on PCL membrane, could penetrate as 50 μm yield density high 2 × 10-7 mol/cm2. By use active...
A novel technique to introduce free amino groups onto polyester scaffolds via aminolyzing the ester with diamine has been developed recently. Positively charged chitosan was then deposited aminolyzed poly(l-lactic acid) (PLLA) membrane surface in a layer-by-layer assembly manner using poly(styrene sulfonate, sodium salt) (PSS) as negatively polyelectrolyte. The deposition process of PSS and monitored by UV-vis absorbance spectroscopy, energy transfer fluorescence advancing contact angle...
Severe spinal cord injury (SCI) can cause neurological dysfunction and paralysis. However, the early dynamic changes of neurons their surrounding environment after SCI are poorly understood. Although methylprednisolone (MP) is currently standard therapeutic agent for treating SCI, its efficacy remains controversial. The purpose this project was to investigate MP's on axonal damage, blood flow, calcium influx into axons in a mouse model. YFP H-line Thy1-GCaMP transgenic mice were used study....
Background Accurate preoperative planning is essential for successful total hip arthroplasty (THA). However, the requirements of time, manpower, and complex workflow accurate have limited its application. This study aims to develop a comprehensive artificial intelligent system THA (AIHIP) validate accuracy in clinical performance. Methods Over 1.2 million CT images from 3,000 patients were included an intelligence (AIHIP). Deep learning algorithms developed facilitate automatic image...
Early diagnosis of breast cancer has always been a difficult clinical challenge. We developed deep-learning model EDL-BC to discriminate early with ultrasound (US) benign findings. This study aimed investigate how the could help radiologists improve detection rate while reducing misdiagnosis.In this retrospective, multicentre cohort study, we an ensemble deep learning called based on convolutional neural networks. The was trained and internally validated B-mode color Doppler US image 7955...
Rhubarb is the peeled and dried roots of Rheum palmatum L. tanguticum Maxim. ex Balf. or officinale Baill. Free total rhubarb anthraquinones (FTRAs) were isolated extracted from rhubarb. Previous studies have revealed that early administration FTRAs protects intestinal mucosal barrier in rats with severe acute pancreatitis (SAP), mechanism which not yet clear. However, we observed an enhanced expression pyroptotic factors treated SAP, may be related to protection by FTRAs. The main objective...
Horseradish peroxidase (HRP) was encapsulated in preformed polyelectrolyte multilayer (PEM) microcapsules by spontaneous deposition with remarkably improved stability and catalytic activity.
Aims To investigate the benefits of denosumab in combination with nerve-sparing surgery for treatment sacral giant cell tumours (GCTs). Methods This is a retrospective cohort study patients GCT who presented between January 2011 and July 2017. Intralesional curettage was performed treated from 2015 to 2017 also received therapy. The were divided into three groups: Cohort 1: control group (n = 36); 2: adjuvant 9); 3: neo- adjuvant-denosumab 17). Results There 68 within period. Six lost...
Accurate preoperative planning for total knee arthroplasty (TKA) is crucial. Computed tomography (CT)-based offers more comprehensive information and can also be used to design patient-specific instrumentation (PSI), but it requires well-reconstructed segmented images, the process complex time-consuming. This study aimed develop an artificial intelligence (AI) PSI system TKA validate its time savings accuracy in clinical applications.The 3D-UNet modified HRNet neural network structures were...
Background Owing to the long penetration depth of gamma (γ)-rays, individuals working in ionizing radiation environments are chronically exposed low-dose γ-radiation, resulting cognitive changes. Dose rate significantly affects radiation-induced biological effects; however, its role chronic γ-irradiation-induced impairment remains unclear. We aimed investigate whether γ-irradiation at low-dose-rate (LDR) could induce and compare alteration caused by LDR high-dose-rate (HDR). Methods The rats...
