A5007502535- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- interferon and immune responses
- Epigenetics and DNA Methylation
- Lung Cancer Research Studies
- Cancer, Hypoxia, and Metabolism
- Glutathione Transferases and Polymorphisms
- Biliary and Gastrointestinal Fistulas
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Nanowire Synthesis and Applications
- Hepatitis Viruses Studies and Epidemiology
- DNA Repair Mechanisms
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- CAR-T cell therapy research
- Congenital Anomalies and Fetal Surgery
- Ion Channels and Receptors
- Plant Stress Responses and Tolerance
- Peptidase Inhibition and Analysis
- Ocular Diseases and Behçet’s Syndrome
Zhejiang University
2019-2025
First Affiliated Hospital Zhejiang University
2019-2025
Blood Center of Zhejiang Province
2019-2025
Zhejiang Lab
2024
Shanghai Clinical Research Center
2020-2024
Zhejiang Cancer Hospital
2023-2024
Abstract PD-1 (CD279)–PD-L1 (CD274) inhibitory signaling is critical for cancer immune evasion, and thus has become one of the major targets in anticancer immunotherapy. There are several studies that demonstrate potent effects posttranslational modifications CD274 on inactivation suppression, such as ubiquitination, phosphorylation, glycosylation, palmitoylation. However, regulatory mechanisms deubiquitination still largely unclear. Here, we identified ubiquitin-specific protease 22 (USP22)...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a kind of tumor lacking nutrients due to its poor vascularity and desmoplasia. Recent studies have shown that cancer cells might achieve growth advantage through epitranscriptome reprogramming. However, the role m 5 C in PDAC was not fully understood. We found Aly/REF export factor (ALYREF), reader modification, overexpressed PDAC, associated with bad prognosis. In addition, ALYREF expression negatively related CD8 + T infiltration clinical...
Characterized by progressive degeneration of retinal ganglion cells (RGCs) and vision loss, glaucoma is the primary cause irreversible blindness, incurable affecting over 78 million patients. However, pathogenic mechanisms leading to glaucoma-induced RGC loss are incompletely understood. Unexpectedly, we found that cGAS-STING (2'3'-cyclic GMP-AMP-stimulator interferon genes) signaling, which surveils displaced double-stranded DNA (dsDNA) in cytosol initiates innate immune responses, was...
Tumor heterogeneity plays a pivotal role in tumor progression and resistance to clinical treatment. Single-cell RNA sequencing (scRNA-seq) enables us explore within cell population identify rare types, thereby improving our design of targeted therapeutic strategies. Here, we use pan-cancer pan-tissue single-cell transcriptional landscape reveal heterogeneous expression patterns malignant cells, precancerous as well cancer-associated stromal endothelial cells. We introduce deep learning...
Background Solid tumors pose unique roadblocks to treatment with chimeric antigen receptor (CAR) T cells, including limited T-cell persistence, inefficient tumor infiltration, and an immunosuppressive microenvironment. To date, attempts overcome these have been unsatisfactory. Herein, we reported a strategy of combining Runx3 (encoding RUNX family transcription factor 3)-overexpression ex vivo protein kinase B (AKT) inhibition generate CAR-T cells both central memory tissue-resident...
Abstract Nanocarriers are essential for targeted and enhanced drug delivery. However, the use of toxic solvent complex chemical functionalization have seriously limited their clinical translation. Here, a one‐step strategy is developed to direct self‐assembly biocompatible core‐shell nanocapsules with tunable surface functionality by microfluidics. Upon rapid mixing exchange ethanol water in microfluidic device, drug, oil, polymer, polymer‐PEG‐function co‐precipitate self‐assemble into...
Background: HCC is one of the most common causes cancer-related deaths. Transient receptor potential melastatin 2 (TRPM2), a Ca 2+ -permeable cation channel, was reported to be involved in carcinogenesis and tumor growth recently. However, whether TRPM2 pathogenesis progression remains unclear. Herein, we systematically elucidated functional role cell cycle regulation proliferation. Approach Results: We determine expression strongly upregulated tissues patients associated with negative...
Chronic infections with hepatitis E virus (HEV), especially those of genotype 3 (G3), frequently lead to liver fibrosis and cirrhosis in patients. However, the causation mechanism triggered by chronic HEV infection remain poorly understood. Here, we found that viral multiple-domain replicase (ORF1) undergoes unique ubiquitin–proteasomal processing leading formation H EV- D erived S MAD A ctivator (HDSA), a polypeptide lacking putative helicase RNA polymerase domains. The HDSA is stable,...
Objective: This study evaluated the effect of neoadjuvant therapy (NAT) and prognostic significance carcinoembryonic antigen (CEA) levels in patients with non-elevated serum carbohydrate (CA) 19-9 levels. Summary Background Data: The impact NAT followed by surgical resection on oncologic outcomes localized pancreatic ductal adenocarcinoma (PDAC) remains unclear. Methods: retrospective propensity-score matched (PSM) included primary validation cohorts from four centers. Propensity scores were...
Abstract Chemotherapy is an effective option for cancer treatment. However, its clinical application often limited by the severe side effects of chemical drugs. To overcome these limitations, a novel drug‐loaded phase‐change nanocapsule system developed. These nanocapsules are assembled via one‐step electrostatic self‐assembly through guided interfacial engineering. The phase change material core demonstrate great photothermal‐controlled drug release performance and exhibit excellent...
RAD51 is related to the bacterial RecA protein and best known for its role in homologous recombination-mediated repair of DNA damage. Here, we report an unexpected function maintenance methylation genomic DNA, a that separable from recombination. First, it acts as inhibitor E3 ubiquitin ligase UHRF1. Deficiency causes excessive ubiquitination degradation methyltransferase DNMT1, leading loss global methylation. Second, helps UHRF1 monoubiquitinate histone H3 generate DNMT1 recruiting signal....
Abstract Mechanical control is fundamental for cellular localization within a tissue, including tumor-associated macrophages (TAMs). While the innate immune sensing pathways cGAS-STING and RLR-MAVS impact pathogenesis therapeutics of malignant diseases, their effects on cell residency motility remain incompletely understood. Here, we uncovered that TBK1 kinase, activated by or signaling in macrophages, directly phosphorylates mobilizes Zyxin, key regulator actin dynamics. Under pathological...
e15764 Background: The progression and metastasis of pancreatic ductal adenocarcinoma (PDAC) is highly dependent on the tumor microenvironment. Most tumor-associated macrophages (TAMs) are M2 phenotypic macrophages, which normally show anti-inflammatory functions in numerous disorders. We previously found that alternatively activated showed pro-inflammatory characteristics upon stimulation hepatoma cell-derived debris, but molecular mechanism was unclear. Methods: Macrophages were induced...
Probing relevant proteomic biomarkers may facilitate effective pancreatic adenocarcinoma (PDAC) diagnosis, treatment and prevention. Here, we developed a protein-based prognostic model for PDAC by using data from The Cancer Genome Atlas (TCGA).We obtained PDAC's clinical TCGA used various analytical tools to identify differentially expressed proteins between normal cancer tissues. We constructed our confirmed its accuracy receiver operating characteristic curve Kaplan-Meier survival...