Cerebral dopamine neurotrophic factor (CDNF), previously known as the conserved factor, belongs to evolutionarily CDNF/mesencephalic astrocyte-derived MANF family of factors that demonstrate activities in dopaminergic neurons. The function CDNF during brain ischemia is still not known. identified an endoplasmic reticulum (ER) stress protein; however, role ER remains be fully elucidated. Here, we test neuroprotective effect on middle cerebral artery occlusion (MCAO) rats and neurons...
Abstract Purposes Radiotherapy can induce tumor cell autophagy, which might impair the antitumoral effect. This study aims to investigate effect of autophagy inhibition on targeted radionuclide therapy (TRT) efficacy 131 I-FAP-2286 in pancreatic cancer. Methods Human cancer PANC-1 cells were exposed radiotherapy alone or with inhibitor 3-MA. The level and proliferative activity analyzed. xenograft-bearing nude mice established by co-injection cancer-associated fibroblasts (CAFs), then...
Background The high prevalence of low back pain has led to an increasing demand for the analysis lumbar magnetic resonance (MR) images. This study aimed develop and evaluate a deep-learning-assisted automated system diagnosing grading intervertebral disc degeneration based on T2-weighted sagittal axial MR Methods included total 472 patients who underwent scans between January 2021 November 2023, with 420 in internal dataset 52 external dataset. images were evaluated labeled by experts...
Abstract Hemagglutinin (HA) is an important glycoprotein on the surface of influenza virus, which involved in virus attachment to host cells through viral membrane and fusion with cell form cells. H3N2 inhibitors can bind hydrophobic cavities at HA pre‐polymer interface, preventing its conformational rearrangement ultimately inhibiting fusion. In this study, 46 imidazole [1, 2‐α] pyrimidine derivatives were analyzed using two different analytical methods (CoMFA CoMSIA) a reliable 3D‐QSAR...
<title>Abstract</title> <bold>Background: </bold>Intervertebral disc degeneration (IDD) is a chronic, noninflammatory, degenerative process that occurs in the lumbar spine and surrounding soft tissues. Although dyslipidemia has been proven to be related changes spine, its relationship with IDD severity of not fully explored elucidated. This study employed deep learning improve prediction accuracy suggest new preventive therapeutic strategies for clinical application. <bold>Methods:</bold> We...
Abstract Background This study aimed to investigate the role of MIR17HG in non-small cell lung cancer (NSCLC). Methods Differential expression NSCLC was first detected by exploring TCGA dataset. Expression levels miR-142-3p both and non-tumor tissues were determined qPCR. The effects overexpressing on methylation miR-142 assessed MSP. MIR17HG, Bach-1 invasion migration cells Trasnwell or assay. Results Analysis dataset revealed slightly downregulated NSCLC. downregulation further confirmed...
Scaffold materials, neurotrophic factors, and seed cells are three elements of neural tissue engineering. As well-known self-assembling peptide-based hydrogels, RADA16-I modified peptides attractive matrices for In addition to its neuroprotective effects, cerebral dopamine factor (CDNF) has been reported promote the proliferation, migration, differentiation stem (NSCs). However, role combined with CDNF on NSCs remains unknown. First, effect hydrogel proliferation cultured was investigated....
Psoriasis is a chronic disease with elusive pathogenesis linked to genetic, and immune factors. Studies have shown most patients experienced high levels of oxidative stress, which can lead inflammation or damage. Withaferin A natural product multiple pharmacological activities, including anti-tumor anti-inflammatory effects. We investigated the effects WA in treating Imiquimod (IMQ)-induced psoriasis mice. The epidermal pathology mice was significantly improved after treatment. inhibited by...
Objective To investigate whether physical literacy mediates the relationship between grit and well-being among college students with obesity. Methods A total of 385 obesity were recruited. Participants completed validated questionnaires measuring grit, literacy, well-being. Mediation analyses performed to estimate indirect effects generate bias-corrected 95% confidence intervals (CI). Results Grit was positively associated Physical partially mediated well-being, effect accounting for 26.32%...